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Stxbp5 Gene Detail
Summary
  • Symbol
    Stxbp5
  • Name
    syntaxin binding protein 5 (tomosyn)
  • Synonyms
    0710001E20Rik, 4930565N16Rik, LGL3, mKIAA1006, tomosyn 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926058
    NCBI Gene: 78808
  • Gene Overview
    MyGene.info: STXBP5
Location & Maps
more
  • Sequence Map
    Chr10:9755547-9901079 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      145533 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 3.21 cM, cytoband A2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    STXBP5, syntaxin binding protein 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STXBP5, syntaxin binding protein 5
    Orthology source: HomoloGene
  • Synonyms
    LGL3, LLGL3, Nbla04300
  • Links
    NCBI Gene ID: 134957
    neXtProt AC: NX_Q5T5C0

  • Chr Location
    6q24.3; chr6:147204358-147390476 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 3 genetic backgrounds
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit some background sensitive prenatal lethality and increased synaptic transmission.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033369 VEGA Gene Model | MGI Sequence Detail 145533 C57BL/6J ±  kb
transcript OTTMUST00000083763 VEGA | MGI Sequence Detail 8825 Not Applicable  
polypeptide OTTMUSP00000045051 VEGA | MGI Sequence Detail 1152 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    940 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 65
    cDNA 65

    Microarray probesets 7
Other
Accession IDs
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MGI:1921351, MGI:2143879
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:217626 Ye S, et al., Platelet secretion and hemostasis require syntaxin-binding protein STXBP5. J Clin Invest. 2014 Oct;124(10):4517-28

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory