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Stxbp5
Gene Detail
 Symbol
Name
ID
Stxbp5
syntaxin binding protein 5 (tomosyn)
MGI:1926058
Synonyms 0710001E20Rik, 4930565N16Rik, LGL3, mKIAA1006, tomosyn 1
Feature Type protein coding gene
Genetic Map
Chromosome 10
3.21 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:9755547-9901079 bp, - strand
From VEGA annotation of GRCm38

  145533 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:16402  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: syntaxin binding protein 5
Gene Tree: Stxbp5

Human
homologs
Human Homolog STXBP5, syntaxin binding protein 5 (tomosyn)
NCBI Gene ID 134957
neXtProt AC  NX_Q5T5C0
Human Synonyms  LGL3, LLGL3, Nbla04300
Human Chr (Location)  6q24.3; chr6:147204358-147390476 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit some background sensitive prenatal lethality and increased synaptic transmission.
 
Interactions
Stxbp5 interacts with 483 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process axonogenesis, exocytosis, ...
Component acetylcholine-gated channel complex, cytoplasm, ...
Function protein binding, syntaxin-1 binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(65)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(65) cDNA(65)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000033369 (Evidence)
Ensembl Gene ModelENSMUSG00000019790 (Evidence)
Entrez Gene78808 (Evidence)
UniGene331751
DFCITC1582910, TC1598827, TC1599625, TC1604846, TC1612624, TC1617884
DoTSDT.101163957, DT.103565000, DT.110612410, DT.529437, DT.94204266, DT.94231457, DT.97365201
NIA Mouse Gene IndexU043865
Consensus CDS ProjectCCDS35837.2
International Mouse Knockout Project StatusStxbp5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033369 VEGA Gene Model | MGI Sequence Detail 145533 C57BL/6J ±  kb
transcript OTTMUST00000083763 VEGA | MGI Sequence Detail 8825 Not Applicable 
polypeptide OTTMUSP00000045051 VEGA | MGI Sequence Detail 1152 Not Applicable 

For the selected sequences
All sequences(92) RefSeq(20) UniProt(4)
Polymorphisms SNPs within 2kb(948 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000664 Lethal(2) giant larvae protein
InterPro IPR013577 Lethal giant larvae homologue 2
InterPro IPR013905 Lethal giant larvae (Lgl)-like, C-terminal
InterPro IPR001388 Synaptobrevin
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000015804 syntaxin-binding protein 5
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:171136 Williams AL, et al., Structural and functional analysis of tomosyn identifies domains important in exocytotic regulation. J Biol Chem. 2011 Apr 22;286(16):14542-53
All references(36)
Other
accession IDs
MGI:1921351, MGI:2143879

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory