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Mccc2
Gene Detail
Symbol

Name
ID
Mccc2
methylcrotonoyl-Coenzyme A carboxylase 2 (beta)
MGI:1925288
Synonyms
4930552N12Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 13
52.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:99948533-100015639 bp, - strand
From Ensembl annotation of GRCm38

  67107 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11145  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MCCC2
Gene Tree: Mccc2

Human
homologs
MCCC2, methylcrotonoyl-CoA carboxylase 2 (beta)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 64087
neXtProt AC: NX_Q9HCC0

Human Synonyms: MCCB

Human Chr (Location): 5q12-q13; chr5:71587288-71658706 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MCCC2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(3) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Mccc2 interacts with 55 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process coenzyme A metabolic process
Component mitochondrion
Function ATP binding, ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(61)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mccc2 ; ZFIN mccc2    NEW 
Molecular
reagents
All nucleic(61) cDNA(61)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000021646 (Evidence)
Entrez Gene 78038 (Evidence)
UniGene 137327
DFCI TC1581287, TC1589537, TC1601968, TC1602413, TC1645488
DoTS DT.101247363, DT.101372693, DT.101372694, DT.532527, DT.87047376, DT.99849232
NIA Mouse Gene Index U035101
EC 6.4.1.4
Consensus CDS Project CCDS36764.1
International Mouse Phenotyping Consortium Status Mccc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021646 Ensembl Gene Model | MGI Sequence Detail 67107 C57BL/6J ±  kb
transcript ENSMUST00000022148 Ensembl | MGI Sequence Detail 2123 Not Applicable 
polypeptide ENSMUSP00000022148 Ensembl | MGI Sequence Detail 563 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(469 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminal
InterPro IPR011762 Acetyl-coenzyme A carboxyltransferase, N-terminal
InterPro IPR000022 Carboxyl transferase
InterPro IPR029045 ClpP/crotonase-like domain
Protein Ontology PR:000010234 methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory