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Fhod3
Gene Detail
Symbol

Name
ID
Fhod3
formin homology 2 domain containing 3
MGI:1925847
Synonyms
A930009H06Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 18
13.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr18:24709445-25133500 bp, + strand
From Ensembl annotation of GRCm38

  424056 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:45323  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Fhod3

Human
homologs
Human Homolog FHOD3, formin homology 2 domain containing 3
NCBI Gene ID 80206
neXtProt AC  NX_Q2V2M9
Human Synonyms  FHOS2, Formactin2
Human Chr (Location)  18q12; chr18:36297696-36780059 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(22) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out reporter allele exhibit abnormal premyofibril maturation, impaired heart development, pericardial effusion and embryonic lethality.
 
Interactions
Fhod3 interacts with 171 markers (Mir7-2, Mir7b, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process actin filament network formation, actin filament organization, ...
Component cytoplasm, cytoskeleton, ...
Function actin binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (140)    Tissues (35)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 140
cDNA source data(50)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) cDNA(50) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000034295 (Evidence)
Entrez Gene225288 (Evidence)
UniGene329322
DFCITC1580409, TC1590438, TC1594016
Consensus CDS ProjectCCDS29104.1
International Mouse Knockout Project StatusFhod3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034295 Ensembl Gene Model | MGI Sequence Detail 424056 C57BL/6J ±  kb
transcript ENSMUST00000037097 Ensembl | MGI Sequence Detail 5408 Not Applicable 
polypeptide ENSMUSP00000041361 Ensembl | MGI Sequence Detail 1578 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(14) UniProt(3)
Polymorphisms
SNPs within 2kb(3315 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015425 Actin-binding FH2
InterPro IPR016024 Armadillo-type fold
InterPro IPR014767 Diaphanous autoregulatory
InterPro IPR014768 GTPase-binding/formin homology 3
Protein Ontology PR:000007517 FH1/FH2 domain-containing protein 3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:196918 Iskratsch T, et al., Two distinct phosphorylation events govern the function of muscle FHOD3. Cell Mol Life Sci. 2013 Mar;70(5):893-908
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory