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Arhgap10 Gene Detail
Summary
  • Symbol
    Arhgap10
  • Name
    Rho GTPase activating protein 10
  • Synonyms
    A930033B01Rik, PSGAP-m, PSGAP-s
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925764
    NCBI Gene: 78514
Location & Maps
more
  • Sequence Map
    Chr8:77250366-77517953 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      267588 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 36.60 cM, cytoband C2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ARHGAP10, Rho GTPase activating protein 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARHGAP10, Rho GTPase activating protein 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GRAF2, PSGAP, PS-GAP
  • Links
    NCBI Gene ID: 79658
    neXtProt AC: NX_A1A4S6

  • Chr Location
    4q31.23; chr4:147732063-148072779 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Targeted
    2
  • Genomic Mutations
    1 involving Arhgap10
  • Incidental Mutations
Mice homozygous for an ENU-induced allele exhibit paraparesis, ataxic hindlimbs and splaying of hindlimbs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000061241 VEGA Gene Model | MGI Sequence Detail 267588 C57BL/6J ±  kb
transcript OTTMUST00000149496 VEGA | MGI Sequence Detail 3084 Not Applicable  
polypeptide OTTMUSP00000077566 VEGA | MGI Sequence Detail 786 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1966 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    cDNA 31

    Microarray probesets 2
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:162220 Magdaleno S, et al., BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory