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Arhgef19 Gene Detail
Summary
  • Symbol
    Arhgef19
  • Name
    Rho guanine nucleotide exchange factor (GEF) 19
  • Synonyms
    6430573B13Rik, WGEF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925912
    NCBI Gene: 213649
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:141239499-141257564 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 73.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    176 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925912
protein coding gene Chr4:141239499-141257915 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029042
protein coding gene Chr4:144269939-144290357 (+)
A/J MGP_AJ_G0029001
protein coding gene Chr4:138006029-138023897 (+)
AKR/J MGP_AKRJ_G0028953
protein coding gene Chr4:141985955-142004024 (+)
BALB/cJ MGP_BALBcJ_G0029025
protein coding gene Chr4:138697227-138715286 (+)
C3H/HeJ MGP_C3HHeJ_G0028739
protein coding gene Chr4:142360858-142379449 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029466
protein coding gene Chr4:149313523-149331588 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026737
protein coding gene Chr4:130917730-130936295 (+)
CAST/EiJ MGP_CASTEiJ_G0028171
protein coding gene Chr4:140617948-140636796 (+)
CBA/J MGP_CBAJ_G0028703
protein coding gene Chr4:153632782-153651003 (+)
DBA/2J MGP_DBA2J_G0028853
protein coding gene Chr4:138397686-138416272 (+)
FVB/NJ MGP_FVBNJ_G0028820
protein coding gene Chr4:137503529-137524331 (+)
LP/J MGP_LPJ_G0028952
protein coding gene Chr4:144291225-144309286 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028846
protein coding gene Chr4:157469639-157489209 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029504
protein coding gene Chr4:142510458-142528499 (+)
PWK/PhJ MGP_PWKPhJ_G0027892
protein coding gene Chr4:135285257-135303899 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027717
protein coding gene Chr4:138329722-138347952 (+)
WSB/EiJ MGP_WSBEiJ_G0028249
protein coding gene Chr4:142795050-142815498 (+)



Homology
more
  • Human Ortholog
    ARHGEF19, Rho guanine nucleotide exchange factor 19
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ARHGEF19, Rho guanine nucleotide exchange factor 19
    Orthology source: HomoloGene, HGNC
  • Synonyms
    WGEF
  • Links
    NCBI Gene ID: 128272
    neXtProt AC: NX_Q8IW93
    UniProt: Q8IW93

  • Chr Location
    1p36.13; chr1:16197856-16212699 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028919 Ensembl Gene Model | MGI Sequence Detail 18066 C57BL/6J ±  kb
transcript ENSMUST00000006618 Ensembl | MGI Sequence Detail 3414 Not Applicable  
polypeptide ENSMUSP00000006618 Ensembl | MGI Sequence Detail 802 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    cDNA 30

    Microarray probesets 2
References
more
  • Summaries
    All 30
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:267222 Kimura-Yoshida C, et al., Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis. Nat Commun. 2018 Oct 3;9(1):4059

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory