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Rbfox1 Gene Detail
Summary
  • Symbol
    Rbfox1
  • Name
    RNA binding protein, fox-1 homolog (C. elegans) 1
  • Synonyms
    A2bp, A2bp1, FOX1, HRNBP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926224
    NCBI Gene: 268859
  • Gene Overview
    MyGene.info: RBFOX1
  • Alliance
    gene page
  • Transcription Start Sites
    29 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:5885355-7411526 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 3.34 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    20342 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926224
 protein coding gene Chr16:5884793-7412480 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022490
 protein coding gene Chr16:3429752-4069285 (+)
A/J MGP_AJ_G0022452
 protein coding gene Chr16:3182139-3801677 (+)
AKR/J MGP_AKRJ_G0022429
 protein coding gene Chr16:3413469-4039694 (+)
BALB/cJ MGP_BALBcJ_G0022457
 protein coding gene Chr16:3333458-3945668 (+)
C3H/HeJ MGP_C3HHeJ_G0022224
 protein coding gene Chr16:3423402-4031042 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022906
 protein coding gene Chr16:3512693-4137041 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020427
 protein coding gene Chr16:3068624-3671166 (+)
CAST/EiJ MGP_CASTEiJ_G0021750
 protein coding gene Chr16:3466958-4100314 (+)
CBA/J MGP_CBAJ_G0022193
 protein coding gene Chr16:3706259-4362225 (+)
DBA/2J MGP_DBA2J_G0022324
 protein coding gene Chr16:3234244-3850517 (+)
FVB/NJ MGP_FVBNJ_G0022299
 protein coding gene Chr16:3237047-3850908 (+)
LP/J MGP_LPJ_G0022392
 protein coding gene Chr16:3393463-4040146 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022321
 protein coding gene Chr16:3514609-4149610 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022918
 protein coding gene Chr16:3379863-4004963 (+)
PWK/PhJ MGP_PWKPhJ_G0021490
 protein coding gene Chr16:3390551-4005556 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021321
 protein coding gene Chr16:3455679-4082114 (+)
WSB/EiJ MGP_WSBEiJ_G0021799
 protein coding gene Chr16:3402139-4025924 (+)



Homology
more
  • Human Ortholog
    RBFOX1, RNA binding fox-1 homolog 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RBFOX1, RNA binding fox-1 homolog 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    2BP1, A2BP1, FOX1, FOX-1, HRNBP1
  • Links
    NCBI Gene ID: 54715
    neXtProt AC: NX_Q9NWB1
    UniProt: Q9NWB1

  • Chr Location
    16p13.3; chr16:5239749-7713343 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    10 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in the brain exhibit reduced fertility, infrequent spontaneous seizures, increased susceptibility to kainic acid-induced seizures and lethality, and increased neuronal excitation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    237
  • Tissues
    53
  • cDNA Data
    16
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000008658 Ensembl Gene Model | MGI Sequence Detail 1526172 C57BL/6J ±  kb
    transcript ENSMUST00000229741 Ensembl | MGI Sequence Detail 1407 Not Applicable  
    polypeptide ENSMUSP00000155364 Ensembl | MGI Sequence Detail 417 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 16
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 15
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:70808 Kiehl TR, et al., Identification and expression of a mouse ortholog of A2BP1. Mamm Genome. 2001 Aug;12(8):595-601
    • Latest
      J:265044 Parras A, et al., Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing. Nature. 2018 Aug;560(7719):441-446
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/06/2018
    MGI 6.13     		The Jackson Laboratory