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Ralgps2 Gene Detail
Summary
  • Symbol
    Ralgps2
  • Name
    Ral GEF with PH domain and SH3 binding motif 2
  • Synonyms
    1810020P17Rik, 2210408F11Rik, 4921528G01Rik, 9130014M22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925505
    NCBI Gene: 78255
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:156804166-156939626 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      135461 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 67.71 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RALGPS2, Ral GEF with PH domain and SH3 binding motif 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RALGPS2, Ral GEF with PH domain and SH3 binding motif 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ595C2.1
  • Links
    NCBI Gene ID: 55103
    neXtProt AC: NX_Q86X27
    UniProt: Q86X27

  • Chr Location
    1q25.2; chr1:178725147-178921842 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000049722 VEGA Gene Model | MGI Sequence Detail 135461 C57BL/6J ±  kb
    transcript OTTMUST00000126738 VEGA | MGI Sequence Detail 3346 Not Applicable  
    polypeptide OTTMUSP00000068511 VEGA | MGI Sequence Detail 590 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1443 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000013700 ras-specific guanine nucleotide-releasing factor RalGPS2
    • InterPro Domains
      IPR011993 PH-like domain superfamily
      IPR001849 Pleckstrin homology domain
      IPR036964 Ras guanine-nucleotide exchange factor catalytic domain superfamily
      IPR023578 Ras guanine nucleotide exchange factor domain superfamily
      IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
      IPR030708 Ras-specific guanine nucleotide-releasing factor RalGPS1/2
    Molecular
    Reagents
    less
    • All nucleic 194
      cDNA 193
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1916362, MGI:1917389, MGI:1921815, MGI:2138499, MGI:2138540
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 5
      Gene Ontology 2
      Phenotypes 10
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:245876 Rohacek AM, et al., ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development. Dev Cell. 2017 Nov 06;43(3):318-331.e5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory