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Pdk1
Gene Detail
 Symbol
Name
ID
Pdk1
pyruvate dehydrogenase kinase, isoenzyme 1
MGI:1926119
Synonyms D530020C15Rik
Feature Type protein coding gene
Genetic Map
Chromosome 2
42.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:71873224-71903858 bp, + strand
From VEGA annotation of GRCm38

  30635 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134437  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: branched-chain alpha-keto acid dehydrogenase kinase
Gene Tree: Pdk1

Human
homologs
Human Homolog PDK1, pyruvate dehydrogenase kinase, isozyme 1
NCBI Gene ID 5163
neXtProt AC  NX_Q15118
Human Chr (Location)  2q31.1; chr2:172555373-172625623 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(20) Targeted(7)
Genomic Mutations involving Pdk1 (4)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Pdk1 interacts with 316 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process carbohydrate metabolic process, cell proliferation, ...
Component intracellular, mitochondrial pyruvate dehydrogenase complex, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (198)    Tissues (116)    Images (35)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 198
cDNA source data(142)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(143) cDNA(142) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000013264 (Evidence)
Ensembl Gene ModelENSMUSG00000006494 (Evidence)
Entrez Gene228026 (Evidence)
UniGene34411
DFCITC1574312, TC1589408, TC1605204, TC1616989, TC1650716, TC1663024
DoTSDT.101715670, DT.40136037, DT.493169, DT.55212099, DT.97353072
NIA Mouse Gene IndexU042315
EC2.7.11.2
Consensus CDS ProjectCCDS16119.1
International Mouse Knockout Project StatusPdk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013264 VEGA Gene Model | MGI Sequence Detail 30635 C57BL/6J ±  kb
transcript OTTMUST00000032057 VEGA | MGI Sequence Detail 5185 Not Applicable 
polypeptide OTTMUSP00000014262 VEGA | MGI Sequence Detail 434 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(7) UniProt(3)
Polymorphisms SNPs within 2kb(508 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
InterPro IPR003594 Histidine kinase-like ATPase, ATP-binding domain
InterPro IPR005467 Signal transduction histidine kinase, core
Protein Ontology PR:000012504 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:196247 Hitosugi T, et al., Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. Mol Cell. 2011 Dec 23;44(6):864-77
All references(49)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory