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C1qtnf7 Gene Detail
Summary
  • Symbol
    C1qtnf7
  • Name
    C1q and tumor necrosis factor related protein 7
  • Synonyms
    5530401N20Rik, 8430425G24Rik, CTRP7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925911
    NCBI Gene: 109323
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:43515538-43618803 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 23.78 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1213 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925911
protein coding gene Chr5:43515402-43619126 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029522
protein coding gene Chr5:42143413-42245932 (+)
A/J MGP_AJ_G0029488
protein coding gene Chr5:40685565-40793572 (+)
AKR/J MGP_AKRJ_G0029438
protein coding gene Chr5:42133512-42238410 (+)
BALB/cJ MGP_BALBcJ_G0029499
protein coding gene Chr5:41159202-41265276 (+)
C3H/HeJ MGP_C3HHeJ_G0029222
protein coding gene Chr5:42103950-42207670 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029953
protein coding gene Chr5:44179588-44286097 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027192
protein coding gene Chr5:37936631-38037372 (+)
CAST/EiJ MGP_CASTEiJ_G0028630
protein coding gene Chr5:41216188-41327718 (+)
CBA/J MGP_CBAJ_G0029191
protein coding gene Chr5:45330190-45448482 (+)
DBA/2J MGP_DBA2J_G0029336
protein coding gene Chr5:40780203-40882911 (+)
FVB/NJ MGP_FVBNJ_G0029297
protein coding gene Chr5:40205504-40308205 (+)
LP/J MGP_LPJ_G0029422
protein coding gene Chr5:42582633-42696055 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029325
protein coding gene Chr5:46148791-46254385 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029986
protein coding gene Chr5:41620112-41727790 (+)
PWK/PhJ MGP_PWKPhJ_G0028354
protein coding gene Chr5:39901513-40007080 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028188
protein coding gene Chr5:41056092-41161039 (+)
WSB/EiJ MGP_WSBEiJ_G0028711
protein coding gene Chr5:41685004-41799109 (+)



Homology
more
  • Human Ortholog
    C1QTNF7, C1q and TNF related 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    C1QTNF7, C1q and TNF related 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CTRP7, ZACRP7
  • Links
    NCBI Gene ID: 114905
    neXtProt AC: NX_Q9BXJ2
    UniProt: Q9BXJ2

  • Chr Location
    4p15.32; chr4:15339818-15446169 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased weight, liver fibrosis, male-specific glucose serum levels and adipose inflammation with male-specific improved glucose tolerance when fed a high-fat diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061535 Ensembl Gene Model | MGI Sequence Detail 103266 C57BL/6J ±  kb
    transcript ENSMUST00000076939 Ensembl | MGI Sequence Detail 3879 Not Applicable  
    polypeptide ENSMUSP00000076206 Ensembl | MGI Sequence Detail 296 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR001073 C1q domain
      IPR008160 Collagen triple helix repeat
      IPR008983 Tumour necrosis factor-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1918691
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 2
      Phenotypes 24
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:244352 Petersen PS, et al., CTRP7 deletion attenuates obesity-linked glucose intolerance, adipose tissue inflammation, and hepatic stress. Am J Physiol Endocrinol Metab. 2017 Apr 01;312(4):E309-E325

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory