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Adgrf4 Gene Detail
Summary
  • Symbol
    Adgrf4
  • Name
    adhesion G protein-coupled receptor F4
  • Synonyms
    4632435A09Rik, Gpr115
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925499
    NCBI Gene: 78249
  • Gene Overview
    MyGene.info: ADGRF4
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:42656891-42692284 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 19.65 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    577 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925499
protein coding gene Chr17:42656887-42697569 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023768
protein coding gene Chr17:43505422-43544365 (-)
A/J MGP_AJ_G0023726
protein coding gene Chr17:42530955-42566432 (-)
AKR/J MGP_AKRJ_G0023697
protein coding gene Chr17:42719663-42755877 (-)
BALB/cJ MGP_BALBcJ_G0023730
protein coding gene Chr17:42434032-42471776 (-)
C3H/HeJ MGP_C3HHeJ_G0023494
protein coding gene Chr17:43417753-43454189 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024172
protein coding gene Chr17:45393603-45441927 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021623
protein coding gene Chr17:39433671-39468503 (-)
CAST/EiJ MGP_CASTEiJ_G0022975
protein coding gene Chr17:43426762-43471734 (-)
CBA/J MGP_CBAJ_G0023470
protein coding gene Chr17:47058629-47098910 (-)
DBA/2J MGP_DBA2J_G0023596
protein coding gene Chr17:41344475-41380354 (-)
FVB/NJ MGP_FVBNJ_G0023563
protein coding gene Chr17:40906041-40941568 (-)
LP/J MGP_LPJ_G0023677
protein coding gene Chr17:44162119-44197662 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023592
protein coding gene Chr17:46705365-46742174 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024218
protein coding gene Chr17:43044162-43086979 (-)
PWK/PhJ MGP_PWKPhJ_G0022720
protein coding gene Chr17:40597081-40636631 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022535
protein coding gene Chr17:39979768-40014781 (-)
WSB/EiJ MGP_WSBEiJ_G0023040
protein coding gene Chr17:43579174-43622667 (-)



Homology
more
  • Human Ortholog
    ADGRF4, adhesion G protein-coupled receptor F4
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ADGRF4, adhesion G protein-coupled receptor F4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GPR115, PGR18
  • Links
    NCBI Gene ID: 221393
    neXtProt AC: NX_Q8IZF3
    UniProt: Q8IZF3

  • Chr Location
    6p12.3; chr6:47698553-47722021 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele exhibit normal viability and fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023918 Ensembl Gene Model | MGI Sequence Detail 35394 C57BL/6J ±  kb
    transcript ENSMUST00000024711 Ensembl | MGI Sequence Detail 3060 Not Applicable  
    polypeptide ENSMUSP00000024711 Ensembl | MGI Sequence Detail 698 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147025
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:245698 Lu S, et al., Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4). PLoS One. 2017;12(8):e0183166

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory