Cnih4 MGI Mouse Gene Detail - MGI:1925828 - cornichon family AMPA receptor auxiliary protein 4

Symbol

Cnih4
Name

cornichon family AMPA receptor auxiliary protein 4
Synonyms

D530030D03Rik, E430023H19Rik

Feature Type

protein coding gene
IDs

MGI:1925828
NCBI Gene: 98417
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:180977437-180996559 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 84.53 cM, cytoband H4
Mapping Data

3 experiments

SNPs within 2kb

512 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925828	protein coding gene	Chr1:180972258-180996559 (+)
129S1/SvImJ	ENSMUSG00200021682	protein coding gene	Chr1:178726161-178750462 (+)
A/J	ENSMUSG00195038379	protein coding gene	Chr1:178342299-178366575 (+)
AKR/J	ENSMUSG00220019190	protein coding gene	Chr1:177576837-177601200 (+)
BALB/cJ	ENSMUSG00180033151	protein coding gene	Chr1:178377377-178401680 (+)
C3H/HeJ	ENSMUSG00175036336	protein coding gene	Chr1:178553176-178577474 (+)
C57BL/6NJ	ENSMUSG00215012340	protein coding gene	Chr1:177777865-177802168 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014990	protein coding gene	Chr1:171029900-171054314 (+)
CAST/EiJ	ENSTCUG00005042788	protein coding gene	Chr1:176303837-176328180 (+)
CBA/J	ENSMUSG00210018432	protein coding gene	Chr1:178224958-178249462 (+)
DBA/2J	ENSMUSG00185034891	protein coding gene	Chr1:182844359-182868862 (+)
FVB/NJ	ENSMUSG00205031073	protein coding gene	Chr1:177273886-177298244 (+)
JF1/MsJ	ENSUMUG00000014966	protein coding gene	Chr1:181823536-181847774 (+)
LP/J	ENSMUSG00230027255	protein coding gene	Chr1:182391635-182415936 (+)
NOD/ShiLtJ	ENSMUSG00190027932	protein coding gene	Chr1:178239003-178263308 (+)
NZO/HlLtJ	ENSMUSG00225009542	protein coding gene	Chr1:186143996-186168338 (+)
PWK/PhJ	ENSLUMG00010015483	protein coding gene	Chr1:177084511-177108798 (+)
SPRET/EiJ	ENSMSPG00010029215	protein coding gene	Chr1:180564079-180588955 (+)
WSB/EiJ	ENSIUOG00005011418	protein coding gene	Chr1:177452359-177476708 (+)

Human Ortholog

CNIH4, cornichon family member 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CNIH4, cornichon family member 4
Synonyms

CNIH-4, HSPC163
Links

HGNC:25013

NCBI Gene ID: 29097

UniProt: Q9P003
Chr Location

1q42.11; chr1:224356803-224379459 (+) GRCh38

MGI Vertebrate Homology

Cnih4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CNIH4
Gene Tree

Cnih4

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

60
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

53
Targeted

3
Genomic Mutations

2 involving Cnih4
Incidental Mutations

APF
Find Mice (IMSR)

22 strains or lines available

Despite mild defects in sperm number, motility and morphology, mice homozygous for a knock-out allele exhibit normal fertility in both sexes with no detectable defects in spermatogenesis or oogenesis.

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All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

75

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cnih4

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All Sequences

48
RefSeq

4
UniProt

3
CCDS

CCDS15582.1

Ensembl

ENSMUSG00000062169 (Evidence)
NCBI Gene

98417

			Length	Strain/Species	Flank
genomic	98417	NCBI Gene Model \| MGI Sequence Detail	19123	C57BL/6J	± kb
transcript	NM_030131	RefSeq \| MGI Sequence Detail	3283	C57BL/6
polypeptide	Q9CX13	UniProt \| EBI \| MGI Sequence Detail	139	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005636 protein cornichon homolog 4

(term hierarchy)
InterPro Domains

IPR003377 Cornichon

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All nucleic 75

cDNA 75

Microarray probesets 5

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MGI:2138312, MGI:2138553

Summaries

All 40

Gene Ontology 5

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:333288 Dil S, et al., Cornichon protein CNIH4 is not essential for mice gametogenesis and fertility. Dev Biol. 2023 Jan 16;496:15-23

TSS for Cnih4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10516	Chr1:180978491-180978549 (+)	1,083 bp
Tssr326	Chr1:180978570-180978581 (+)	1,139 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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