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Nuak1 Gene Detail
Summary
  • Symbol
    Nuak1
  • Name
    NUAK family, SNF1-like kinase, 1
  • Synonyms
    B230104P22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925226
    NCBI Gene: 77976
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:84206769-84276461 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 41.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1850 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925226
 protein coding gene Chr10:84206764-84282028 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017590
 protein coding gene Chr10:85229574-85303676 (-)
A/J MGP_AJ_G0017570
 protein coding gene Chr10:82341147-82412148 (-)
AKR/J MGP_AKRJ_G0017529
 protein coding gene Chr10:84625481-84696507 (-)
BALB/cJ MGP_BALBcJ_G0017533
 protein coding gene Chr10:82588457-82660428 (-)
C3H/HeJ MGP_C3HHeJ_G0017355
 protein coding gene Chr10:84712334-84782963 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017990
 protein coding gene Chr10:88127165-88199158 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015674
 protein coding gene Chr10:78170429-78241082 (-)
CAST/EiJ MGP_CASTEiJ_G0016922
 protein coding gene Chr10:84570862-84637356 (-)
CBA/J MGP_CBAJ_G0017325
 protein coding gene Chr10:91820099-91897067 (-)
DBA/2J MGP_DBA2J_G0017431
 protein coding gene Chr10:81484611-81555302 (-)
FVB/NJ MGP_FVBNJ_G0017425
 protein coding gene Chr10:80720758-80790141 (-)
LP/J MGP_LPJ_G0017503
 protein coding gene Chr10:85872200-85947477 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017453
 protein coding gene Chr10:93425406-93498913 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018027
 protein coding gene Chr10:84543525-84625501 (-)
PWK/PhJ MGP_PWKPhJ_G0016703
 protein coding gene Chr10:81342261-81411761 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016492
 protein coding gene Chr10:83166847-83241860 (-)
WSB/EiJ MGP_WSBEiJ_G0016981
 protein coding gene Chr10:84541593-84615966 (-)



Homology
more
  • Human Ortholog
    NUAK1, NUAK family kinase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUAK1, NUAK family kinase 1
  • Synonyms
    ARK5
  • Links
    NCBI Gene ID: 9891
    UniProt: O60285

  • Chr Location
    12q23.3; chr12:106063345-106138954 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NUAK1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted disruption of this gene die perinatally displaying omphalocele with a failure in closure of the secondary body wall. No gross morphological defects are detected in brain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    994
  • Tissues
    101
  • cDNA Data
    38
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020032 Ensembl Gene Model | MGI Sequence Detail 69693 C57BL/6J ±  kb
    transcript ENSMUST00000020220 Ensembl | MGI Sequence Detail 5558 Not Applicable  
    polypeptide ENSMUSP00000020220 Ensembl | MGI Sequence Detail 658 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 38
      Primer pair 3

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2143718, MGI:2143843
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 11
      Gene Ontology 10
      Phenotypes 20
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:366591 Cao L, et al., NUAK1 activates STAT5/GLI1/SOX2 signaling to enhance cancer cell expansion and drives chemoresistance in gastric cancer. Cell Rep. 2024 Jul 23;43(7):114446
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/18/2025
    MGI 6.24     		The Jackson Laboratory