About   Help   FAQ
Nuak1
Gene Detail
 Symbol
Name
ID
Nuak1
NUAK family, SNF1-like kinase, 1
MGI:1925226
Synonyms B230104P22Rik
Feature Type protein coding gene
Genetic Map
Chromosome 10
41.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:84370905-84440597 bp, - strand
From VEGA annotation of GRCm38

  69693 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8896  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Nuak1

Human
homologs
Human Homolog NUAK1, NUAK family, SNF1-like kinase, 1
NCBI Gene ID 9891
neXtProt AC  NX_O60285
Human Synonyms  ARK5
Human Chr (Location)  12q23.3; chr12:106063347-106140033 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(10) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted disruption of this gene die perinatally displaying omphalocele with a failure in closure of the secondary body wall. No gross morphological defects are detected in brain.
 
Interactions
Nuak1 interacts with 341 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell adhesion, cellular response to DNA damage stimulus, ...
Component cytoplasm, microtubule cytoskeleton, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (241)    Tissues (93)    Images (50)
Theiler Stages: 11, 13, 15, 20, 22, 23, 26, 28
Assay TypeResults
RNA in situ 145
In situ reporter (knock in) 90
RT-PCR 6
cDNA source data(37)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) cDNA(37) Primer pair(2)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000022766 (Evidence)
Ensembl Gene ModelENSMUSG00000020032 (Evidence)
Entrez Gene77976 (Evidence)
UniGene25874
DFCITC1629605, TC1718234
DoTSDT.103561381
NIA Mouse Gene IndexU032073
EC2.7.11.1
Consensus CDS ProjectCCDS24079.1
International Mouse Knockout Project StatusNuak1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022766 VEGA Gene Model | MGI Sequence Detail 69693 C57BL/6J ±  kb
transcript OTTMUST00000054650 VEGA | MGI Sequence Detail 5558 Not Applicable 
polypeptide OTTMUSP00000026103 VEGA | MGI Sequence Detail 658 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(239 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000011473 NUAK family SNF1-like kinase 1
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:200007 Courchet J, et al., Terminal axon branching is regulated by the LKB1-NUAK1 kinase pathway via presynaptic mitochondrial capture. Cell. 2013 Jun 20;153(7):1510-25
All references(36)
Other
accession IDs
MGI:2143718, MGI:2143843

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/16/2014
MGI 5.19
The Jackson Laboratory