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Rhot1 Gene Detail
Summary
  • Symbol
    Rhot1
  • Name
    ras homolog family member T1
  • Synonyms
    2210403N23Rik, Arht1, C430039G08Rik, FLJ11040, Miro1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926078
    NCBI Gene: 59040
  • Gene Overview
    MyGene.info: RHOT1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:80209032-80267907 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 47.62 cM, cytoband B5
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    184 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926078
protein coding gene Chr11:80209019-80267907 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018809
protein coding gene Chr11:81359922-81420042 (+)
A/J MGP_AJ_G0018776
protein coding gene Chr11:78235405-78296299 (+)
AKR/J MGP_AKRJ_G0018746
protein coding gene Chr11:80583254-80643182 (+)
BALB/cJ MGP_BALBcJ_G0018749
protein coding gene Chr11:78620012-78682301 (+)
C3H/HeJ MGP_C3HHeJ_G0018563
protein coding gene Chr11:80629267-80691015 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019201
protein coding gene Chr11:83855090-83914546 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016835
protein coding gene Chr11:75165941-75229862 (+)
CAST/EiJ MGP_CASTEiJ_G0018118
protein coding gene Chr11:81117295-81181538 (+)
CBA/J MGP_CBAJ_G0018534
protein coding gene Chr11:87508803-87572514 (+)
DBA/2J MGP_DBA2J_G0018642
protein coding gene Chr11:77790490-77850581 (+)
FVB/NJ MGP_FVBNJ_G0018631
protein coding gene Chr11:77356917-77415679 (+)
LP/J MGP_LPJ_G0018712
protein coding gene Chr11:81875552-81937089 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018658
protein coding gene Chr11:87789550-87854965 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019241
protein coding gene Chr11:80837115-80897489 (+)
PWK/PhJ MGP_PWKPhJ_G0017888
protein coding gene Chr11:78593882-78657979 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017679
protein coding gene Chr11:80424895-80488272 (+)
WSB/EiJ MGP_WSBEiJ_G0018170
protein coding gene Chr11:80663475-80729181 (+)



Homology
more
  • Human Ortholog
    RHOT1, ras homolog family member T1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    RHOT1, ras homolog family member T1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARHT1, MIRO1, MIRO-1
  • Links
    NCBI Gene ID: 55288
    neXtProt AC: NX_Q8IXI2
    UniProt: Q8IXI2

  • Chr Location
    17q11.2; chr17:32142454-32253374 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Rhot1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 4 alleles in 4 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die neonatally exhibiting cyanosis, respiratory failure, loss of brainstem cranial motor neurons, decreased cervical motor neuron number and phrenic nerve branching, and alterations in retrograde mitochondrial transport and run length in cortical axons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 59040 NCBI Gene Model | MGI Sequence Detail 58876 C57BL/6J ±  kb
    transcript NM_001362868 RefSeq | MGI Sequence Detail 4360 C57BL/6  
    polypeptide Q8BG51 UniProt | EBI | MGI Sequence Detail 631 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 28

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1891738, MGI:1924850, MGI:2144011, MGI:2144268
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 8
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:240500 Lopez-Domenech G, et al., Loss of Dendritic Complexity Precedes Neurodegeneration in a Mouse Model with Disrupted Mitochondrial Distribution in Mature Dendrites. Cell Rep. 2016 Oct 04;17(2):317-327

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory