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Rhot1 Gene Detail
Summary
  • Symbol
    Rhot1
  • Name
    ras homolog family member T1
  • Synonyms
    2210403N23Rik, Arht1, C430039G08Rik, FLJ11040, Miro1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926078
    NCBI Gene: 59040
  • Gene Overview
    MyGene.info: RHOT1
Location & Maps
more
  • Sequence Map
    Chr11:80209019-80267486 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      58468 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 47.62 cM, cytoband B5
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    RHOT1, ras homolog family member T1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    RHOT1, ras homolog family member T1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARHT1, MIRO1, MIRO-1
  • Links
    NCBI Gene ID: 55288
    neXtProt AC: NX_Q8IXI2
    UniProt: Q8IXI2

  • Chr Location
    17q11.2; chr17:32142454-32253374 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Rhot1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 4 alleles in 4 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die neonatally exhibiting cyanosis, respiratory failure, loss of brainstem cranial motor neurons, decreased cervical motor neuron number and phrenic nerve branching, and alterations in retrograde mitochondrial transport and run length in cortical axons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000219 VEGA Gene Model | MGI Sequence Detail 58468 C57BL/6J ±  kb
transcript OTTMUST00000000643 VEGA | MGI Sequence Detail 3297 Not Applicable  
polypeptide OTTMUSP00000000282 VEGA | MGI Sequence Detail 704 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    176 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    cDNA 27

    Microarray probesets 6
Other
Accession IDs
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MGI:1891738, MGI:1924850, MGI:2144011, MGI:2144268
References
more
  • Summaries
    All 52
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 6
    Phenotypes 18
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:240500 Lopez-Domenech G, et al., Loss of Dendritic Complexity Precedes Neurodegeneration in a Mouse Model with Disrupted Mitochondrial Distribution in Mature Dendrites. Cell Rep. 2016 Oct 04;17(2):317-327

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory