Pdk1
Gene Detail

Symbol Name ID

Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 MGI:1926119

Synonyms

D530020C15Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 2

42.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:71873224-71903858 bp, + strand From VEGA annotation of GRCm38   30635 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20576  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: branched-chain alpha-keto acid dehydrogenase kinase
Gene Tree: Pdk1

Human homologs

Human Homolog		PDK1, pyruvate dehydrogenase kinase, isozyme 1
NCBI Gene ID		5163
neXtProt AC		NX_Q15118
Human Chr (Location)		2q31.1; chr2:173420779-173463862 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(24) : Targeted(3) Gene trapped(20) Chemically induced(1)
Human Diseases Modeled Using Mouse Pdk1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(10)

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	carbohydrate metabolic process, cell proliferation, ...
Component	mitochondrion, plasma membrane, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (198)    Tissues (116)    Images (35)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	198

cDNA source data(140)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(141) cDNA(140) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000013264 (Evidence)
Ensembl Gene Model	ENSMUSG00000006494 (Evidence)
Entrez Gene	228026 (Evidence)
UniGene	34411
DFCI	TC1574312, TC1589408, TC1605204, TC1616989, TC1650716, TC1663024
DoTS	DT.101715670, DT.40136037, DT.493169, DT.55212099, DT.97353072
NIA Mouse Gene Index	U042315
EC	2.7.11.2
Consensus CDS Project	CCDS16119.1
International Mouse Knockout Project Status	Pdk1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000013264	VEGA Gene Model | MGI Sequence Detail	30635	C57BL/6J
transcript	OTTMUST00000032057	VEGA | MGI Sequence Detail	5185	Not Applicable
polypeptide	OTTMUSP00000014262	VEGA | MGI Sequence Detail	434	Not Applicable

All sequences(54) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(209 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003594	ATPase-like, ATP-binding domain
InterPro	IPR018955	Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
InterPro	IPR005467	Signal transduction histidine kinase, core
Protein Ontology	PR:000012504	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:172411 Dunford EC, et al., PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation. Am J Physiol Regul Integr Comp Physiol. 2011 Jun;300(6):R1487-93
All references(48)