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Igsf3 Gene Detail
Summary
  • Symbol
    Igsf3
  • Name
    immunoglobulin superfamily, member 3
  • Synonyms
    1700016K10Rik, 2810035F16Rik, 4833439O17Rik, mKIAA0466
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926158
    NCBI Gene: 78908
Location & Maps
more
  • Sequence Map
    Chr3:101377083-101463059 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      85977 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 44.30 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    IGSF3, immunoglobulin superfamily member 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IGSF3, immunoglobulin superfamily member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EWI-3, LCDD, V8
  • Links
    NCBI Gene ID: 3321
    neXtProt AC: NX_O75054

  • Chr Location
    1p13; chr1:116574398-116667755 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1182
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: IGSF3
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human IGSF3 associations

Human Disease Mouse Models
       Lacrimal Duct Defect; LCDD   OMIM: 149700
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    1
  • Gene trapped
    20
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Igsf3
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052209 VEGA Gene Model | MGI Sequence Detail 85977 C57BL/6J ±  kb
transcript OTTMUST00000131172 VEGA | MGI Sequence Detail 3876 Not Applicable  
polypeptide OTTMUSP00000070201 VEGA | MGI Sequence Detail 1214 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    685 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000031371 immunoglobulin superfamily member 3
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR013106 Immunoglobulin V-set domain
Molecular
Reagents
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  • All nucleic 10
    cDNA 10

    Microarray probesets 3
Other
Accession IDs
less
MGI:1919956, MGI:1922800
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:229257 Gu Z, et al., Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory