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Gins3 Gene Detail
Summary
  • Symbol
    Gins3
  • Name
    GINS complex subunit 3
  • Synonyms
    2700085M18Rik, Psf3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926083
    NCBI Gene: 78833
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:96360187-96371687 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 47.12 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    413 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926083
 protein coding gene Chr8:96360081-96371688 (+)
129S1/SvImJ ENSMUSG00200014446
 protein coding gene Chr8:90722208-90733828 (+)
A/J ENSMUSG00195003729
 protein coding gene Chr8:91057721-91069315 (+)
AKR/J ENSMUSG00220010820
 protein coding gene Chr8:91094567-91106161 (+)
BALB/cJ ENSMUSG00180003732
 protein coding gene Chr8:90959132-90970753 (+)
C3H/HeJ ENSMUSG00175002556
 protein coding gene Chr8:90999061-91010629 (+)
C57BL/6NJ ENSMUSG00215001219
 protein coding gene Chr8:90632321-90643931 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031427
 protein coding gene Chr8:87114604-87125598 (+)
CAST/EiJ ENSTCUG00005017030
 protein coding gene Chr8:90457735-90469342 (+)
CBA/J ENSMUSG00210014811
 protein coding gene Chr8:90934506-90946076 (+)
DBA/2J ENSMUSG00185021862
 protein coding gene Chr8:97043373-97054941 (+)
FVB/NJ ENSMUSG00205012558
 protein coding gene Chr8:90046576-90058194 (+)
JF1/MsJ ENSUMUG00000038404
 protein coding gene Chr8:99413471-99425090 (+)
LP/J ENSMUSG00230005776
 protein coding gene Chr8:100707225-100718834 (+)
NOD/ShiLtJ ENSMUSG00190011698
 protein coding gene Chr8:91063294-91074867 (+)
NZO/HlLtJ ENSMUSG00225009422
 protein coding gene Chr8:104112150-104123768 (+)
PWK/PhJ ENSLUMG00010038940
 protein coding gene Chr8:90786971-90798299 (+)
SPRET/EiJ ENSMSPG00010005581
 protein coding gene Chr8:92809659-92820180 (+)
WSB/EiJ ENSIUOG00005005400
 protein coding gene Chr8:91771677-91783249 (+)



Homology
more
  • Human Ortholog
    GINS3, GINS complex subunit 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GINS3, GINS complex subunit 3
  • Synonyms
    MGORS9, PSF3
  • Links
    NCBI Gene ID: 64785
    UniProt: Q9BRX5

  • Chr Location
    16q21; chr16:58295080-58406147 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous deletion is embryonic lethal. Homozygosity for a hypomorphic point mutation affects DNA replication and cellular senescence and leads to pre-weaning lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    24
  • GO References
    9
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    606
  • Tissues
    5
  • cDNA Data
    26
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 78833 NCBI Gene Model | MGI Sequence Detail 11501 C57BL/6J ±  kb
transcript NM_030198 RefSeq | MGI Sequence Detail 2412 C57BL/6  
polypeptide Q9CY94 UniProt | EBI | MGI Sequence Detail 216 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007984 DNA replication complex GINS protein PSF3
    (term hierarchy)
  • InterPro Domains
    IPR055221 DNA replication complex GINS protein PSF3, N-terminal domain
    IPR010492 GINS complex, subunit Psf3
    IPR038437 GINS complex, subunit Psf3 superfamily
    IPR036224 GINS, helical bundle-like domain superfamily
    IPR021151 GINS subunit, domain A
Molecular
Reagents
less
  • All nucleic 27
    cDNA 26
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142596
References
more
  • Summaries
    All 41
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory