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Tdh Gene Detail
Summary
  • Symbol
    Tdh
  • Name
    L-threonine dehydrogenase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926231
    NCBI Gene: 58865
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:63492347-63509092 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 33.31 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926231
protein coding gene Chr14:63492347-63509092 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021462
protein coding gene Chr14:58017622-58034357 (-)
A/J MGP_AJ_G0021421
protein coding gene Chr14:56702201-56719196 (-)
AKR/J MGP_AKRJ_G0021397
protein coding gene Chr14:58713482-58730171 (-)
BALB/cJ MGP_BALBcJ_G0021427
protein coding gene Chr14:56657991-56674678 (-)
C3H/HeJ MGP_C3HHeJ_G0021204
protein coding gene Chr14:58326173-58348404 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021866
protein coding gene Chr14:60766696-60784322 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019406
protein coding gene Chr14:54643227-54660220 (-)
CAST/EiJ MGP_CASTEiJ_G0020721
protein coding gene Chr14:54791973-54808620 (-)
CBA/J MGP_CBAJ_G0021171
protein coding gene Chr14:62583511-62602896 (-)
DBA/2J MGP_DBA2J_G0021294
protein coding gene Chr14:56375222-56391945 (-)
FVB/NJ MGP_FVBNJ_G0021273
protein coding gene Chr14:55761981-55778670 (-)
LP/J MGP_LPJ_G0021369
protein coding gene Chr14:59041789-59058516 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021302
protein coding gene Chr14:61814620-61831309 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021889
protein coding gene Chr14:57865774-57882461 (-)
PWK/PhJ MGP_PWKPhJ_G0020465
protein coding gene Chr14:53048094-53065254 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020298
protein coding gene Chr14:53837106-53855069 (-)
WSB/EiJ MGP_WSBEiJ_G0020774
protein coding gene Chr14:58191522-58210383 (-)



Homology
more
  • Human Ortholog
    TDH, L-threonine dehydrogenase (pseudogene)
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TDH, L-threonine dehydrogenase (pseudogene)
    Orthology source: HGNC
  • Synonyms
    SDR14E1P
  • Links
    NCBI Gene ID: 157739
    UniProt: Q8IZJ6

  • Chr Location
    8p23.1; chr8:11339637-11368452 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 58865 NCBI Gene Model | MGI Sequence Detail 16746 C57BL/6J ±  kb
transcript NM_021480 RefSeq | MGI Sequence Detail 1900 C57BL/6  
polypeptide Q8K3F7 UniProt | EBI | MGI Sequence Detail 373 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 34
    cDNA 32
    Primer pair 2

    Microarray probesets 6
References
more
  • Summaries
    All 38
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
  • Latest
    J:246734 Donato V, et al., The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells. Nat Cell Biol. 2017 Apr;19(4):341-351

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory