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Tnip1
Gene Detail
Symbol

Name
ID
Tnip1
TNFAIP3 interacting protein 1
MGI:1926194
Synonyms
A20-binding inhibitor of NF-kappa B activation, ABIN1, Nef, VAN
Feature Type
protein coding gene
Genetic Map
Chromosome 11
32.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:54910787-54962917 bp, - strand
From VEGA annotation of GRCm38

  52131 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31355  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Nef-associated factor 1
Gene Tree: Tnip1

Human
homologs
Human Homolog TNIP1, TNFAIP3 interacting protein 1
NCBI Gene ID 10318
neXtProt AC  NX_Q15025
Human Synonyms  ABIN-1, NAF1, nip40-1, VAN
Human Chr (Location)  5q32-q33.1; chr5:151029943-151087660 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(70) : Gene trapped(61) Targeted(9)
Genomic Mutations involving Tnip1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit perinatal lethality associated with anemia and focal apoptosis in the fetal liver. Mice homozygous for a gene trap allele exhibit partial prenatal lethality and SLE-like inflammatory disease.
 
Phenotype Images(3)
Interactions
Tnip1 interacts with 143 markers (Mir18, Mir18b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process glycoprotein biosynthetic process, inflammatory response, ...
Component cytoplasm, nucleus
Function mitogen-activated protein kinase binding, polyubiquitin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (10)    Tissues (6)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 10
cDNA source data(73)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(73) cDNA(73)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006334 (Evidence)
Ensembl Gene ModelENSMUSG00000020400 (Evidence)
Entrez Gene57783 (Evidence)
UniGene259671
DFCITC1576140, TC1590091, TC1619180, TC1686349
DoTSDT.101388080, DT.103597426, DT.110547951, DT.87050728, DT.91401936, DT.99857883
NIA Mouse Gene IndexU032784
Consensus CDS ProjectCCDS24704.1, CCDS56769.1, CCDS70188.1
International Mouse Knockout Project StatusTnip1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006334 VEGA Gene Model | MGI Sequence Detail 52131 C57BL/6J ±  kb
transcript OTTMUST00000014391 VEGA | MGI Sequence Detail 2810 Not Applicable 
polypeptide OTTMUSP00000006672 VEGA | MGI Sequence Detail 647 Not Applicable 

For the selected sequences
All sequences(124) RefSeq(18) UniProt(7)
Polymorphisms
SNPs within 2kb(450 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000016492 TNFAIP3-interacting protein 1
References
(Earliest) J:64942 Heyninck K, et al., The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. J Cell Biol. 1999 Jun 28;145(7):1471-82
(Latest) J:205446 Callahan JA, et al., Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells. J Immunol. 2013 Jul 15;191(2):535-9
All references(43)
Other
accession IDs
MGI:2144384

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory