About   Help   FAQ
Zc3hav1 Gene Detail
Summary
  • Symbol
    Zc3hav1
  • Name
    zinc finger CCCH type, antiviral 1
  • Synonyms
    1200014N16Rik, 2900058M19Rik, 9130009D18Rik, 9830115L13Rik, ZAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926031
    NCBI Gene: 78781
  • Gene Overview
    MyGene.info: ZC3HAV1
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:38305286-38354603 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 17.72 cM, cytoband B1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    210 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926031
 protein coding gene Chr6:38305286-38355571 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030584
 protein coding gene Chr6:36598023-36655367 (-)
A/J MGP_AJ_G0030557
 protein coding gene Chr6:35009669-35060329 (-)
AKR/J MGP_AKRJ_G0030484
 protein coding gene Chr6:36122215-36178060 (-)
BALB/cJ MGP_BALBcJ_G0030567
 protein coding gene Chr6:35201138-35254182 (-)
C3H/HeJ MGP_C3HHeJ_G0030280
 protein coding gene Chr6:36129022-36187553 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031021
 protein coding gene Chr6:37513329-37568504 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028233
 protein coding gene Chr6:32929752-32977931 (-)
CAST/EiJ MGP_CASTEiJ_G0029682
 protein coding gene Chr6:36020816-36078295 (-)
CBA/J MGP_CBAJ_G0030258
 protein coding gene Chr6:38953852-39026168 (-)
DBA/2J MGP_DBA2J_G0030402
 protein coding gene Chr6:34830423-34882541 (-)
FVB/NJ MGP_FVBNJ_G0030356
 protein coding gene Chr6:34616366-34667262 (-)
LP/J MGP_LPJ_G0030489
 protein coding gene Chr6:36645949-36698787 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030392
 protein coding gene Chr6:41319594-41381448 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031051
 protein coding gene Chr6:36054824-36109492 (-)
PWK/PhJ MGP_PWKPhJ_G0029396
 protein coding gene Chr6:34477469-34529750 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029232
 protein coding gene Chr6:35775285-35832455 (-)
WSB/EiJ MGP_WSBEiJ_G0029758
 protein coding gene Chr6:35990447-36048876 (-)



Homology
more
  • Human Ortholog
    ZC3HAV1, zinc finger CCCH-type containing, antiviral 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ZC3HAV1, zinc finger CCCH-type containing, antiviral 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARTD13, FLB6421, PARP13, ZAP, ZC3H2, ZC3HDC2
  • Links
    NCBI Gene ID: 56829
    neXtProt AC: NX_Q7Z2W4
    UniProt: Q7Z2W4

  • Chr Location
    7q34; chr7:139043519-139109720 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced murine leukemia virus replication efficiency in mouse embryonic fibroblasts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    36
  • Tissues
    10
  • cDNA Data
    19
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029826 Ensembl Gene Model | MGI Sequence Detail 49318 C57BL/6J ±  kb
transcript ENSMUST00000114900 Ensembl | MGI Sequence Detail 4944 Not Applicable  
polypeptide ENSMUSP00000110550 Ensembl | MGI Sequence Detail 996 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 19
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1920298, MGI:1921567, MGI:2441762
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:230911 Kozaki T, et al., Role of zinc-finger anti-viral protein in host defense against Sindbis virus. Int Immunol. 2015 Jul;27(7):357-64
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
01/08/2019
MGI 6.13 		The Jackson Laboratory