early conceptus |
embryo ectoderm |
embryo endoderm |
embryo mesoderm |
embryo mesenchyme |
extraembryonic component |
alimentary system |
auditory system |
branchial arches |
cardiovascular system |
connective tissue |
endocrine system |
exocrine system |
hemolymphoid system |
integumental system |
limbs |
liver and biliary system |
musculoskeletal system |
nervous system |
olfactory system |
reproductive system |
respiratory system |
urinary system |
visual system |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Transcription Start Site | Location | Distance from Gene 5'-end |
| Tssr151269 | Chr18:60509125-60509151 (+) | 39 bp |
| Tssr151270 | Chr18:60509198-60509216 (+) | 108 bp |
| Tssr151271 | Chr18:60509517-60509562 (+) | 441 bp |
| Tssr151272 | Chr18:60509589-60509617 (+) | 504 bp |
| Tssr151273 | Chr18:60509679-60509694 (+) | 588 bp |
| Tssr151274 | Chr18:60512245-60512272 (+) | 3,160 bp |
| Tssr151275 | Chr18:60512311-60512350 (+) | 3,232 bp |
| Tssr151276 | Chr18:60512534-60512546 (+) | 3,441 bp |
| Tssr151277 | Chr18:60515669-60515703 (+) | 6,587 bp |
| Tssr151278 | Chr18:60515786-60515819 (+) | 6,704 bp |
| Tssr151279 | Chr18:60516520-60516523 (+) | 7,423 bp |
| Tssr151280 | Chr18:60516732-60516738 (+) | 7,636 bp |
| Tssr151281 | Chr18:60518080-60518096 (+) | 8,989 bp |
| Tssr151282 | Chr18:60518775-60518777 (+) | 9,677 bp |
| Tssr151283 | Chr18:60519136-60519147 (+) | 10,043 bp |
| Tssr5341 | Chr18:60519262-60519273 (+) | 10,169 bp |
| Tssr151284 | Chr18:60522872-60522901 (+) | 13,788 bp |
| Tssr151285 | Chr18:60522914-60522936 (+) | 13,826 bp |
| Tssr151286 | Chr18:60523192-60523206 (+) | 14,100 bp |
| Tssr151287 | Chr18:60523253-60523262 (+) | 14,159 bp |
| Tssr151288 | Chr18:60523264-60523285 (+) | 14,176 bp |
| Tssr151289 | Chr18:60523533-60523555 (+) | 14,445 bp |
| Tssr151290 | Chr18:60523611-60523638 (+) | 14,526 bp |
| Tssr151291 | Chr18:60523703-60523713 (+) | 14,609 bp |
| Tssr151292 | Chr18:60523721-60523748 (+) | 14,636 bp |
| Tssr151293 | Chr18:60523900-60523916 (+) | 14,809 bp |
| Tssr151294 | Chr18:60523998-60524016 (+) | 14,908 bp |
| Tssr151295 | Chr18:60524225-60524258 (+) | 15,143 bp |
| Tssr151296 | Chr18:60524539-60524551 (+) | 15,446 bp |
| Tssr151297 | Chr18:60524559-60524566 (+) | 15,464 bp |
| Tssr151298 | Chr18:60524588-60524599 (+) | 15,495 bp |
| Tssr151299 | Chr18:60524600-60524607 (+) | 15,505 bp |
| Tssr151300 | Chr18:60524639-60524650 (+) | 15,546 bp |
| Tssr151301 | Chr18:60524665-60524676 (+) | 15,572 bp |
| Tssr151302 | Chr18:60524682-60524691 (+) | 15,588 bp |
| Tssr151303 | Chr18:60525113-60525158 (+) | 16,037 bp |
| Tssr151304 | Chr18:60525163-60525182 (+) | 16,074 bp |
| Tssr151305 | Chr18:60525331-60525347 (+) | 16,240 bp |
| QTL | Genetic Location* | Genome Location (GRCm39) | Reference | QTL Note |
| Par2 | Chr18, 44.19 cM | Chr18:70362333-76707156 | J:78525 | Microarray gene expression analysis was used to identify candidate genes for tumor resistant and tumor susceptibility QTLs Par8,2,3,4 and and Pas1-4, respectively. Transcripts found within the flanking markers of each QTL were identified and matched to transcripts from Affymetrix probe sets. RNA from A/J, BALB/cJ, C57BL/6J, and SM/J were used for analysis. Pas1 is located between 48.2 cM and 75 cM on mouse Chromosome 6 and was identified in a cross between A/J and C57BL/6J. Candidate oncogenic genes identified by microarray analysis are hes related protein (**Note- this gene is not found in MGD), Ppih (cyclophilin H **Note-this gene is positioned on mouse Chromosome 4 in MGD), Ptpro, Mglap, Recql, and Bcat1 (ECA39). Other candidate genes identified via differential expression are Ccnd2 (cyclin D2) and high mobility group protein 2A,4 (**Note-this gene is not found in MGD). K-ras, a positional candidate gene, did not show significantly different expression between A/J and C57BL/6J. Pas2 is located between 17 cMand 23.2 cM on mouse Chromosome 17 and was identified in crosses involving A/J and C57BL/6J. Candidate oncogenic genes identified by microarray analysis are Notch4, Hnrpk (**Note-this gene is positioned on mouse Chromosome 13 in MGD), and Enpp4. Other candidate genes identified via differential expression are Cdc5l, Tapbp (tapasin), H2-Ke2, Rbx1 (regulator of cullins 1 **Note- this gene is found on mouse Chromosome 15 in MGD), Psors1c2, H2-Ke6, and H2-M9. Positional candidate genes Tnf (Tnfa) and Lta (Tnfb) did not show significantly different expression between A/J and C57BL/6J. Pas3 is located between 2 cM and 25 cM on mouse Chromosome 19 and was identified in a cross between A/J and C57BL/6J. Candidate oncogenic genes identified by microarray analysis are golgi specific Gbf1 (brefeldin A resistance factor 1) and Sema4g. Other candidate genes identified via differential expression are Pdcd4, Adrb1, and Cdc25l. Pas4 is located between 42 cM and 72 cM on mouse Chromosome 9 and was identified in a cross between A/J and C57BL/6J. Candidate oncogenic genes identified by microarray analysis are Nck1, Pthr1, and Topbp1. Candidate tumor suppressor genes for Pas4 are G protein alpha I 2 (**Note-this gene is not found in MGD), Cdk5 (**Note-this gene is positioned on mouse Chromosome 5 in MGD), Smarcd3 (**Note-this gene is positioned on mouse Chromosome 5 in MGD), and Nckipsd. Another candidate gene identified via differential expression is Stag1. Par1 is located between 37 cM and 59 cM on mouse Chromosome 11 and was identified in a cross between A/J and SM/J. Candidate oncogenic genes identified by microarray analysis are Alox12 (12-lipoxygenase), Zfp617 (zinc finger protein s11-6), Grn, and Rpl29 (**Note-this gene is positioned on mouse Chromosome 9 in MGD). A tumor suppressor candidate gene for Par1 is Spop. 02.05.2016 Curator Note: Because Par1 was originally mapped in J:32079 using an (A/J x M. spretus) x C57BL/6J interspecific backcross, which differs from the cross used here, we have equated this QTL with Par8 which was mapped using A/J and SM/J mice, see J:41849. Par2 is located between 32 cM and 57 cM on mouse Chromosome 18 and was identified in a cross between A/J and BALB/cJ. Candidate oncogenic genes identified by microarray analysis are Adrb2, Mbd2, Htr4, Hmgb1-rs12, and Iigp1. Dcc is an expected candidate gene of Par2 but its expression pattern (A/J=high expression) is not consistent with its effect on tumor resistance/susceptibility. Mc2r is another candidate gene identified via differential gene expression between A/J and SM/J. Par3 is located between 13 cM and 44 cM on mouse Chromosome 12 and was identified in a cross between A/J and SM/J. Only one candidate oncogenic gene was identified for Par3. This is placental growth factor, Pgf. Par4 is located between 10.6 cM and 42.5 cM on mouse Chromosome 4 and was identified in a cross between A/J and BALB/cJ. Candidate tumor suppressor genes identified via differential gene expression are Cdkn2a, Egfl5, Ambp (bikunin), Pole3, Tyrp1, Ifnab, and Igfbpl1.Candidate oncogenes are T complex protein 1 alpha (**Note-this gene is not found in MGD) and Stmn1. Another candidate gene identified via differential expression between A/J and SM/J is Ptprd. |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/18/2025 MGI 6.24 |
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