Ralgps2
Gene Detail

Symbol Name ID

Ralgps2 Ral GEF with PH domain and SH3 binding motif 2 MGI:1925505

Synonyms

1810020P17Rik, 2210408F11Rik, 4921528G01Rik, 9130014M22Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 1

67.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:156804166-156939626 bp, - strand From NCBI annotation of GRCm38   135461 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:23421  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ralgps2

Human homologs

Human Homolog		RALGPS2, Ral GEF with PH domain and SH3 binding motif 2
NCBI Gene ID		55103
neXtProt AC		NX_Q86X27
Human Synonyms		dJ595C2.1
Human Chr (Location)		1q25.2; chr1:178694300-178889238 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(27) : Targeted(2) Gene trapped(25)

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	small GTPase mediated signal transduction
Component	cytoplasm, intracellular, ...
Function	guanyl-nucleotide exchange factor activity, phospholipid binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (185)    Tissues (29)    Images (20)
Theiler Stages: 23

Assay Type	Results
RNA in situ	185

cDNA source data(190)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(192) cDNA(192)
Microarray probesets(7)

Other database links

Ensembl Gene Model	ENSMUSG00000026594 (Evidence)
Entrez Gene	78255 (Evidence)
UniGene	28376
DFCI	TC1575722, TC1590020, TC1592643, TC1602323, TC1604527, TC1676598
DoTS	DT.101402442, DT.101402444, DT.101402446, DT.110922748, DT.489736, DT.490592, DT.55138122, DT.55170784, DT.87056706, DT.91564422, DT.97404169
NIA Mouse Gene Index	U021932, U196079
Consensus CDS Project	CCDS15396.1, CCDS48405.1, CCDS48406.1
International Mouse Knockout Project Status	Ralgps2

Sequences

Length	Strain/Species
genomic	78255	NCBI Gene Model | MGI Sequence Detail	135461	C57BL/6J
transcript	NR_027640	RefSeq | MGI Sequence Detail	7019	C57BL/6
polypeptide	Q9ERD6	UniProt | EBI | MGI Sequence Detail	590	Not Applicable

All sequences(70) RefSeq(11) UniProt(2)

Polymorphisms

SNPs(976 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001895	Guanine-nucleotide dissociation stimulator CDC25
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR008937	Ras guanine nucleotide exchange factor
InterPro	IPR023578	Ras guanine nucleotide exchange factor, domain
Protein Ontology	PR:000013700	ras-specific guanine nucleotide-releasing factor RalGPS2

Graphical View of Protein Domain Structure

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
All references(36)

Other accession IDs

MGI:1916362, MGI:1917389, MGI:1921815, MGI:2138499, MGI:2138540