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Rhot1
Gene Detail
 Symbol
Name
ID
Rhot1
ras homolog gene family, member T1
MGI:1926078
Synonyms 2210403N23Rik, Arht1, C430039G08Rik, FLJ11040, Miro1
Feature Type protein coding gene
Genetic Map
Chromosome 11
47.62 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:80209019-80267486 bp, + strand
From VEGA annotation of GRCm38

  58468 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56803  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: mitochondrial Rho GTPase
Gene Tree: Rhot1

Human
homologs
Human Homolog RHOT1, ras homolog family member T1
NCBI Gene ID 55288
neXtProt AC  NX_Q8IXI2
Human Synonyms  ARHT1, MIRO1, MIRO-1
Human Chr (Location)  17q11.2; chr17:32142454-32253374 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(77) : Gene trapped(75) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Rhot1 interacts with 340 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cellular homeostasis, mitochondrial outer membrane permeabilization, ...
Component integral component of membrane, integral component of mitochondrial outer membrane, ...
Function calcium ion binding, GTPase activity, ...
External Resources: FuncBase
Expression
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) cDNA(27)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000000219 (Evidence)
Ensembl Gene ModelENSMUSG00000017686 (Evidence)
Entrez Gene59040 (Evidence)
DFCITC1573005, TC1591349, TC1598158, TC1607121, TC1608669, TC1611797, TC1619324, TC1624081, TC1665061
DoTSDT.101200697, DT.101737492, DT.110542869, DT.110542880, DT.492212, DT.91386244, DT.91592836, DT.94230691, DT.94230716, DT.97343317, DT.99849773
NIA Mouse Gene IndexU013050
EC3.6.5.-
Consensus CDS ProjectCCDS25130.1, CCDS48861.1, CCDS48862.1
International Mouse Knockout Project StatusRhot1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000219 VEGA Gene Model | MGI Sequence Detail 58468 C57BL/6J ±  kb
transcript OTTMUST00000000643 VEGA | MGI Sequence Detail 3297 Not Applicable 
polypeptide OTTMUSP00000000282 VEGA | MGI Sequence Detail 704 Not Applicable 

For the selected sequences
All sequences(111) RefSeq(21) UniProt(3)
Polymorphisms SNPs within 2kb(176 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR013566 EF hand associated, type-1
InterPro IPR013567 EF hand associated, type-2
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR020860 MIRO
InterPro IPR013684 Mitochondrial Rho-like
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR021181 Small GTPase superfamily, mitochondrial rho type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013985 mitochondrial Rho GTPase 1
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(46)
Other
accession IDs
MGI:1891738, MGI:1924850, MGI:2144011, MGI:2144268

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory