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Ddo Gene Detail
Summary
  • Symbol
    Ddo
  • Name
    D-aspartate oxidase
  • Synonyms
    5330420D20Rik, 5730402C02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925528
    NCBI Gene: 70503
  • Gene Overview
    MyGene.info: DDO
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:40630011-40681847 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 22.00 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    464 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925528
protein coding gene Chr10:40629975-40681847 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017165
protein coding gene Chr10:39227237-39251901 (+)
A/J MGP_AJ_G0017142
protein coding gene Chr10:38138850-38160225 (+)
AKR/J MGP_AKRJ_G0017102
protein coding gene Chr10:38693997-38714105 (+)
BALB/cJ MGP_BALBcJ_G0017104
protein coding gene Chr10:38226221-38244880 (+)
C3H/HeJ MGP_C3HHeJ_G0016925
protein coding gene Chr10:39015111-39037951 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017563
protein coding gene Chr10:40436935-40463101 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015259
protein coding gene Chr10:36105743-36125819 (+)
CAST/EiJ MGP_CASTEiJ_G0016504
protein coding gene Chr10:39212196-39236527 (+)
CBA/J MGP_CBAJ_G0016899
protein coding gene Chr10:42273663-42294559 (+)
DBA/2J MGP_DBA2J_G0017004
protein coding gene Chr10:37660474-37680021 (+)
FVB/NJ MGP_FVBNJ_G0016999
protein coding gene Chr10:37154158-37174082 (+)
LP/J MGP_LPJ_G0017081
protein coding gene Chr10:39214762-39236909 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017029
protein coding gene Chr10:43110069-43131767 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017600
protein coding gene Chr10:38670657-38693417 (+)
PWK/PhJ MGP_PWKPhJ_G0016284
protein coding gene Chr10:37539764-37559571 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016068
protein coding gene Chr10:38507266-38525826 (+)
WSB/EiJ MGP_WSBEiJ_G0016567
protein coding gene Chr10:39007058-39036932 (+)



Homology
more
  • Human Ortholog
    DDO, D-aspartate oxidase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    DDO, D-aspartate oxidase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DASOX, DDO-1, DDO-2
  • Links
    NCBI Gene ID: 8528
    neXtProt AC: NX_Q99489
    UniProt: Q99489

  • Chr Location
    6q21; chr6:110392180-110415550 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and fertile, but can display impaired male copulation, decreased autogrooming, increased body weight, and increased D-aspartate levels, depending on the mutant allele.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063428 Ensembl Gene Model | MGI Sequence Detail 51837 C57BL/6J ±  kb
    transcript ENSMUST00000019977 Ensembl | MGI Sequence Detail 3000 Not Applicable  
    polypeptide ENSMUSP00000019977 Ensembl | MGI Sequence Detail 341 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 24

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917753, MGI:2143623
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:231660 Punzo D, et al., Age-Related Changes in d-Aspartate Oxidase Promoter Methylation Control Extracellular d-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging. J Neurosci. 2016 Mar 9;36(10):3064-78

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory