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Rdh12 Gene Detail
Summary
  • Symbol
    Rdh12
  • Name
    retinol dehydrogenase 12
  • Synonyms
    A930033N07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925224
    NCBI Gene: 77974
  • Gene Overview
    MyGene.info: RDH12
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:79208914-79222665 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13752 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 35.51 cM, cytoband D2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RDH12, retinol dehydrogenase 12
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RDH12, retinol dehydrogenase 12
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LCA13, RP53, SDR7C2
  • Links
    NCBI Gene ID: 145226
    neXtProt AC: NX_Q96NR8
    UniProt: Q96NR8

  • Chr Location
    14q24.1; chr14:67701886-67734451 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human RDH12 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Deletion of this gene in mice results in slowed kinetics of all-trans-retinal reduction leading to delayed dark adaptation and increased susceptibility to light-induced photoreceptor apoptosis from accelerated 11-cis-retinal production.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000027652 VEGA Gene Model | MGI Sequence Detail 13752 C57BL/6J ±  kb
    transcript OTTMUST00000068427 VEGA | MGI Sequence Detail 1678 Not Applicable  
    polypeptide OTTMUSP00000034596 VEGA | MGI Sequence Detail 316 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      83 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 38

      Microarray probesets 4
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 6
      Gene Ontology 3
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:190746 Osuala K, et al., Physiological and genomic consequences of adrenergic deficiency during embryonic/fetal development in mice: impact on retinoic acid metabolism. Physiol Genomics. 2012 Oct 2;44(19):934-47

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory