Dexi Gene Detail

Summary

• Symbol
  Dexi
• Name
  dexamethasone-induced transcript
• Synonyms
  1810029J14Rik, D16Bwg0586e

• Feature Type
  protein coding gene
• IDs
  MGI:1926236
  NCBI Gene: 58239
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr16:10348071-10360918 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 16, 5.67 cM
• Mapping Data
  5 experiments

Strain
Comparison

• SNPs within 2kb
  91 from dbSNP Build 142
• Strain Annotations
  18
• PCR
  1

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926236	protein coding gene	Chr16:10320395-10360918 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022509	protein coding gene	Chr16:7308576-7351217 (-)
A/J	MGP_AJ_G0022471	protein coding gene	Chr16:6905369-6950683 (-)
AKR/J	MGP_AKRJ_G0022447	protein coding gene	Chr16:7229751-7270152 (-)
BALB/cJ	MGP_BALBcJ_G0022475	protein coding gene	Chr16:7040937-7083452 (-)
C3H/HeJ	MGP_C3HHeJ_G0022242	protein coding gene	Chr16:7305221-7346486 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022924	protein coding gene	Chr16:7458588-7502848 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020445	protein coding gene	Chr16:7050809-7092093 (-)
CAST/EiJ	MGP_CASTEiJ_G0021769	protein coding gene	Chr16:7321562-7365292 (-)
CBA/J	MGP_CBAJ_G0022211	protein coding gene	Chr16:7785072-7829022 (-)
DBA/2J	MGP_DBA2J_G0022342	protein coding gene	Chr16:6916293-6956988 (-)
FVB/NJ	MGP_FVBNJ_G0022318	protein coding gene	Chr16:6898322-6940178 (-)
LP/J	MGP_LPJ_G0022410	protein coding gene	Chr16:7266145-7309712 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022340	protein coding gene	Chr16:7523891-7567435 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022937	protein coding gene	Chr16:7174224-7217198 (-)
PWK/PhJ	MGP_PWKPhJ_G0021509	protein coding gene	Chr16:7119596-7161441 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021339	protein coding gene	Chr16:7240484-7281543 (-)
WSB/EiJ	MGP_WSBEiJ_G0021817	protein coding gene	Chr16:7250333-7292607 (-)

Homology

• Human Ortholog
  DEXI, Dexi homolog

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  DEXI, Dexi homolog
  
• Synonyms
  MYLE
• Links
  HGNC:13267

  NCBI Gene ID: 28955

  neXtProt AC: NX_O95424

  UniProt: O95424

  
  
• Chr Location
  16p13.13; chr16:10928891-10943007 (-)  GRCh38.p7

---

• Alliance of Genome Resources
  Dexi stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: DEXI
• Gene Tree
  Dexi
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  1 phenotype from multigenic genotypes
  5 phenotype references
  

• All Mutations and Alleles
  5
• Endonuclease-mediated
  2
• Gene trapped
  3
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  9 strains or lines available

Mice homozygous for a knock-out allele exhibit normal response to poly I:C and susceptibility to diabetes.

Expression

• Assay Results
  707
• Tissues
  1
• cDNA Data
  33
• Literature Summary
  1

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Interactions

• Dexi interacts with 120 markers (Mir30a, Mir30b, Mir30c-1, ...) View All

Sequences &
Gene Models

• All Sequences
  38
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS37252.1

• Ensembl
  ENSMUSG00000038055 (Evidence)
• NCBI Gene
  58239

Representative Sequences			Length	Strain/Species
genomic	58239	NCBI Gene Model | MGI Sequence Detail	12848	C57BL/6J
transcript	NM_021428	RefSeq | MGI Sequence Detail	1394	C57BL/6
polypeptide	Q9WUQ7	UniProt | EBI | MGI Sequence Detail	95	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000006429 dexamethasone-induced protein
  (term hierarchy)
• InterPro Domains
  IPR023259 Dexamethasone-induced protein

Molecular
Reagents

• All nucleic 36

  cDNA 34

  Primer pair 2

  
  

  Microarray probesets 4

Other
Accession IDs

MGD-MRK-33992, MGI:106300, MGI:1916391, MGI:2146487, MGI:2146637

References

• Summaries
  All 32

  Developmental Gene Expression 1

  Phenotypes 5
• Earliest
  J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
• Latest
  J:285312 Nieves-Bonilla JM, et al., The type 1 diabetes candidate gene Dexi does not affect disease risk in the nonobese diabetic mouse model. Genes Immun. 2020 Jan;21(1):71-77

TSS for Dexi:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139926	Chr16:10360892-10360960 (-)	-8 bp