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Car5b
Gene Detail
 Symbol
Name
ID
Car5b
carbonic anhydrase 5b, mitochondrial
MGI:1926249
Synonyms 7330410H16Rik, CAVB, D730005F19Rik
Feature Type protein coding gene
Genetic Map
Chromosome X
76.03 cM, cytoband F5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:163976822-164027997 bp, - strand
From VEGA annotation of GRCm38

  51176 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21413  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: carbonate dehydratase
Gene Tree: Car5b

Human
homologs
Human Homolog CA5B, carbonic anhydrase VB, mitochondrial
NCBI Gene ID 11238
neXtProt AC  NX_Q9Y2D0
Human Synonyms  CA-VB
Human Chr (Location)  Xp21.1; chrX:15738289-15787625 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice that are either homozygous or hemizygous for a knock-out allele exhibit normal survival and show no detectable differences in blood ammonia or fasting glucose levels relative to control littermates.
 
Interactions
Car5b interacts with 280 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process one-carbon metabolic process
Component mitochondrion
Function carbonate dehydratase activity, lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (98)    Tissues (97)    Images (3)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 98
cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) cDNA(28) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000019511 (Evidence)
Ensembl Gene ModelENSMUSG00000031373 (Evidence)
Entrez Gene56078 (Evidence)
UniGene180953
DFCITC1585387, TC1618412, TC1626869, TC1635730
DoTSDT.60104394, DT.87072303, DT.91325973
NIA Mouse Gene IndexU039855
EC4.2.1.1
Consensus CDS ProjectCCDS30515.1
International Mouse Knockout Project StatusCar5b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019511 VEGA Gene Model | MGI Sequence Detail 51176 C57BL/6J ±  kb
transcript OTTMUST00000046594 VEGA | MGI Sequence Detail 3436 Not Applicable 
polypeptide OTTMUSP00000021042 VEGA | MGI Sequence Detail 317 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(168 from dbSNP Build 137)    SNPs within 2kb including multiple locations(174)
Protein-related
information
ResourceIDDescription
InterPro IPR001148 Alpha carbonic anhydrase
InterPro IPR023561 Carbonic anhydrase, alpha-class
InterPro IPR018338 Carbonic anhydrase, alpha-class, conserved site
InterPro IPR018437 Carbonic anhydrase V, mitochondria
Protein Ontology PR:000004922 carbonic anhydrase 5B, mitochondrial
References (Earliest) J:64692 Shah GN, et al., Mitochondrial carbonic anhydrase CA VB: differences in tissue distribution and pattern of evolution from those of CA VA suggest distinct physiological roles. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1677-82
(Latest) J:196135 Shah GN, et al., Targeted mutagenesis of mitochondrial carbonic anhydrases VA and VB implicates both enzymes in ammonia detoxification and glucose metabolism. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7423-8
All references(36)
Other
accession IDs
MGI:1925347, MGI:1926092

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory