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Gpr124
Gene Detail
Symbol

Name
ID
Gpr124
G protein-coupled receptor 124
MGI:1925810
Synonyms
8430414O08Rik, 9530074E10Rik, mKIAA1531, Tem5
Feature Type
protein coding gene
Genetic Map
Chromosome 8
15.91 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:27085583-27123436 bp, + strand
From VEGA annotation of GRCm38

  37854 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13112  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: probable G protein-coupled receptors 124 and 125
Gene Tree: Gpr124

Human
homologs
Human Homolog GPR124, G protein-coupled receptor 124
NCBI Gene ID 25960
neXtProt AC  NX_Q96PE1
Human Synonyms  TEM5
Human Chr (Location)  8p11.23; chr8:37796883-37843986 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(4) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for null mutations display fetal or perinatal lethality with CNS hemorrhage and angiogenic arrest in the CNS.
 
Interactions
Gpr124 interacts with 249 markers (Mir1a-2, Mir1b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process angiogenesis, cell surface receptor signaling pathway, ...
Component cell surface, integral component of membrane, ...
Function G-protein coupled receptor activity, signal transducer activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (61)    Tissues (45)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 41
In situ reporter (knock in) 14
Northern blot 6
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000042301 (Evidence)
Ensembl Gene ModelENSMUSG00000031486 (Evidence)
Entrez Gene78560 (Evidence)
DFCITC1600629, TC1581058
DoTSDT.101380882
NIA Mouse Gene IndexU009214
Consensus CDS ProjectCCDS22210.2
International Mouse Knockout Project StatusGpr124
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042301 VEGA Gene Model | MGI Sequence Detail 37854 C57BL/6J ±  kb
transcript OTTMUST00000111291 VEGA | MGI Sequence Detail 5760 Not Applicable 
polypeptide OTTMUSP00000062272 VEGA | MGI Sequence Detail 1336 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(10) UniProt(7)
Polymorphisms
SNPs within 2kb(201 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
InterPro IPR000203 GPS domain
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR001611 Leucine-rich repeat
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000031416 G-protein coupled receptor 124
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:200671 Economides AN, et al., Conditionals by inversion provide a universal method for the generation of conditional alleles. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3179-88
All references(38)
Other
accession IDs
MGI:1918709

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory