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Cul9
Gene Detail
Symbol

Name
ID
Cul9
cullin 9
MGI:1925559
Synonyms
1810035I07Rik, mKIAA0708, Parc
Feature Type
protein coding gene
Genetic Map
Chromosome 17
22.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:46500572-46546388 bp, - strand
From VEGA annotation of GRCm38

  45817 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56696  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Cul9

Human
homologs
Human Homolog CUL9, cullin 9
NCBI Gene ID 23113
neXtProt AC  NX_Q8IWT3
Human Synonyms  H7AP1, PARC
Human Chr (Location)  6p21.1; chr6:43182175-43224587 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased body weight, increased incidence of tumors, and decreased cellular sensitivity to radiation-induced apoptosis.
 
Interactions
Cul9 interacts with 76 markers (Mir15b, Mir18, Mir18b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process microtubule cytoskeleton organization, protein ubiquitination, ...
Component cullin-RING ubiquitin ligase complex, cytoplasm
Function ATP binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (12)    Tissues (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 11
RT-PCR 1
cDNA source data(38)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) cDNA(40) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000043230 (Evidence)
Ensembl Gene ModelENSMUSG00000040327 (Evidence)
Entrez Gene78309 (Evidence)
UniGene329076
DFCITC1579200, TC1596517, TC1601132, TC1605699, TC1612970, TC1637670, TC1643250
DoTSDT.101722853, DT.110564818, DT.40154743, DT.55164445, DT.91366451, DT.94198721, DT.99657166
NIA Mouse Gene IndexU041209
Consensus CDS ProjectCCDS37636.2
International Mouse Knockout Project StatusCul9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043230 VEGA Gene Model | MGI Sequence Detail 45817 C57BL/6J ±  kb
transcript OTTMUST00000113461 VEGA | MGI Sequence Detail 7848 Not Applicable 
polypeptide OTTMUSP00000063478 VEGA | MGI Sequence Detail 2530 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(13) UniProt(3)
Polymorphisms
SNPs within 2kb(240 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004939 Anaphase-promoting complex, subunit 10/DOC domain
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR021097 CPH domain
InterPro IPR016157 Cullin, conserved site
InterPro IPR016158 Cullin homology
InterPro IPR001373 Cullin, N-terminal
InterPro IPR019559 Cullin protein, neddylation domain
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR014722 Ribosomal protein L2 domain 2
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
InterPro IPR002867 Zinc finger, C6HC-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000006053 cullin-9
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:170976 Pei XH, et al., Cytoplasmic CUL9/PARC Ubiquitin Ligase Is a Tumor Suppressor and Promotes p53-Dependent Apoptosis. Cancer Res. 2011 Apr 15;71(8):2969-77
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory