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Slc5a10 Gene Detail
Summary
  • Symbol
    Slc5a10
  • Name
    solute carrier family 5 (sodium/glucose cotransporter), member 10
  • Synonyms
    C330021F16Rik, SGLT5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926089
    NCBI Gene: 109342
Location & Maps
more
  • Sequence Map
    Chr11:61672781-61720826 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      48046 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.96 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SLC5A10, solute carrier family 5 member 10
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC5A10, solute carrier family 5 member 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SGLT5, SGLT-5
  • Links
    NCBI Gene ID: 125206
    neXtProt AC: NX_A0PJK1

  • Chr Location
    17p11.2; chr17:18950676-19020691 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    1 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    4
  • Genomic Mutations
    1 involving Slc5a10
  • Incidental Mutations
    APF
Mice homozygous for a targeted allele exhibit impaired fructose reabsorption in the kidneys and exacerbated hepatic steatosis induced by fructose.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Other Mouse Links
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005841 VEGA Gene Model | MGI Sequence Detail 48046 C57BL/6J ±  kb
transcript OTTMUST00000012994 VEGA | MGI Sequence Detail 2261 Not Applicable  
polypeptide OTTMUSP00000006041 VEGA | MGI Sequence Detail 596 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    442 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015166 sodium/glucose cotransporter 5
  • InterPro Domains
    IPR001734 Sodium/solute symporter
    IPR018212 Sodium/solute symporter, conserved site
Molecular
Reagents
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  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 28
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:199406 Fukuzawa T, et al., SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose. PLoS One. 2013;8(2):e56681

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory