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Gipc1
Gene Detail
 Symbol
Name
ID
Gipc1
GIPC PDZ domain containing family, member 1
MGI:1926252
Synonyms Glut1CIP, neurophilin1-IP, Rgs19ip1, Semcap1, synectin, TaxIP2, TIP-2
Feature Type protein coding gene
Genetic Map
Chromosome 8
40.22 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:83652678-83664788 bp, + strand
From Ensembl annotation of GRCm38

  12111 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21167  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: uncharacterized protein with PDZ domain, GIPC type
Gene Tree: Gipc1

Human
homologs
Human Homolog GIPC1, GIPC PDZ domain containing family, member 1
NCBI Gene ID 10755
neXtProt AC  NX_O14908
Human Synonyms  C19orf3, GIPC, GLUT1CBP, Hs.6454, IIP-1, NIP, RGS19IP1, SEMCAP, SYNECTIIN, SYNECTIN, TIP-2
Human Chr (Location)  19p13.1; chr19:14477759-14496149 (-)  GRCh38
Alleles
and
phenotypes
All alleles(51) : Gene trapped(48) Targeted(3)
 
Mice homozygous for a gene trapped allele display reduced body and heart weight, selective arteriogenesis and arterial endothelial cell defects, and impaired cardiac performance and wound healing. Mice homozygous for a knock-out allele exhibit low molecular weight proteinuria.
 
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process endothelial cell migration, glutamate secretion, ...
Component brush border, cell, ...
Function actin binding, GTPase activator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (55)    Tissues (35)    Images (3)
Theiler Stages: 6, 7, 9, 11, 12, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Northern blot 41
Western blot 14
cDNA source data(61)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(62) cDNA(62)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000019433 (Evidence)
Entrez Gene67903 (Evidence)
UniGene20945
DFCITC1574264
DoTSDT.55100372, DT.91343154
NIA Mouse Gene IndexU009557
Consensus CDS ProjectCCDS22457.1
International Mouse Knockout Project StatusGipc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019433 Ensembl Gene Model | MGI Sequence Detail 12111 C57BL/6J ±  kb
transcript ENSMUST00000019577 Ensembl | MGI Sequence Detail 1615 Not Applicable 
polypeptide ENSMUSP00000019577 Ensembl | MGI Sequence Detail 333 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(122 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
InterPro IPR017379 Uncharacterised conserved protein UCP038083, PDZ
Protein Ontology PR:000007987 PDZ domain-containing protein GIPC1
References (Earliest) J:64809 De Vries L, et al., GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12340-5
(Latest) J:200496 Wu C, et al., Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis. J Biol Chem. 2011 Jul 1;286(26):23511-20
All references(51)
Other
accession IDs
MGI:1861792

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory