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Rictor Gene Detail
Summary
  • Symbol
    Rictor
  • Name
    RPTOR independent companion of MTOR, complex 2
  • Synonyms
    4921505C17Rik, 6030405M08Rik, D530039E11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926007
    NCBI Gene: 78757
  • Gene Overview
    MyGene.info: RICTOR
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:6708381-6800398 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      92018 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 3.25 cM, cytoband A1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RICTOR, RPTOR independent companion of MTOR complex 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RICTOR, RPTOR independent companion of MTOR complex 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AVO3, hAVO3, PIA
  • Links
    NCBI Gene ID: 253260
    neXtProt AC: NX_Q6R327
    UniProt: Q6R327

  • Chr Location
    5p13.1; chr5:38937920-39074421 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 34317
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RICTOR
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    53 phenotypes from 8 alleles in 10 genetic backgrounds
    22 phenotypes from multigenic genotypes
    3 images
    87 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality during organogenesis associated with abnormal placental morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050310 Ensembl Gene Model | MGI Sequence Detail 92018 C57BL/6J ±  kb
transcript ENSMUST00000061656 Ensembl | MGI Sequence Detail 9311 Not Applicable  
polypeptide ENSMUSP00000051809 Ensembl | MGI Sequence Detail 1708 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    436 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000013999 rapamycin-insensitive companion of mTOR
  • InterPro Domains
    IPR011989 Armadillo-like helical
    IPR016024 Armadillo-type fold
    IPR028268 Pianissimo family
    IPR029453 Rapamycin-insensitive companion of mTOR, domain 4
    IPR029452 Rapamycin-insensitive companion of mTOR, domain 5
    IPR029451 Rapamycin-insensitive companion of mTOR, middle domain
    IPR028267 Rapamycin-insensitive companion of mTOR, N-terminal domain
    IPR029259 Rapamycin-insensitive companion of mTOR, phosphorylation-site
Molecular
Reagents
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  • All nucleic 18
    cDNA 18

    Microarray probesets 9
Other
Accession IDs
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MGI:1924409, MGI:1925833, MGI:2146218
References
more
  • Summaries
    All 150
    Developmental Gene Expression 11
    Gene Ontology 17
    Phenotypes 87
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:246561 Sklarz T, et al., mTORC2 regulates multiple aspects of NKT-cell development and function. Eur J Immunol. 2017 Mar;47(3):516-526

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory