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Chsy3 Gene Detail
Summary
  • Symbol
    Chsy3
  • Name
    chondroitin sulfate synthase 3
  • Synonyms
    4833446K15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926173
    NCBI Gene: 78923
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:59308412-59544408 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 18, 33.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2217 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926173
protein coding gene Chr18:59308412-59669071 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024457
protein coding gene Chr18:58764036-59012082 (+)
A/J MGP_AJ_G0024423
protein coding gene Chr18:56367098-56609507 (+)
AKR/J MGP_AKRJ_G0024393
protein coding gene Chr18:57914088-58167161 (+)
BALB/cJ MGP_BALBcJ_G0024423
protein coding gene Chr18:56518574-56755348 (+)
C3H/HeJ MGP_C3HHeJ_G0024190
protein coding gene Chr18:58136488-58387493 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024869
protein coding gene Chr18:60571128-60819920 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022301
protein coding gene Chr18:55907512-56147363 (+)
CAST/EiJ MGP_CASTEiJ_G0023664
protein coding gene Chr18:58156732-58534265 (+)
CBA/J MGP_CBAJ_G0024160
protein coding gene Chr18:62538493-62811042 (+)
DBA/2J MGP_DBA2J_G0024290
protein coding gene Chr18:56067782-56308360 (+)
FVB/NJ MGP_FVBNJ_G0024257
protein coding gene Chr18:55435658-55671170 (+)
LP/J MGP_LPJ_G0024375
protein coding gene Chr18:58673510-58931922 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024287
protein coding gene Chr18:64041591-64323649 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024916
protein coding gene Chr18:58059774-58298734 (+)
PWK/PhJ MGP_PWKPhJ_G0023408
protein coding gene Chr18:56093688-56447199 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023214
protein coding gene Chr18:58119897-58372520 (+)
WSB/EiJ MGP_WSBEiJ_G0023727
protein coding gene Chr18:57951293-58195149 (+)



Homology
more
  • Human Ortholog
    CHSY3, chondroitin sulfate synthase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHSY3, chondroitin sulfate synthase 3
  • Synonyms
    CHSY2, CSS3
  • Links
    NCBI Gene ID: 337876
    neXtProt AC: NX_Q70JA7
    UniProt: Q70JA7

  • Chr Location
    5q23.3; chr5:129903979-130186634 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 3 alleles in 3 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit short tibia and femur.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 78923 NCBI Gene Model | MGI Sequence Detail 235997 C57BL/6J ±  kb
    transcript NM_001081328 RefSeq | MGI Sequence Detail 3882 Not Specified  
    polypeptide Q5DTK1 UniProt | EBI | MGI Sequence Detail 884 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 9
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147256
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 5
    • Earliest
      J:324068 Silbert JE, et al., Biosynthesis of chondroitin sulphate by a Golgi-apparatus-enriched preparation from cultures of mouse mastocytoma cells. Biochem J. 1980 Aug 15;190(2):307-13
    • Latest
      J:339242 Hu B, et al., Sensory Nerve Maintains Intervertebral Disc Extracellular Matrix Homeostasis Via CGRP/CHSY1 Axis. Adv Sci (Weinh). 2022 Oct;9(30):e2202620

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory