Nuak1 MGI Mouse Gene Detail - MGI:1925226 - NUAK family, SNF1-like kinase, 1

Nuak1 Gene Detail

Symbol

Nuak1
Name

NUAK family, SNF1-like kinase, 1
Synonyms

B230104P22Rik

Feature Type

protein coding gene
IDs

MGI:1925226
NCBI Gene: 77976
Gene Overview

MyGene.info: NUAK1
Alliance

gene page

Sequence Map

Chr10:84370905-84440597 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

69693 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 41.42 cM
Mapping Data

2 experiments

Human Ortholog

NUAK1, NUAK family kinase 1

Vertebrate Orthologs

11

Human Ortholog

NUAK1, NUAK family kinase 1
Orthology source: HomoloGene, HGNC
Synonyms

ARK5
Links

HGNC:14311

NCBI Gene ID: 9891

neXtProt AC: NX_O60285

UniProt: O60285
Chr Location

12q23.3; chr12:106063347-106140033 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 8896
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NUAK1
Gene Tree

Nuak1

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotypes from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Gene trapped

10
Targeted

4
Genomic Mutations

1 involving Nuak1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available

Mice homozygous for a targeted disruption of this gene die perinatally displaying omphalocele with a failure in closure of the secondary body wall. No gross morphological defects are detected in brain.

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All GO Annotations

24
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

241
Tissues

93
cDNA Data

37
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Nuak1 interacts with 341 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

24
RefSeq

4
UniProt

2
CCDS

CCDS24079.1
UniGene

25874

			Length	Strain/Species	Flank
genomic	OTTMUSG00000022766	VEGA Gene Model \| MGI Sequence Detail	69693	C57BL/6J	± kb
transcript	OTTMUST00000054650	VEGA \| MGI Sequence Detail	5558	Not Applicable
polypeptide	OTTMUSP00000026103	VEGA \| MGI Sequence Detail	658	Not Applicable

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SNPs within 2kb

239 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000011473 NUAK family SNF1-like kinase 1

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 39

cDNA 37

Primer pair 2

Microarray probesets 1

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MGI:2143718, MGI:2143843

Summaries

All 40

Developmental Gene Expression 7

Gene Ontology 4

Phenotypes 15
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:253240 Lasagna-Reeves CA, et al., Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model. Neuron. 2016 Oct 19;92(2):407-418

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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