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Dlst Gene Detail
Summary
  • Symbol
    Dlst
  • Name
    dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
  • Synonyms
    1600017E01Rik, 4632413C10Rik, 4930529O08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926170
    NCBI Gene: 78920
  • Gene Overview
    MyGene.info: DLST
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:85110821-85134091 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 39.55 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    89 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926170
protein coding gene Chr12:85110821-85134845 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019952
protein coding gene Chr12:85867083-85893064 (+)
A/J MGP_AJ_G0019909
protein coding gene Chr12:82614184-82640370 (+)
AKR/J MGP_AKRJ_G0019885
protein coding gene Chr12:84838771-84865301 (+)
BALB/cJ MGP_BALBcJ_G0019889
protein coding gene Chr12:82947703-82974774 (+)
C3H/HeJ MGP_C3HHeJ_G0019695
protein coding gene Chr12:85319106-85343106 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020340
protein coding gene Chr12:88340968-88366782 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017958
protein coding gene Chr12:79500068-79522838 (+)
CAST/EiJ MGP_CASTEiJ_G0019244
protein coding gene Chr12:80291371-80316752 (+)
CBA/J MGP_CBAJ_G0019666
protein coding gene Chr12:91736387-91765740 (+)
DBA/2J MGP_DBA2J_G0019781
protein coding gene Chr12:82130104-82153230 (+)
FVB/NJ MGP_FVBNJ_G0019767
protein coding gene Chr12:81090619-81114445 (+)
LP/J MGP_LPJ_G0019853
protein coding gene Chr12:85744429-85769308 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019806
protein coding gene Chr12:94611390-94635856 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020374
protein coding gene Chr12:84449282-84475020 (+)
PWK/PhJ MGP_PWKPhJ_G0019008
protein coding gene Chr12:76621147-76644869 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018803
protein coding gene Chr12:78930440-78957141 (+)
WSB/EiJ MGP_WSBEiJ_G0019296
protein coding gene Chr12:85170537-85193454 (+)



Homology
more
  • Human Ortholog
    DLST, dihydrolipoamide S-succinyltransferase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DLST, dihydrolipoamide S-succinyltransferase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DLTS
  • Links
    NCBI Gene ID: 1743
    neXtProt AC: NX_P36957
    UniProt: P36957

  • Chr Location
    14q24.3; chr14:74881891-74903747 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from multigenic genotypes
    12 phenotype references
Mice heterozygous for a gene trap allele exhibit an accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 78920 NCBI Gene Model | MGI Sequence Detail 23271 C57BL/6J ±  kb
transcript NM_030225 RefSeq | MGI Sequence Detail 2767 C57BL/6  
polypeptide Q9D2G2 UniProt | EBI | MGI Sequence Detail 454 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000006526 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
  • EC
  • InterPro Domains
    IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
    IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site
    IPR000089 Biotin/lipoyl attachment
    IPR023213 Chloramphenicol acetyltransferase-like domain superfamily
    IPR006255 Dihydrolipoamide succinyltransferase
    IPR011053 Single hybrid motif
Molecular
Reagents
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  • All nucleic 266
    cDNA 266

    Microarray probesets 8
Other
Accession IDs
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MGI:1921476, MGI:2443879
References
more
  • Summaries
    All 48
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:263469 Malty RH, et al., A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-kappaB Signaling. Cell Syst. 2017 Dec 27;5(6):564-577.e12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory