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Prima1 Gene Detail
Summary
  • Symbol
    Prima1
  • Name
    proline rich membrane anchor 1
  • Synonyms
    B230212M13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926097
    NCBI Gene: 170952
  • Gene Overview
    MyGene.info: PRIMA1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:103196908-103242150 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 52.90 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    325 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926097
protein coding gene Chr12:103194453-103242721 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020044
protein coding gene Chr12:104873159-104918394 (-)
A/J MGP_AJ_G0020000
protein coding gene Chr12:100836284-100881519 (-)
AKR/J MGP_AKRJ_G0019976
protein coding gene Chr12:103678851-103724090 (-)
BALB/cJ MGP_BALBcJ_G0019986
protein coding gene Chr12:101191915-101237139 (-)
C3H/HeJ MGP_C3HHeJ_G0019788
protein coding gene Chr12:104170706-104215937 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020435
protein coding gene Chr12:108126369-108171613 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018048
protein coding gene Chr12:97876380-97923074 (-)
CAST/EiJ MGP_CASTEiJ_G0019334
protein coding gene Chr12:99024998-99070351 (-)
CBA/J MGP_CBAJ_G0019760
protein coding gene Chr12:112146576-112191862 (-)
DBA/2J MGP_DBA2J_G0019871
protein coding gene Chr12:100356998-100402234 (-)
FVB/NJ MGP_FVBNJ_G0019860
protein coding gene Chr12:99090364-99138514 (-)
LP/J MGP_LPJ_G0019947
protein coding gene Chr12:104713824-104763121 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019900
protein coding gene Chr12:115599017-115646940 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020464
protein coding gene Chr12:103217039-103263757 (-)
PWK/PhJ MGP_PWKPhJ_G0019097
protein coding gene Chr12:94918588-94964054 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018893
protein coding gene Chr12:97416530-97463964 (-)
WSB/EiJ MGP_WSBEiJ_G0019388
protein coding gene Chr12:104103837-104152183 (-)



Homology
more
  • Human Ortholog
    PRIMA1, proline rich membrane anchor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PRIMA1, proline rich membrane anchor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PRIMA
  • Links
    NCBI Gene ID: 145270
    neXtProt AC: NX_Q86XR5
    UniProt: Q86XR5

  • Chr Location
    14q32.12; chr14:93718298-93789029 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased sensitivity to organophosphorus AChE inhibitors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041669 Ensembl Gene Model | MGI Sequence Detail 45243 C57BL/6J ±  kb
transcript ENSMUST00000074416 Ensembl | MGI Sequence Detail 909 Not Applicable  
polypeptide ENSMUSP00000074017 Ensembl | MGI Sequence Detail 153 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 2
Other
Accession IDs
less
MGI:2145067
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:244526 Mohr F, et al., Dysfunctional Presynaptic M2 Receptors in the Presence of Chronically High Acetylcholine Levels: Data from the PRiMA Knockout Mouse. PLoS One. 2015;10(10):e0141136

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory