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Usp54 Gene Detail
Summary
  • Symbol
    Usp54
  • Name
    ubiquitin specific peptidase 54
  • Synonyms
    4930429G18Rik, C030002J06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926037
    NCBI Gene: 78787
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:20598980-20691131 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 11.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1702 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926037
 protein coding gene Chr14:20598980-20694559 (-)
129S1/SvImJ ENSMUSG00200014743
 protein coding gene Chr14:12385220-12477300 (-)
A/J ENSMUSG00195019814
 protein coding gene Chr14:13471530-13563689 (-)
AKR/J ENSMUSG00220025482
 protein coding gene Chr14:12602047-12694232 (-)
BALB/cJ ENSMUSG00180038383
 protein coding gene Chr14:12566455-12658613 (-)
C3H/HeJ ENSMUSG00175020998
 protein coding gene Chr14:12627435-12719595 (-)
C57BL/6NJ ENSMUSG00215025701
 protein coding gene Chr14:12817042-12909213 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018992
 protein coding gene Chr14:13316266-13385491 (-)
CAST/EiJ ENSTCUG00005026876
 protein coding gene Chr14:12741989-12834627 (-)
CBA/J ENSMUSG00210026185
 protein coding gene Chr14:12858313-12950400 (-)
DBA/2J ENSMUSG00185037059
 protein coding gene Chr14:17143388-17235467 (-)
FVB/NJ ENSMUSG00205027802
 protein coding gene Chr14:12700325-12792413 (-)
JF1/MsJ ENSUMUG00000043082
 protein coding gene Chr14:24357956-24450846 (-)
LP/J ENSMUSG00230037383
 protein coding gene Chr14:24425172-24517257 (-)
NOD/ShiLtJ ENSMUSG00190036089
 protein coding gene Chr14:12857220-12949302 (-)
NZO/HlLtJ ENSMUSG00225034911
 protein coding gene Chr14:18653079-18751789 (-)
PWK/PhJ ENSLUMG00010020139
 protein coding gene Chr14:930113-1022630 (-)
SPRET/EiJ ENSMSPG00010029951
 protein coding gene Chr14:14481589-14541471 (-)
WSB/EiJ ENSIUOG00005031221
 protein coding gene Chr14:12674300-12766417 (-)



Homology
more
  • Human Ortholog
    USP54, ubiquitin specific peptidase 54
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP54, ubiquitin specific peptidase 54
  • Synonyms
    bA137L10.3, bA137L10.4, C10orf29
  • Links
    NCBI Gene ID: 159195
    UniProt: Q70EL1

  • Chr Location
    10q22.2; chr10:73497538-73626117 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    73
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034235 Ensembl Gene Model | MGI Sequence Detail 92152 C57BL/6J ±  kb
    transcript ENSMUST00000022356 Ensembl | MGI Sequence Detail 6580 Not Applicable  
    polypeptide ENSMUSP00000022356 Ensembl | MGI Sequence Detail 1588 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000017193 ubiquitin carboxyl-terminal hydrolase 54
      (term hierarchy)
    • EC
      3.4.19.12
    • InterPro Domains
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
      IPR052398 Ubiquitin carboxyl-terminal hydrolase 53/54
      IPR028889 Ubiquitin specific protease USP, catalytic domain
    • GlyGen
      Q8BL06 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 73
      cDNA 73

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2145598, MGI:2442602
    References
    more
    • Summaries
      All 40
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory