Treh MGI Mouse Gene Detail - MGI:1926230 - trehalase (brush-border membrane glycoprotein)

Symbol

Treh
Name

trehalase (brush-border membrane glycoprotein)
Synonyms

2210412M19Rik

Feature Type

protein coding gene
IDs

MGI:1926230
NCBI Gene: 58866
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:44584530-44597602 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 24.84 cM
Mapping Data

3 experiments

SNPs within 2kb

185 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926230	protein coding gene	Chr9:44584530-44597602 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034715	protein coding gene	Chr9:43196357-43210412 (+)
A/J	MGP_AJ_G0034696	protein coding gene	Chr9:41976483-41989776 (+)
AKR/J	MGP_AKRJ_G0034623	protein coding gene	Chr9:42850752-42863797 (+)
BALB/cJ	MGP_BALBcJ_G0034687	protein coding gene	Chr9:41723185-41736290 (+)
C3H/HeJ	MGP_C3HHeJ_G0034398	protein coding gene	Chr9:43303829-43316948 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035208	protein coding gene	Chr9:44472005-44485056 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032123	protein coding gene	Chr9:41547271-41560919 (+)
CAST/EiJ	MGP_CASTEiJ_G0033720	protein coding gene	Chr9:43164399-43178879 (+)
CBA/J	MGP_CBAJ_G0034370	protein coding gene	Chr9:46094227-46107268 (+)
DBA/2J	MGP_DBA2J_G0034529	protein coding gene	Chr9:41880502-41893597 (+)
FVB/NJ	MGP_FVBNJ_G0034470	protein coding gene	Chr9:41140659-41153719 (+)
LP/J	MGP_LPJ_G0034610	protein coding gene	Chr9:43493733-43506810 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034514	protein coding gene	Chr9:47928175-47941255 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035229	protein coding gene	Chr9:42766440-42780678 (+)
PWK/PhJ	MGP_PWKPhJ_G0033425	protein coding gene	Chr9:41764890-41778234 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033261	protein coding gene	Chr9:43075200-43088155 (+)
WSB/EiJ	MGP_WSBEiJ_G0033833	protein coding gene	Chr9:42794456-42807508 (+)

Human Ortholog

TREH, trehalase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TREH, trehalase
Synonyms

TRE, TREA, TREHD
Links

HGNC:12266

NCBI Gene ID: 11181

neXtProt AC: NX_O43280

UniProt: O43280
Chr Location

11q23.3; chr11:118657316-118679690 (-) GRCh38

MGI Vertebrate Homology

Treh stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TREH
Gene Tree

Treh

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available

Mice homozygous for a knock-out allele fail to exhibit a rapid increase in blood glucose levels following oral trehalose administration.

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All GO Annotations

11
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

16
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase treh

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All Sequences

50
RefSeq

12
UniProt

5
CCDS

CCDS23117.1, CCDS72222.1

Ensembl

ENSMUSG00000032098 (Evidence)
NCBI Gene

58866

			Length	Strain/Species	Flank
genomic	58866	NCBI Gene Model \| MGI Sequence Detail	13073	C57BL/6J	± kb
transcript	NM_021481	RefSeq \| MGI Sequence Detail	2053	C57BL/6
polypeptide	Q9JLT2	UniProt \| EBI \| MGI Sequence Detail	576	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000016624 trehalase

(term hierarchy)
EC

3.2.1.28
InterPro Domains

IPR001661 Glycoside hydrolase, family 37

IPR018232 Glycoside hydrolase, family 37, conserved site

IPR012341 Six-hairpin glycosidase-like superfamily

IPR008928 Six-hairpin glycosidase superfamily

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All nucleic 17

cDNA 16

Primer pair 1

Microarray probesets 2

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MGI:1914360

Summaries

All 39

Developmental Gene Expression 5

Gene Ontology 7

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:331975 Bara AM, et al., Maf family transcription factors are required for nutrient uptake in the mouse neonatal gut. Development. 2022 Dec 1;149(23):dev201251

TSS for Treh:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84693	Chr9:44584482-44584485 (+)	-46 bp
Tssr84694	Chr9:44584524-44584543 (+)	4 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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