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Map4k5
Gene Detail
Symbol

Name
ID
Map4k5
mitogen-activated protein kinase kinase kinase kinase 5
MGI:1925503
Synonyms
4432415E19Rik, GCKR, KHS, MAPKKKK5
Feature Type
protein coding gene
Genetic Map
Chromosome 12
28.94 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:69803750-69893200 bp, - strand
From VEGA annotation of GRCm38

  89451 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38199  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MAP4K5
Protein SuperFamily: mitogen-activated protein kinase kinase kinase kinase
Gene Tree: Map4k5

Human
homologs
MAP4K5, mitogen-activated protein kinase kinase kinase kinase 5
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 11183
neXtProt AC: NX_Q9Y4K4

Human Synonyms: GCKR, KHS, KHS1, MAPKKKK5

Human Chr (Location): 14q11.2-q21; chr14:50418480-50561126 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(37) : Gene trapped(34) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele are viable and phenotypically normal but show impaired canonical and noncanonical Wnt signaling in progenitor B lymphocytes. Mice homozygous for a gene trap exhibit hypoalgesia, increased serum IgG1 and an increased percentage of peripheral blood CD4+ cells.
 
Interactions
Map4k5 interacts with 306 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process activation of MAPKKK activity, activation of protein kinase activity, ...
Component cytoplasm, plasma membrane
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
cDNA source data(107)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase map4k5 ; ZFIN map4k5    NEW 
Molecular
reagents
All nucleic(108) cDNA(108)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000017571 (Evidence)
Ensembl Gene Model ENSMUSG00000034761 (Evidence)
Entrez Gene 399510 (Evidence)
UniGene 291936
DFCI TC1575154, TC1584686, TC1596733, TC1597398, TC1607315, TC1780950
DoTS DT.101213142, DT.101391518, DT.110954612, DT.528642, DT.91310971, DT.99851279
NIA Mouse Gene Index U034040
EC 2.7.11.1
International Mouse Phenotyping Consortium Status Map4k5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017571 VEGA Gene Model | MGI Sequence Detail 89451 C57BL/6J ±  kb
transcript OTTMUST00000042725 VEGA | MGI Sequence Detail 4498 Not Applicable 
polypeptide OTTMUSP00000019191 VEGA | MGI Sequence Detail 847 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(665 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001180 Citron homology (CNH) domain
InterPro IPR021160 Mitogen-activated protein (MAP) kinase kinase kinase kinase
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
Protein Ontology PR:000010146 mitogen-activated protein kinase kinase kinase kinase 5
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory