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Tmem27
Gene Detail
Symbol

Name
ID
Tmem27
transmembrane protein 27
MGI:1926234
Synonyms
0610008J07Rik, collectrin, NX17, NX=17
Feature Type
protein coding gene
Genetic Map
Chromosome X
76.12 cM, cytoband F5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:164088830-164118860 bp, + strand
From VEGA annotation of GRCm38

  30031 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10767  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TMEM27
Gene Tree: Tmem27

Human
homologs
TMEM27, transmembrane protein 27
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 57393
neXtProt AC: NX_Q9HBJ8

Human Synonyms: NX17, NX-17

Human Chr (Location): Xp22; chrX:15627316-15665031 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(5) Targeted(6)
Incidental mutations (data from CvDC )
 
Homozygous mutation of this gene result in defects in renal amino acid uptake.
 
Interactions
Tmem27 interacts with 126 markers (Mir7-1, Mir10a, Mir16-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (29)    Tissues (28)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 29
cDNA source data(99)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tmem27    NEW 
Molecular
reagents
All nucleic(99) cDNA(99)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000019509 (Evidence)
Ensembl Gene Model ENSMUSG00000015401 (Evidence)
Entrez Gene 57394 (Evidence)
UniGene 143766
DFCI TC1574801
DoTS DT.492354
NIA Mouse Gene Index U020382
Consensus CDS Project CCDS30517.1
International Mouse Phenotyping Consortium Status Tmem27
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019509 VEGA Gene Model | MGI Sequence Detail 30031 C57BL/6J ±  kb
transcript OTTMUST00000046591 VEGA | MGI Sequence Detail 1389 Not Applicable 
polypeptide OTTMUSP00000021040 VEGA | MGI Sequence Detail 222 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(129 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001548 Peptidase M2, peptidyl-dipeptidase A
Protein Ontology PR:000016422 collectrin
References
(Earliest) J:65057 Zhang H, et al., Screening for genes up-regulated in 5/6 nephrectomized mouse kidney. Kidney Int. 1999 Aug;56(2):549-58
(Latest) J:219167 Cechova S, et al., Loss of collectrin, an angiotensin-converting enzyme 2 homolog, uncouples endothelial nitric oxide synthase and causes hypertension and vascular dysfunction. Circulation. 2013 Oct 15;128(16):1770-80
All references(45)
Other
accession IDs
MGI:1915565

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory