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Car5b Gene Detail
Summary
  • Symbol
    Car5b
  • Name
    carbonic anhydrase 5b, mitochondrial
  • Synonyms
    7330410H16Rik, CAVB, D730005F19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926249
    NCBI Gene: 56078
  • Gene Overview
    MyGene.info: CA5B
Location & Maps
more
  • Sequence Map
    ChrX:163976822-164027997 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51176 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CA5B, carbonic anhydrase 5B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CA5B, carbonic anhydrase 5B
    Orthology source: HomoloGene
  • Synonyms
    CA-VB
  • Links
    NCBI Gene ID: 11238
    neXtProt AC: NX_Q9Y2D0

  • Chr Location
    Xp21.1; chrX:15738250-15787625 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    7 phenotype references
Mice that are either homozygous or hemizygous for a knock-out allele exhibit normal survival and show no detectable differences in blood ammonia or fasting glucose levels relative to control littermates.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019511 VEGA Gene Model | MGI Sequence Detail 51176 C57BL/6J ±  kb
transcript OTTMUST00000046594 VEGA | MGI Sequence Detail 3436 Not Applicable  
polypeptide OTTMUSP00000021042 VEGA | MGI Sequence Detail 317 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    164 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000004922 carbonic anhydrase 5B, mitochondrial
  • EC
  • InterPro Domains
    IPR001148 Alpha carbonic anhydrase
    IPR023561 Carbonic anhydrase, alpha-class
    IPR018338 Carbonic anhydrase, alpha-class, conserved site
    IPR018437 Carbonic anhydrase VB, mitochondria
Molecular
Reagents
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  • All nucleic 29
    cDNA 28
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
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MGI:1925347, MGI:1926092
References
more
  • Summaries
    All 32
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:64692 Shah GN, et al., Mitochondrial carbonic anhydrase CA VB: differences in tissue distribution and pattern of evolution from those of CA VA suggest distinct physiological roles. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1677-82
  • Latest
    J:196135 Shah GN, et al., Targeted mutagenesis of mitochondrial carbonic anhydrases VA and VB implicates both enzymes in ammonia detoxification and glucose metabolism. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7423-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory