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Iigp1 Gene Detail
Summary
  • Symbol
    Iigp1
  • Name
    interferon inducible GTPase 1
  • Synonyms
    2900074L10Rik, Irga6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926259
    NCBI Gene: 60440
  • Alliance
    gene page
  • Transcription Start Sites
    38 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:60509099-60525706 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 34.36 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926259
 protein coding gene Chr18:60506688-60525706 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024458
 protein coding gene Chr18:59969594-59979033 (+)
A/J MGP_AJ_G0024424
 protein coding gene Chr18:57413142-57425778 (+)
AKR/J MGP_AKRJ_G0024397
 protein coding gene Chr18:59201435-59204272 (+)
BALB/cJ MGP_BALBcJ_G0024426
 protein coding gene Chr18:57729477-57732313 (+)
C3H/HeJ MGP_C3HHeJ_G0024194
 protein coding gene Chr18:59426059-59428894 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024873
 protein coding gene Chr18:61839663-61858320 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022303
 protein coding gene Chr18:56946505-57132458 (+)
CAST/EiJ MGP_CASTEiJ_G0023666
 protein coding gene Chr18:59270627-59299052 (+)
CBA/J MGP_CBAJ_G0024164
 protein coding gene Chr18:63870073-63872909 (+)
DBA/2J MGP_DBA2J_G0024294
 protein coding gene Chr18:57301409-57304244 (+)
FVB/NJ MGP_FVBNJ_G0024260
 protein coding gene Chr18:56670084-56687046 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0027322
 protein coding gene Chr3:106149522-106159514 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024920
 protein coding gene Chr18:59359210-59375403 (+)
PWK/PhJ MGP_PWKPhJ_G0023409
 protein coding gene Chr18:57197353-57200427 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023215
 protein coding gene Chr18:59648694-59667193 (+)
WSB/EiJ MGP_WSBEiJ_G0023731
 protein coding gene Chr18:59228083-59246346 (+)



Homology
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Targeted deletion of this gene results in partial loss of IFN-gamma-mediated Toxoplasma gondii growth restriction in primary mouse astrocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    29
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    821
  • Tissues
    107
  • cDNA Data
    11
  • Literature Summary
    3
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054072 Ensembl Gene Model | MGI Sequence Detail 16608 C57BL/6J ±  kb
transcript ENSMUST00000066912 Ensembl | MGI Sequence Detail 2927 Not Applicable  
polypeptide ENSMUSP00000063390 Ensembl | MGI Sequence Detail 413 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
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  • All nucleic 14
    cDNA 11
    Primer pair 2
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGI:1920292, MGI:2147195, MGI:2147350
References
more
  • Summaries
    All 44
    Developmental Gene Expression 3
    Gene Ontology 13
    Phenotypes 6
  • Earliest
    J:64689 Boehm U, et al., Two families of GTPases dominate the complex cellular response to IFN-gamma. J Immunol. 1998 Dec 15;161(12):6715-23
  • Latest
    J:247338 Ferreira-da-Silva Mda F, et al., Identification of the microsporidian Encephalitozoon cuniculi as a new target of the IFNgamma-inducible IRG resistance system. PLoS Pathog. 2014 Oct;10(10):e1004449
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/28/2022
MGI 6.20 		The Jackson Laboratory