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Nuak1 Gene Detail
Summary
  • Symbol
    Nuak1
  • Name
    NUAK family, SNF1-like kinase, 1
  • Synonyms
    B230104P22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925226
    NCBI Gene: 77976
  • Gene Overview
    MyGene.info: NUAK1
Location & Maps
more
  • Sequence Map
    Chr10:84370905-84440597 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      69693 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 41.42 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NUAK1, NUAK family kinase 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NUAK1, NUAK family kinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARK5
  • Links
    NCBI Gene ID: 9891
    neXtProt AC: NX_O60285

  • Chr Location
    12q23.3; chr12:106063347-106140033 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 8896
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: NUAK1
  • Gene Tree
    Nuak1
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    1
  • Gene trapped
    10
  • Targeted
    4
  • Genomic Mutations
    1 involving Nuak1
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Mice homozygous for a targeted disruption of this gene die perinatally displaying omphalocele with a failure in closure of the secondary body wall. No gross morphological defects are detected in brain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    24
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    241
  • Tissues
    93
  • cDNA Data
    37
  • Literature Summary
    7
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022766 VEGA Gene Model | MGI Sequence Detail 69693 C57BL/6J ±  kb
transcript OTTMUST00000054650 VEGA | MGI Sequence Detail 5558 Not Applicable  
polypeptide OTTMUSP00000026103 VEGA | MGI Sequence Detail 658 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    239 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 39
    cDNA 37
    Primer pair 2

    Microarray probesets 1
Other
Accession IDs
less
MGI:2143718, MGI:2143843
References
more
  • Summaries
    All 34
    Developmental Gene Expression 7
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:200007 Courchet J, et al., Terminal axon branching is regulated by the LKB1-NUAK1 kinase pathway via presynaptic mitochondrial capture. Cell. 2013 Jun 20;153(7):1510-25
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory