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Spint4 Gene Detail
Summary
  • Symbol
    Spint4
  • Name
    serine protease inhibitor, Kunitz type 4
  • Synonyms
    9230105I15Rik, Spint4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925489
    NCBI Gene: 78239
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164540421-164544368 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 85.26 cM, cytoband H3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    27 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925489
 protein coding gene Chr2:164540421-164544373 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026867
 protein coding gene Chr2:170187494-170191440 (+)
A/J MGP_AJ_G0026834
 protein coding gene Chr2:163235344-163239294 (+)
AKR/J MGP_AKRJ_G0026805
 protein coding gene Chr2:168083059-168087009 (+)
BALB/cJ MGP_BALBcJ_G0026843
 protein coding gene Chr2:163594044-163597994 (+)
C3H/HeJ MGP_C3HHeJ_G0026585
 protein coding gene Chr2:168447996-168451946 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027290
 protein coding gene Chr2:175119074-175123026 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024661
 protein coding gene Chr2:156647968-156651936 (+)
CAST/EiJ MGP_CASTEiJ_G0026043
 protein coding gene Chr2:168865283-168869277 (+)
CBA/J MGP_CBAJ_G0026562
 protein coding gene Chr2:181473759-181477709 (+)
DBA/2J MGP_DBA2J_G0026700
 protein coding gene Chr2:162403590-162407540 (+)
FVB/NJ MGP_FVBNJ_G0026666
 protein coding gene Chr2:160821863-160825813 (+)
LP/J MGP_LPJ_G0026802
 protein coding gene Chr2:170253241-170257187 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026685
 protein coding gene Chr2:185033773-185037723 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027347
 protein coding gene Chr2:167988417-167992365 (+)
PWK/PhJ MGP_PWKPhJ_G0025780
 protein coding gene Chr2:162001663-162005650 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025581
 protein coding gene Chr2:166896877-166900841 (+)
WSB/EiJ MGP_WSBEiJ_G0026116
 protein coding gene Chr2:168874622-168878578 (+)



Homology
more
  • Human Ortholog
    SPINT4, serine peptidase inhibitor, Kunitz type 4
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPINT4, serine peptidase inhibitor, Kunitz type 4
  • Synonyms
    C20orf137, dJ601O1.1, SPINT3
  • Links
    NCBI Gene ID: 391253
    neXtProt AC: NX_Q6UDR6
    UniProt: Q6UDR6

  • Chr Location
    20q13.12; chr20:45722347-45725830 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    13
  • cDNA Data
    4
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 78239 NCBI Gene Model | MGI Sequence Detail 3948 C57BL/6J ±  kb
transcript NM_030058 RefSeq | MGI Sequence Detail 746 C57BL/6  
polypeptide Q9D263 UniProt | EBI | MGI Sequence Detail 159 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000015545 Kunitz-type protease inhibitor 4
    (term hierarchy)
  • InterPro Domains
    IPR042943 Kunitz-type protease inhibitor 4
    IPR002223 Pancreatic trypsin inhibitor Kunitz domain
    IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily
    IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
Molecular
Reagents
less
  • All nucleic 5
    cDNA 4
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:295177 Robertson MJ, et al., Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets. BMC Biol. 2020 Aug 19;18(1):103
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory