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Gpr108 Gene Detail
Summary
  • Symbol
    Gpr108
  • Name
    G protein-coupled receptor 108
  • Synonyms
    1810015L19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925558
    NCBI Gene: 78308
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:57234914-57248441 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.74 cM, cytoband E1.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    30 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925558
protein coding gene Chr17:57234635-57248446 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023960
protein coding gene Chr17:59007999-59023013 (-)
A/J MGP_AJ_G0023918
protein coding gene Chr17:57365937-57378665 (-)
AKR/J MGP_AKRJ_G0023887
protein coding gene Chr17:58093304-58105795 (-)
BALB/cJ MGP_BALBcJ_G0023919
protein coding gene Chr17:57203778-57216710 (-)
C3H/HeJ MGP_C3HHeJ_G0023683
protein coding gene Chr17:58810103-58822728 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024365
protein coding gene Chr17:61300375-61313090 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021811
protein coding gene Chr17:53834544-53847653 (-)
CAST/EiJ MGP_CASTEiJ_G0023165
protein coding gene Chr17:59121110-59135294 (-)
CBA/J MGP_CBAJ_G0023659
protein coding gene Chr17:63695827-63708780 (-)
DBA/2J MGP_DBA2J_G0023787
protein coding gene Chr17:56056815-56069466 (-)
FVB/NJ MGP_FVBNJ_G0023753
protein coding gene Chr17:55634984-55649024 (-)
LP/J MGP_LPJ_G0023869
protein coding gene Chr17:59687218-59700670 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023781
protein coding gene Chr17:63122985-63136602 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024409
protein coding gene Chr17:58455602-58468269 (-)
PWK/PhJ MGP_PWKPhJ_G0022911
protein coding gene Chr17:55427574-55441024 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022722
protein coding gene Chr17:55230871-55243385 (-)
WSB/EiJ MGP_WSBEiJ_G0023231
protein coding gene Chr17:59090753-59104453 (-)



Homology
more
  • Human Ortholog
    GPR108, G protein-coupled receptor 108
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GPR108, G protein-coupled receptor 108
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LUSTR2
  • Links
    NCBI Gene ID: 56927
    neXtProt AC: NX_Q9NPR9
    UniProt: Q9NPR9

  • Chr Location
    19p13.3; chr19:6729914-6737622 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased LPS-induced mortality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 78308 NCBI Gene Model | MGI Sequence Detail 13528 C57BL/6J ±  kb
transcript NM_030084 RefSeq | MGI Sequence Detail 2157 C57BL/6  
polypeptide Q91WD0 UniProt | EBI | MGI Sequence Detail 569 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 100
    cDNA 100

    Microarray probesets 3
Other
Accession IDs
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MGI:2146772, MGI:2147129
References
more
  • Summaries
    All 35
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:266821 Dong D, et al., GPR108, an NF-kappaB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses. PLoS One. 2018;13(10):e0205303

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory