About   Help   FAQ
Treh
Gene Detail
 Symbol
Name
ID
Treh
trehalase (brush-border membrane glycoprotein)
MGI:1926230
Synonyms 2210412M19Rik
Feature Type protein coding gene
Genetic Map
Chromosome 9
24.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:44673233-44686305 bp, + strand
From VEGA annotation of GRCm38

  13073 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5198  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: trehalase
Gene Tree: Treh

Human
homologs
Human Homolog TREH, trehalase (brush-border membrane glycoprotein)
NCBI Gene ID 11181
neXtProt AC  NX_O43280
Human Synonyms  TRE, TREA
Human Chr (Location)  11q23.3; chr11:118658232-118679672 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TREH
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele fail to exhibit a rapid increase in blood glucose levels following oral trehalose administration.
 
Interactions
Treh interacts with 198 markers (Mir1a-1, Mir1a-2, Mir16-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process metabolic process, organ morphogenesis, ...
Component anchored component of membrane, brush border, ...
Function alpha,alpha-trehalase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (94)    Tissues (94)    Images (6)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000033497 (Evidence)
Ensembl Gene ModelENSMUSG00000032098 (Evidence)
Entrez Gene58866 (Evidence)
UniGene45380
DFCITC1585849, TC1593276
DoTSDT.55179628, DT.97390334
NIA Mouse Gene IndexU010399
EC3.2.1.28
Consensus CDS ProjectCCDS23117.1, CCDS72222.1
International Mouse Knockout Project StatusTreh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033497 VEGA Gene Model | MGI Sequence Detail 13073 C57BL/6J ±  kb
transcript OTTMUST00000084250 VEGA | MGI Sequence Detail 2048 Not Applicable 
polypeptide OTTMUSP00000045378 VEGA | MGI Sequence Detail 576 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(14) UniProt(5)
Polymorphisms SNPs within 2kb(185 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001661 Glycoside hydrolase, family 37
InterPro IPR018232 Glycoside hydrolase, family 37, conserved site
InterPro IPR008928 Six-hairpin glycosidase-like
Protein Ontology PR:000016624 trehalase
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205646 Muncan V, et al., Blimp1 regulates the transition of neonatal to adult intestinal epithelium. Nat Commun. 2011;2:452
All references(36)
Other
accession IDs
MGI:1914360

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory