Zc3hav1 MGI Mouse Gene Detail - MGI:1926031 - zinc finger CCCH type, antiviral 1

Symbol

Zc3hav1
Name

zinc finger CCCH type, antiviral 1
Synonyms

1200014N16Rik, 2900058M19Rik, 9130009D18Rik, 9830115L13Rik, ZAP

Feature Type

protein coding gene
IDs

MGI:1926031
NCBI Gene: 78781
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr6:38282221-38331538 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 17.72 cM, cytoband B1
Mapping Data

1 experiment

SNPs within 2kb

1298 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926031	protein coding gene	Chr6:38282221-38332859 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030584	protein coding gene	Chr6:36598023-36655367 (-)
A/J	MGP_AJ_G0030557	protein coding gene	Chr6:35009669-35060329 (-)
AKR/J	MGP_AKRJ_G0030484	protein coding gene	Chr6:36122215-36178060 (-)
BALB/cJ	MGP_BALBcJ_G0030567	protein coding gene	Chr6:35201138-35254182 (-)
C3H/HeJ	MGP_C3HHeJ_G0030280	protein coding gene	Chr6:36129022-36187553 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031021	protein coding gene	Chr6:37513329-37568504 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028233	protein coding gene	Chr6:32929752-32977931 (-)
CAST/EiJ	MGP_CASTEiJ_G0029682	protein coding gene	Chr6:36020816-36078295 (-)
CBA/J	MGP_CBAJ_G0030258	protein coding gene	Chr6:38953852-39026168 (-)
DBA/2J	MGP_DBA2J_G0030402	protein coding gene	Chr6:34830423-34882541 (-)
FVB/NJ	MGP_FVBNJ_G0030356	protein coding gene	Chr6:34616366-34667262 (-)
LP/J	MGP_LPJ_G0030489	protein coding gene	Chr6:36645949-36698787 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030392	protein coding gene	Chr6:41319594-41381448 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031051	protein coding gene	Chr6:36054824-36109492 (-)
PWK/PhJ	MGP_PWKPhJ_G0029396	protein coding gene	Chr6:34477469-34529750 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029232	protein coding gene	Chr6:35775285-35832455 (-)
WSB/EiJ	MGP_WSBEiJ_G0029758	protein coding gene	Chr6:35990447-36048876 (-)

Human Ortholog

ZC3HAV1, zinc finger CCCH-type containing, antiviral 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZC3HAV1, zinc finger CCCH-type containing, antiviral 1
Synonyms

ARTD13, FLB6421, PARP13, ZAP, ZC3H2, ZC3HDC2
Links

HGNC:23721

NCBI Gene ID: 56829

UniProt: Q7Z2W4
Chr Location

7q34; chr7:139043515-139132122 (-) GRCh38

MGI Vertebrate Homology

Zc3hav1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZC3HAV1
Gene Tree

Zc3hav1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Gene trapped

3
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

44 strains or lines available

Mice homozygous for a knock-out allele exhibit reduced murine leukemia virus replication efficiency in mouse embryonic fibroblasts.

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All GO Annotations

55
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

745
Tissues

13
cDNA Data

19
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

60
RefSeq

8
UniProt

6
CCDS

CCDS20012.1, CCDS80522.1, CCDS85033.1

Ensembl

ENSMUSG00000029826 (Evidence)
NCBI Gene

78781

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029826	Ensembl Gene Model \| MGI Sequence Detail	49318	C57BL/6J	± kb
transcript	ENSMUST00000114900	Ensembl \| MGI Sequence Detail	4944	Not Applicable
polypeptide	ENSMUSP00000110550	Ensembl \| MGI Sequence Detail	996	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000017601 zinc finger CCCH-type antiviral protein 1

(term hierarchy)
PDB

6L1W, 7SZ2, 7SZ3
InterPro Domains

IPR051712 Mono-ADP-ribosyltransferase and antiviral protein

IPR012317 Poly(ADP-ribose) polymerase, catalytic domain

IPR036388 Winged helix-like DNA-binding domain superfamily

IPR004170 WWE domain

IPR037197 WWE domain superfamily

IPR041360 ZAP, helix turn helix N-terminal domain

IPR040954 ZAP, zinc finger

IPR000571 Zinc finger, CCCH-type

IPR026693 Zinc finger CCCH-type antiviral protein 1-like
GlyGen

Q3UPF5 1 site, 1 O-linked glycan (1 site)

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All nucleic 20

cDNA 19

Primer pair 1

Microarray probesets 6

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MGI:1920298, MGI:1921567, MGI:2441762

Summaries

All 43

Developmental Gene Expression 4

Gene Ontology 11

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:348655 Goncalves-Carneiro D, et al., Rational attenuation of RNA viruses with zinc finger antiviral protein. Nat Microbiol. 2022 Oct;7(10):1558-1567

TSS for Zc3hav1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr60411	Chr6:38332468-38332486 (-)	-939 bp
Tssr60410	Chr6:38332455-38332466 (-)	-923 bp
Tssr60409	Chr6:38331536-38331539 (-)	0 bp
Tssr60408	Chr6:38331482-38331500 (-)	47 bp
Tssr60407	Chr6:38331178-38331227 (-)	335 bp
Tssr60406	Chr6:38331166-38331175 (-)	367 bp
Tssr60405	Chr6:38331037-38331072 (-)	483 bp
Tssr60404	Chr6:38327576-38327582 (-)	3,959 bp
Tssr60403	Chr6:38322861-38322873 (-)	8,671 bp
Tssr60402	Chr6:38320001-38320009 (-)	11,533 bp
Tssr60401	Chr6:38318790-38318804 (-)	12,741 bp
Tssr60400	Chr6:38318135-38318140 (-)	13,400 bp
Tssr60399	Chr6:38296680-38296693 (-)	34,851 bp
Tssr60398	Chr6:38288621-38288632 (-)	42,911 bp
Tssr60397	Chr6:38285199-38285202 (-)	46,337 bp
Tssr60396	Chr6:38284187-38284246 (-)	47,321 bp
Tssr60395	Chr6:38283684-38283703 (-)	47,844 bp
Tssr60394	Chr6:38283620-38283627 (-)	47,914 bp
Tssr60393	Chr6:38283238-38283240 (-)	48,299 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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