Nuak1
Gene Detail

Symbol

Name
ID

Nuak1
NUAK family, SNF1-like kinase, 1
MGI:1925226

Synonyms

B230104P22Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 10
41.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:84370905-84440597 bp, - strand From VEGA annotation of GRCm38   69693 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:8896  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Nuak1

Human
homologs

Human Homolog		NUAK1, NUAK family, SNF1-like kinase, 1
NCBI Gene ID		9891
neXtProt AC		NX_O60285
Human Synonyms		ARK5
Human Chr (Location)		12q23.3; chr12:106063347-106140033 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(14) : Gene trapped(10) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a targeted disruption of this gene die perinatally displaying omphalocele with a failure in closure of the secondary body wall. No gross morphological defects are detected in brain.

 

Interactions

Nuak1 interacts with 341 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (20 annotations)

Process	cell adhesion, cellular response to DNA damage stimulus, ...
Component	cytoplasm, microtubule cytoskeleton, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)

Data Summary: Results (241)    Tissues (93)    Images (50)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	145
In situ reporter (knock in)	90
RT-PCR	6

cDNA source data(37)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(39) cDNA(37) Primer pair(2)
Microarray probesets(1)

Other database
links

VEGA Gene Model	OTTMUSG00000022766 (Evidence)
Ensembl Gene Model	ENSMUSG00000020032 (Evidence)
Entrez Gene	77976 (Evidence)
UniGene	25874
DFCI	TC1718234, TC1629605
DoTS	DT.103561381
NIA Mouse Gene Index	U032073
EC	2.7.11.1
Consensus CDS Project	CCDS24079.1
International Mouse Knockout Project Status	Nuak1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022766	VEGA Gene Model | MGI Sequence Detail	69693	C57BL/6J
transcript	OTTMUST00000054650	VEGA | MGI Sequence Detail	5558	Not Applicable
polypeptide	OTTMUSP00000026103	VEGA | MGI Sequence Detail	658	Not Applicable

All sequences(27) RefSeq(2) UniProt(3)

Polymorphisms

SNPs within 2kb(239 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000011473	NUAK family SNF1-like kinase 1

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:200007 Courchet J, et al., Terminal axon branching is regulated by the LKB1-NUAK1 kinase pathway via presynaptic mitochondrial capture. Cell. 2013 Jun 20;153(7):1510-25
All references(37)

Other
accession IDs

MGI:2143718, MGI:2143843