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Sp2
Gene Detail
Symbol

Name
ID
Sp2
Sp2 transcription factor
MGI:1926162
Feature Type
protein coding gene
Genetic Map
Chromosome 11
60.17 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:96953341-96982959 bp, - strand
From VEGA annotation of GRCm38

  29619 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2340  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SP2
Protein SuperFamily: transcription factor, Sp1/Sp2/Sp3/Sp4 types
Gene Tree: Sp2

Human
homologs
SP2, Sp2 transcription factor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6668
neXtProt AC: NX_Q02086

Human Chr (Location): 17q21.32; chr17:47896054-47932271 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(200) : Gene trapped(192) Targeted(8)
Genomic Mutations involving Sp2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
No homozygous null mice survived beyond E10.5, with decrease embryo size and embryonic growth retardation starting at E7.5.
 
Phenotype Images(2)
Interactions
Sp2 interacts with 259 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cardiovascular system development, embryonic organ development, ...
Component nucleoplasm, nucleus
Function DNA binding, histone deacetylase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (53)    Tissues (53)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 45
RT-PCR 8
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sp2 ; ZFIN sp2    NEW 
Molecular
reagents
All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000001858 (Evidence)
Ensembl Gene Model ENSMUSG00000018678 (Evidence)
Entrez Gene 78912 (Evidence)
DFCI TC1579119
DoTS DT.522191, DT.110519685, DT.94305463, DT.97413127
NIA Mouse Gene Index U033330
Consensus CDS Project CCDS36291.1
International Mouse Phenotyping Consortium Status Sp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001858 VEGA Gene Model | MGI Sequence Detail 29619 C57BL/6J ±  kb
transcript OTTMUST00000003769 VEGA | MGI Sequence Detail 2907 Not Applicable 
polypeptide OTTMUSP00000001815 VEGA | MGI Sequence Detail 607 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(12) UniProt(6)
Polymorphisms
SNPs within 2kb(217 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000015440 transcription factor Sp2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194076 Liang H, et al., Neural development is dependent on the function of specificity protein 2 in cell cycle progression. Development. 2013 Feb 1;140(3):552-61
All references(47)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory