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Gpr108 Gene Detail
Summary
  • Symbol
    Gpr108
  • Name
    G protein-coupled receptor 108
  • Synonyms
    1810015L19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925558
    NCBI Gene: 78308
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:57541635-57555446 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.74 cM, cytoband E1.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    355 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925558
 protein coding gene Chr17:57541635-57555743 (-)
129S1/SvImJ ENSMUSG00200016082
 protein coding gene Chr17:52817704-52830759 (-)
A/J ENSMUSG00195006574
 protein coding gene Chr17:54205883-54218942 (-)
AKR/J ENSMUSG00220013043
 protein coding gene Chr17:53255241-53268292 (-)
BALB/cJ ENSMUSG00180005692
 protein coding gene Chr17:53963546-53976628 (-)
C3H/HeJ ENSMUSG00175007209
 protein coding gene Chr17:53279509-53292562 (-)
C57BL/6NJ ENSMUSG00215005911
 protein coding gene Chr17:52893138-52906196 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021811
 protein coding gene Chr17:53834544-53847653 (-)
CAST/EiJ ENSTCUG00005018144
 protein coding gene Chr17:54009074-54022254 (-)
CBA/J ENSMUSG00210026644
 protein coding gene Chr17:53046569-53059618 (-)
DBA/2J ENSMUSG00185008138
 protein coding gene Chr17:55916409-55929459 (-)
FVB/NJ ENSMUSG00205006640
 protein coding gene Chr17:53593946-53606996 (-)
JF1/MsJ ENSUMUG00000017388
 protein coding gene Chr17:55600152-55613222 (-)
LP/J ENSMUSG00230025766
 protein coding gene Chr17:56895035-56908089 (-)
NOD/ShiLtJ ENSMUSG00190009754
 protein coding gene Chr17:53048568-53061630 (-)
NZO/HlLtJ ENSMUSG00225042423
 protein coding gene Chr17:59179027-59192082 (-)
PWK/PhJ ENSLUMG00010008655
 protein coding gene Chr17:52852462-52865571 (-)
SPRET/EiJ ENSMSPG00010005377
 protein coding gene Chr17:53178851-53191746 (-)
WSB/EiJ ENSIUOG00005022805
 protein coding gene Chr17:53954921-53967968 (-)



Homology
more
  • Human Ortholog
    GPR108, G protein-coupled receptor 108
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR108, G protein-coupled receptor 108
  • Synonyms
    LUSTR2
  • Links
    NCBI Gene ID: 56927
    UniProt: Q9NPR9

  • Chr Location
    19p13.3; chr19:6729914-6737606 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased LPS-induced mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    100
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005823 Ensembl Gene Model | MGI Sequence Detail 13812 C57BL/6J ±  kb
    transcript ENSMUST00000233568 Ensembl | MGI Sequence Detail 2405 Not Applicable  
    polypeptide ENSMUSP00000156910 Ensembl | MGI Sequence Detail 569 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 100
      cDNA 100

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146772, MGI:2147129
    References
    more
    • Summaries
      All 44
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory