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Pdk1
Gene Detail
Symbol

Name
ID
Pdk1
pyruvate dehydrogenase kinase, isoenzyme 1
MGI:1926119
Synonyms
D530020C15Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
42.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:71873224-71903858 bp, + strand
From VEGA annotation of GRCm38

  30635 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134437  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PDK1
Protein SuperFamily: branched-chain alpha-keto acid dehydrogenase kinase
Gene Tree: Pdk1

Human
homologs
PDK1, pyruvate dehydrogenase kinase, isozyme 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5163
neXtProt AC: NX_Q15118

Human Chr (Location): 2q31.1; chr2:172555373-172670881 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(20) Targeted(8)
Genomic Mutations involving Pdk1 (5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Phenotype Images(1)
Interactions
Pdk1 interacts with 316 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (198)    Tissues (116)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 198
cDNA source data(142)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pdk1    NEW 
Molecular
reagents
All nucleic(143) cDNA(142) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000013264 (Evidence)
Ensembl Gene Model ENSMUSG00000006494 (Evidence)
Entrez Gene 228026 (Evidence)
UniGene 34411
DFCI TC1650716, TC1589408, TC1605204, TC1616989, TC1574312, TC1663024
DoTS DT.55212099, DT.40136037, DT.493169, DT.101715670, DT.97353072
NIA Mouse Gene Index U042315
EC 2.7.11.2
Consensus CDS Project CCDS16119.1
International Mouse Phenotyping Consortium Status Pdk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013264 VEGA Gene Model | MGI Sequence Detail 30635 C57BL/6J ±  kb
transcript OTTMUST00000032057 VEGA | MGI Sequence Detail 5185 Not Applicable 
polypeptide OTTMUSP00000014262 VEGA | MGI Sequence Detail 434 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(508 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
InterPro IPR003594 Histidine kinase-like ATPase, ATP-binding domain
InterPro IPR005467 Signal transduction histidine kinase, core
Protein Ontology PR:000012504 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:213805 Harris PC, et al., Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease. J Clin Invest. 2014 Jun 2;124(6):2315-24
All references(50)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory