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Cpxm2 Gene Detail
Summary
  • Symbol
    Cpxm2
  • Name
    carboxypeptidase X 2 (M14 family)
  • Synonyms
    4632435C11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926006
    NCBI Gene: 55987
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:132032687-132154739 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 75.60 cM, cytoband F4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    644 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926006
protein coding gene Chr7:132032687-132154763 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033110
protein coding gene Chr7:136722235-136838641 (-)
A/J MGP_AJ_G0033092
protein coding gene Chr7:132957619-133071640 (-)
AKR/J MGP_AKRJ_G0033024
protein coding gene Chr7:136498584-136612202 (-)
BALB/cJ MGP_BALBcJ_G0033093
protein coding gene Chr7:132642300-132752021 (-)
C3H/HeJ MGP_C3HHeJ_G0032807
protein coding gene Chr7:136339728-136453001 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033604
protein coding gene Chr7:141924538-142038474 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030575
protein coding gene Chr7:134222924-134338963 (-)
CAST/EiJ MGP_CASTEiJ_G0032137
protein coding gene Chr7:128210897-128320499 (-)
CBA/J MGP_CBAJ_G0032780
protein coding gene Chr7:146754987-146871613 (-)
DBA/2J MGP_DBA2J_G0032932
protein coding gene Chr7:130972550-131083282 (-)
FVB/NJ MGP_FVBNJ_G0032885
protein coding gene Chr7:130798981-130909309 (-)
LP/J MGP_LPJ_G0033026
protein coding gene Chr7:138204523-138327792 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032917
protein coding gene Chr7:147718478-147830587 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033624
protein coding gene Chr7:135488998-135601939 (-)
PWK/PhJ MGP_PWKPhJ_G0031843
protein coding gene Chr7:123979785-124093172 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031689
protein coding gene Chr7:122275494-122389335 (-)
WSB/EiJ MGP_WSBEiJ_G0032248
protein coding gene Chr7:136392964-136505869 (-)



Homology
more
  • Human Ortholog
    CPXM2, carboxypeptidase X, M14 family member 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CPXM2, carboxypeptidase X, M14 family member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CPX2, UNQ676
  • Links
    NCBI Gene ID: 119587
    neXtProt AC: NX_Q8N436
    UniProt: Q8N436

  • Chr Location
    10q26.13; chr10:123745636-123944094 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 69259
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CPXM2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030862 Ensembl Gene Model | MGI Sequence Detail 122053 C57BL/6J ±  kb
transcript ENSMUST00000033149 Ensembl | MGI Sequence Detail 3498 Not Applicable  
polypeptide ENSMUSP00000033149 Ensembl | MGI Sequence Detail 764 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR034243 AEBP1/CPX, carboxypeptidase domain
    IPR008969 Carboxypeptidase-like, regulatory domain superfamily
    IPR000421 Coagulation factor 5/8 C-terminal domain
    IPR008979 Galactose-binding-like domain superfamily
    IPR000834 Peptidase M14, carboxypeptidase A
Molecular
Reagents
less
  • All nucleic 19
    cDNA 19

    Microarray probesets 5
References
more
  • Summaries
    All 30
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:50715 Xin X, et al., Identification of mouse CPX-2, a novel member of the metallocarboxypeptidase gene family: cDNA cloning, mRNA distribution, and protein expression and characterization. DNA Cell Biol. 1998 Oct;17(10):897-909
  • Latest
    J:197180 Buniello A, et al., Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness. PLoS One. 2013;8(2):e56274

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory