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Ralgps2 Gene Detail
Summary
  • Symbol
    Ralgps2
  • Name
    Ral GEF with PH domain and SH3 binding motif 2
  • Synonyms
    1810020P17Rik, 2210408F11Rik, 4921528G01Rik, 9130014M22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925505
    NCBI Gene: 78255
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:156804166-156939626 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 67.71 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1443 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925505
protein coding gene Chr1:156804166-156939838 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016628
protein coding gene Chr1:161785814-161924976 (-)
A/J MGP_AJ_G0016609
protein coding gene Chr1:155278913-155412884 (-)
AKR/J MGP_AKRJ_G0016575
protein coding gene Chr1:160018254-160155353 (-)
BALB/cJ MGP_BALBcJ_G0016570
protein coding gene Chr1:155773913-155911628 (-)
C3H/HeJ MGP_C3HHeJ_G0016394
protein coding gene Chr1:160153459-160283719 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017031
protein coding gene Chr1:167330054-167481797 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014740
protein coding gene Chr1:147471045-147607604 (-)
CAST/EiJ MGP_CASTEiJ_G0015974
protein coding gene Chr1:159702760-159840217 (-)
CBA/J MGP_CBAJ_G0016369
protein coding gene Chr1:173251775-173403401 (-)
DBA/2J MGP_DBA2J_G0016475
protein coding gene Chr1:154223432-154357252 (-)
FVB/NJ MGP_FVBNJ_G0016473
protein coding gene Chr1:152684770-152815764 (-)
LP/J MGP_LPJ_G0016546
protein coding gene Chr1:162906407-163046600 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016498
protein coding gene Chr1:180756351-180906195 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017067
protein coding gene Chr1:159837295-159981232 (-)
PWK/PhJ MGP_PWKPhJ_G0015760
protein coding gene Chr1:153322424-153455553 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015547
protein coding gene Chr1:158580614-158715080 (-)
WSB/EiJ MGP_WSBEiJ_G0016036
protein coding gene Chr1:159939763-160077378 (-)



Homology
more
  • Human Ortholog
    RALGPS2, Ral GEF with PH domain and SH3 binding motif 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RALGPS2, Ral GEF with PH domain and SH3 binding motif 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ595C2.1
  • Links
    NCBI Gene ID: 55103
    neXtProt AC: NX_Q86X27
    UniProt: Q86X27

  • Chr Location
    1q25.2; chr1:178725147-178921842 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026594 Ensembl Gene Model | MGI Sequence Detail 135461 C57BL/6J ±  kb
transcript ENSMUST00000171292 Ensembl | MGI Sequence Detail 3346 Not Applicable  
polypeptide ENSMUSP00000130581 Ensembl | MGI Sequence Detail 590 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000013700 ras-specific guanine nucleotide-releasing factor RalGPS2
  • InterPro Domains
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
    IPR036964 Ras guanine-nucleotide exchange factor catalytic domain superfamily
    IPR023578 Ras guanine nucleotide exchange factor domain superfamily
    IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
    IPR008937 Ras-like guanine nucleotide exchange factor
    IPR030708 Ras-specific guanine nucleotide-releasing factor RalGPS1/2
Molecular
Reagents
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  • All nucleic 196
    cDNA 195
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGI:1916362, MGI:1917389, MGI:1921815, MGI:2138499, MGI:2138540
References
more
  • Summaries
    All 39
    Developmental Gene Expression 5
    Gene Ontology 2
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:245876 Rohacek AM, et al., ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development. Dev Cell. 2017 Nov 06;43(3):318-331.e5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory