About   Help   FAQ
Aacs Gene Detail
Summary
  • Symbol
    Aacs
  • Name
    acetoacetyl-CoA synthetase
  • Synonyms
    2210408B16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926144
    NCBI Gene: 78894
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:125475873-125517403 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 64.24 cM, cytoband F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    337 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926144
protein coding gene Chr5:125475814-125517410 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030113
protein coding gene Chr5:129331645-129377649 (+)
A/J MGP_AJ_G0030079
protein coding gene Chr5:123909013-123950474 (+)
AKR/J MGP_AKRJ_G0030014
protein coding gene Chr5:127928453-127980119 (+)
BALB/cJ MGP_BALBcJ_G0030090
protein coding gene Chr5:125242715-125285036 (+)
C3H/HeJ MGP_C3HHeJ_G0029807
protein coding gene Chr5:128535295-128581659 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030543
protein coding gene Chr5:134326270-134379231 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027768
protein coding gene Chr5:118444282-118484369 (+)
CAST/EiJ MGP_CASTEiJ_G0029216
protein coding gene Chr5:127677692-127725818 (+)
CBA/J MGP_CBAJ_G0029777
protein coding gene Chr5:139599140-139653034 (+)
DBA/2J MGP_DBA2J_G0029927
protein coding gene Chr5:123925230-123967799 (+)
FVB/NJ MGP_FVBNJ_G0029883
protein coding gene Chr5:123004650-123048278 (+)
LP/J MGP_LPJ_G0030016
protein coding gene Chr5:129849912-129892370 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029914
protein coding gene Chr5:143107598-143157305 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030584
protein coding gene Chr5:127547252-127591403 (+)
PWK/PhJ MGP_PWKPhJ_G0028930
protein coding gene Chr5:122767393-122807370 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028767
protein coding gene Chr5:125185100-125231940 (+)
WSB/EiJ MGP_WSBEiJ_G0029290
protein coding gene Chr5:128248517-128292787 (+)



Homology
more
  • Human Ortholog
    AACS, acetoacetyl-CoA synthetase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AACS, acetoacetyl-CoA synthetase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACSF1, SUR-5
  • Links
    NCBI Gene ID: 65985
    neXtProt AC: NX_Q86V21
    UniProt: Q86V21

  • Chr Location
    12q24.31; chr12:125065367-125143333 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11322
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AACS
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 78894 NCBI Gene Model | MGI Sequence Detail 41531 C57BL/6J ±  kb
transcript NM_030210 RefSeq | MGI Sequence Detail 3175 C57BL/6  
polypeptide Q9D2R0 UniProt | EBI | MGI Sequence Detail 672 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 4
References
more
  • Summaries
    All 33
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:233680 Hasegawa S, et al., Site-specific cleavage of acetoacetyl-CoA synthetase by legumain. FEBS Lett. 2016 Jun;590(11):1592-601

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/04/2018
MGI 6.13
The Jackson Laboratory