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Mccc2 Gene Detail
Summary
  • Symbol
    Mccc2
  • Name
    methylcrotonoyl-Coenzyme A carboxylase 2 (beta)
  • Synonyms
    4930552N12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925288
    NCBI Gene: 78038
Location & Maps
more
  • Sequence Map
    Chr13:99948533-100015639 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      67107 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    MCCC2, methylcrotonoyl-CoA carboxylase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MCCC2, methylcrotonoyl-CoA carboxylase 2
    Orthology source: HomoloGene
  • Synonyms
    MCCB
  • Links
    NCBI Gene ID: 64087
    neXtProt AC: NX_Q9HCC0

  • Chr Location
    5q12-q13; chr5:71587288-71658706 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 11145
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MCCC2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MCCC2 associations

Human Disease Mouse Models
       3-methylcrotonyl-Coa Carboxylase 2 Deficiency; MCC2D   OMIM: 210210
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    4
  • Gene trapped
    3
  • Targeted
    1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021646 Ensembl Gene Model | MGI Sequence Detail 67107 C57BL/6J ±  kb
transcript ENSMUST00000022148 Ensembl | MGI Sequence Detail 2123 Not Applicable  
polypeptide ENSMUSP00000022148 Ensembl | MGI Sequence Detail 563 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    469 from dbSNP Build 137
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000010234 methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
  • EC
  • InterPro Domains
    IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminal
    IPR011762 Acetyl-coenzyme A carboxyltransferase, N-terminal
    IPR000022 Carboxyl transferase
    IPR029045 ClpP/crotonase-like domain
Molecular
Reagents
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  • All nucleic 61
    cDNA 61

    Microarray probesets 5
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory