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Sp2
Gene Detail
 Symbol
Name
ID
Sp2
Sp2 transcription factor
MGI:1926162
Feature Type protein coding gene
Genetic Map
Chromosome 11
60.17 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:96953341-96982959 bp, - strand
From VEGA annotation of GRCm38

  29619 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2340  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: transcription factor, Sp1/Sp2/Sp3/Sp4 types
Gene Tree: Sp2

Human
homologs
Human Homolog SP2, Sp2 transcription factor
NCBI Gene ID 6668
neXtProt AC  NX_Q02086
Human Chr (Location)  17q21.32; chr17:47896150-47932271 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(199) : Gene trapped(192) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
No homozygous null mice survived beyond E10.5, with decrease embryo size and embryonic growth retardation starting at E7.5.
 
Interactions
Sp2 interacts with 259 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cardiovascular system development, embryonic organ development, ...
Component nucleus
Function DNA binding, histone deacetylase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (53)    Tissues (53)    Images (5)
Theiler Stages: 2, 3, 4, 5, 16, 17, 21, 23, 28
Assay TypeResults
RNA in situ 45
RT-PCR 8
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000001858 (Evidence)
Ensembl Gene ModelENSMUSG00000018678 (Evidence)
Entrez Gene78912 (Evidence)
DFCITC1579119
DoTSDT.110519685, DT.522191, DT.94305463, DT.97413127
NIA Mouse Gene IndexU033330
Consensus CDS ProjectCCDS36291.1
International Mouse Knockout Project StatusSp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001858 VEGA Gene Model | MGI Sequence Detail 29619 C57BL/6J ±  kb
transcript OTTMUST00000003769 VEGA | MGI Sequence Detail 2907 Not Applicable 
polypeptide OTTMUSP00000001815 VEGA | MGI Sequence Detail 607 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(12) UniProt(6)
Polymorphisms SNPs within 2kb(217 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000015440 transcription factor Sp2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194076 Liang H, et al., Neural development is dependent on the function of specificity protein 2 in cell cycle progression. Development. 2013 Feb 1;140(3):552-61
All references(48)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory