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Desi2 Gene Detail
Summary
  • Symbol
    Desi2
  • Name
    desumoylating isopeptidase 2
  • Synonyms
    5830417C01Rik, Fam152a, Pppde1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926075
    NCBI Gene: 78825
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:178187417-178252598 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 82.93 cM, cytoband H3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    90 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926075
protein coding gene Chr1:178187417-178257301 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0016830
protein coding gene Chr1:177019026-177092958 (+)
AKR/J MGP_AKRJ_G0016796
protein coding gene Chr1:182306867-182377019 (+)
BALB/cJ MGP_BALBcJ_G0016788
protein coding gene Chr1:177354750-177748264 (+)
C3H/HeJ MGP_C3HHeJ_G0016613
protein coding gene Chr1:183046220-183126327 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017252
protein coding gene Chr1:190226614-190537279 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014959
protein coding gene Chr1:168066388-168121225 (+)
CAST/EiJ MGP_CASTEiJ_G0016194
protein coding gene Chr1:182325828-182411753 (+)
CBA/J MGP_CBAJ_G0016587
protein coding gene Chr1:197228881-197606115 (+)
DBA/2J MGP_DBA2J_G0016693
protein coding gene Chr1:175898088-175967387 (+)
FVB/NJ MGP_FVBNJ_G0016689
protein coding gene Chr1:173980487-174047058 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0016720
protein coding gene Chr1:204414917-204805557 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017288
protein coding gene Chr1:181850335-182109002 (+)
PWK/PhJ MGP_PWKPhJ_G0015982
protein coding gene Chr1:175007405-175027614 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015758
protein coding gene Chr1:180736999-181049910 (+)
WSB/EiJ MGP_WSBEiJ_G0016257
protein coding gene Chr1:182249270-182323055 (+)



Homology
more
  • Human Ortholog
    DESI2, desumoylating isopeptidase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DESI2, desumoylating isopeptidase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C1orf121, CGI-146, DESI, DESI1, DeSI-2, FAM152A, PNAS-4, PPPDE1
  • Links
    NCBI Gene ID: 51029
    neXtProt AC: NX_Q9BSY9
    UniProt: Q9BSY9

  • Chr Location
    1q44; chr1:244653048-244709034 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56741
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DESI2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    2
  • Gene trapped
    7
  • Targeted
    4
  • Genomic Mutations
    2 involving Desi2
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for a knock-out mouse exhibit normal body size, body weight, brain size, brain weight and neuron apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 78825 NCBI Gene Model | MGI Sequence Detail 65182 C57BL/6J ±  kb
transcript NM_024282 RefSeq | MGI Sequence Detail 4214 C57BL/6  
polypeptide NP_077244 RefSeq | MGI Sequence Detail 194 C57BL/6  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 69
    cDNA 69

    Microarray probesets 5
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:61896 Lee YJ, et al., Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). FEBS Lett. 2000 Apr 28;472(2-3):230-4
  • Latest
    J:183741 Cai P, et al., PNAS4 knockout does not induce obviously neurocytes apoptosis and abnormal development in mice brain. Mol Biol Rep. 2012 Jan;39(1):621-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory