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Ube2j1 Gene Detail
Summary
  • Symbol
    Ube2j1
  • Name
    ubiquitin-conjugating enzyme E2J 1
  • Synonyms
    0710008M05Rik, 1110030I22Rik, Ncube, Ubc6p
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926245
    NCBI Gene: 56228
  • Gene Overview
    MyGene.info: UBE2J1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:33031416-33052363 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 14.61 cM, cytoband A5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    209 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926245
protein coding gene Chr4:33031387-33052364 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028117
protein coding gene Chr4:30524151-30545431 (+)
A/J MGP_AJ_G0028075
protein coding gene Chr4:29432798-29454131 (+)
AKR/J MGP_AKRJ_G0028038
protein coding gene Chr4:30201022-30221845 (+)
BALB/cJ MGP_BALBcJ_G0028086
protein coding gene Chr4:29695733-29717453 (+)
C3H/HeJ MGP_C3HHeJ_G0027815
protein coding gene Chr4:30488237-30509242 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028528
protein coding gene Chr4:31720939-31742868 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025869
protein coding gene Chr4:27498820-27519956 (+)
CAST/EiJ MGP_CASTEiJ_G0027270
protein coding gene Chr4:30265935-30287924 (+)
CBA/J MGP_CBAJ_G0027787
protein coding gene Chr4:32753940-32777523 (+)
DBA/2J MGP_DBA2J_G0027931
protein coding gene Chr4:29436374-29457229 (+)
FVB/NJ MGP_FVBNJ_G0027897
protein coding gene Chr4:28861951-28883846 (+)
LP/J MGP_LPJ_G0028039
protein coding gene Chr4:30615539-30637060 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027930
protein coding gene Chr4:35318135-35339887 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028587
protein coding gene Chr4:30210539-30232191 (+)
PWK/PhJ MGP_PWKPhJ_G0026989
protein coding gene Chr4:29436312-29457570 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026818
protein coding gene Chr4:30098328-30119353 (+)
WSB/EiJ MGP_WSBEiJ_G0027346
protein coding gene Chr4:30208167-30228553 (+)



Homology
more
  • Human Ortholog
    UBE2J1, ubiquitin conjugating enzyme E2 J1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UBE2J1, ubiquitin conjugating enzyme E2 J1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CGI-76, HSPC153, HSPC205, HSU93243, NCUBE1, NCUBE-1, UBC6, UBC6E, Ubc6p
  • Links
    NCBI Gene ID: 51465
    neXtProt AC: NX_Q9Y385
    UniProt: Q9Y385

  • Chr Location
    6q15; chr6:89326625-89352917 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 41090
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: UBE2J1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    3 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial postnatal lethality, decreased body size, and male infertility associated with defective spermiogenesis, teratozoospermia, and asthenozoospermia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028277 Ensembl Gene Model | MGI Sequence Detail 20948 C57BL/6J ±  kb
    transcript ENSMUST00000124992 Ensembl | MGI Sequence Detail 3530 Not Applicable  
    polypeptide ENSMUSP00000118333 Ensembl | MGI Sequence Detail 318 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 95
      cDNA 95

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1915675, MGI:1915927
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:64685 Lester D, et al., Identification of a family of noncanonical ubiquitin-conjugating enzymes structurally related to yeast UBC6. Biochem Biophys Res Commun. 2000 Mar 16;269(2):474-80
    • Latest
      J:252992 Hagiwara M, et al., Posttranscriptional Regulation of Glycoprotein Quality Control in the Endoplasmic Reticulum Is Controlled by the E2 Ub-Conjugating Enzyme UBC6e. Mol Cell. 2016 Sep 1;63(5):753-67

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory