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Nuak1 Gene Detail
Summary
  • Symbol
    Nuak1
  • Name
    NUAK family, SNF1-like kinase, 1
  • Synonyms
    B230104P22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925226
    NCBI Gene: 77976
  • Gene Overview
    MyGene.info: NUAK1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr10:84370905-84440597 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      69693 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 41.42 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NUAK1, NUAK family kinase 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NUAK1, NUAK family kinase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARK5
  • Links
    NCBI Gene ID: 9891
    neXtProt AC: NX_O60285
    UniProt: O60285

  • Chr Location
    12q23.3; chr12:106063347-106140033 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 8896
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NUAK1
  • Gene Tree
    Nuak1
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted disruption of this gene die perinatally displaying omphalocele with a failure in closure of the secondary body wall. No gross morphological defects are detected in brain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    24
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    241
  • Tissues
    93
  • cDNA Data
    38
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022766 VEGA Gene Model | MGI Sequence Detail 69693 C57BL/6J ±  kb
    transcript OTTMUST00000054650 VEGA | MGI Sequence Detail 5558 Not Applicable  
    polypeptide OTTMUSP00000026103 VEGA | MGI Sequence Detail 658 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      239 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 38
      Primer pair 2

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2143718, MGI:2143843
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 7
      Gene Ontology 4
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:253240 Lasagna-Reeves CA, et al., Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model. Neuron. 2016 Oct 19;92(2):407-418
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/11/2018
    MGI 6.12     		The Jackson Laboratory