Tbcel MGI Mouse Gene Detail - MGI:1925543 - tubulin folding cofactor E-like

Symbol

Tbcel
Name

tubulin folding cofactor E-like
Synonyms

E130107N23Rik, Lrrc35

Feature Type

protein coding gene
IDs

MGI:1925543
NCBI Gene: 272589
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr9:42323612-42383534 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 23.71 cM
Mapping Data

1 experiment

SNPs within 2kb

367 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925543	protein coding gene	Chr9:42323612-42419105 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034678	protein coding gene	Chr9:40758210-40855326 (-)
A/J	MGP_AJ_G0034658	protein coding gene	Chr9:39673706-39770196 (-)
AKR/J	MGP_AKRJ_G0034584	protein coding gene	Chr9:40446167-40543533 (-)
BALB/cJ	MGP_BALBcJ_G0034649	protein coding gene	Chr9:39404878-39500501 (-)
C3H/HeJ	MGP_C3HHeJ_G0034360	protein coding gene	Chr9:40940480-41036908 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035172	protein coding gene	Chr9:42022336-42123918 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032085	protein coding gene	Chr9:39285926-39387715 (-)
CAST/EiJ	MGP_CASTEiJ_G0033683	protein coding gene	Chr9:40745931-40843719 (-)
CBA/J	MGP_CBAJ_G0034333	protein coding gene	Chr9:43510709-43612242 (-)
DBA/2J	MGP_DBA2J_G0034492	protein coding gene	Chr9:39592683-39689550 (-)
FVB/NJ	MGP_FVBNJ_G0034432	protein coding gene	Chr9:38822338-38917891 (-)
LP/J	MGP_LPJ_G0034573	protein coding gene	Chr9:41035170-41139296 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034476	protein coding gene	Chr9:45478400-45575256 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035191	protein coding gene	Chr9:40353441-40450540 (-)
PWK/PhJ	MGP_PWKPhJ_G0033388	protein coding gene	Chr9:39423369-39521089 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033224	protein coding gene	Chr9:40617429-40717028 (-)
WSB/EiJ	MGP_WSBEiJ_G0033796	protein coding gene	Chr9:40392548-40491949 (-)

Human Ortholog

TBCEL, tubulin folding cofactor E like

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TBCEL, tubulin folding cofactor E like
Synonyms

El, LRRC35
Links

HGNC:28115

NCBI Gene ID: 219899

neXtProt AC: NX_Q5QJ74

UniProt: Q5QJ74
Chr Location

11q23.3; chr11:121024072-121090776 (+) GRCh38

MGI Vertebrate Homology

Tbcel stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TBCEL
Gene Tree

Tbcel

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

94
Endonuclease-mediated

3
Gene trapped

85
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

84 strains or lines available

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All GO Annotations

6
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

66

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tbcel

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All Sequences

67
RefSeq

10
UniProt

3
CCDS

CCDS23088.1, CCDS90542.1

Ensembl

ENSMUSG00000037287 (Evidence)
NCBI Gene

272589

			Length	Strain/Species	Flank
genomic	272589	NCBI Gene Model \| MGI Sequence Detail	59923	C57BL/6J	± kb
transcript	NM_173038	RefSeq \| MGI Sequence Detail	4980	C57BL/6
polypeptide	Q8C5W3	UniProt \| EBI \| MGI Sequence Detail	424	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016130 tubulin-specific chaperone cofactor E-like protein

(term hierarchy)
InterPro Domains

IPR032675 Leucine-rich repeat domain superfamily

IPR047991 Tubulin-specific chaperone cofactor E-like protein, ubiquitin-like domain

IPR000626 Ubiquitin-like domain

IPR029071 Ubiquitin-like domain superfamily

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All nucleic 66

cDNA 66

Microarray probesets 6

Summaries

All 33

Gene Ontology 2

Phenotypes 12
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Tbcel:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr89060	Chr9:42383494-42383559 (-)	7 bp
Tssr89059	Chr9:42375098-42375118 (-)	8,426 bp
Tssr89058	Chr9:42372710-42372732 (-)	10,813 bp
Tssr89057	Chr9:42372688-42372703 (-)	10,838 bp
Tssr89056	Chr9:42372673-42372684 (-)	10,855 bp
Tssr89055	Chr9:42368890-42368902 (-)	14,638 bp
Tssr89054	Chr9:42368882-42368887 (-)	14,649 bp
Tssr89053	Chr9:42350845-42350882 (-)	32,670 bp
Tssr89052	Chr9:42339494-42339505 (-)	44,034 bp
Tssr89051	Chr9:42339477-42339493 (-)	44,049 bp
Tssr89050	Chr9:42339449-42339459 (-)	44,080 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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