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Rdh12 Gene Detail
Summary
  • Symbol
    Rdh12
  • Name
    retinol dehydrogenase 12
  • Synonyms
    A930033N07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925224
    NCBI Gene: 77974
  • Gene Overview
    MyGene.info: RDH12
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:79208913-79222664 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 35.51 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    83 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925224
protein coding gene Chr12:79208913-79222665 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019882
protein coding gene Chr12:79491466-79506157 (+)
A/J MGP_AJ_G0019840
protein coding gene Chr12:76636196-76649874 (+)
AKR/J MGP_AKRJ_G0019815
protein coding gene Chr12:78707999-78723225 (+)
BALB/cJ MGP_BALBcJ_G0019819
protein coding gene Chr12:76887559-76902553 (+)
C3H/HeJ MGP_C3HHeJ_G0019625
protein coding gene Chr12:79186237-79199972 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020271
protein coding gene Chr12:81841584-81855334 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017890
protein coding gene Chr12:73653554-73667148 (+)
CAST/EiJ MGP_CASTEiJ_G0019175
protein coding gene Chr12:74022202-74036853 (+)
CBA/J MGP_CBAJ_G0019596
protein coding gene Chr12:85032023-85045750 (+)
DBA/2J MGP_DBA2J_G0019711
protein coding gene Chr12:76256612-76270467 (+)
FVB/NJ MGP_FVBNJ_G0019697
protein coding gene Chr12:75070219-75084310 (+)
LP/J MGP_LPJ_G0019783
protein coding gene Chr12:79426091-79440158 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019736
protein coding gene Chr12:88074493-88088066 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020306
protein coding gene Chr12:78227800-78243392 (+)
PWK/PhJ MGP_PWKPhJ_G0018941
protein coding gene Chr12:70621640-70636405 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018735
protein coding gene Chr12:72728042-72741621 (+)
WSB/EiJ MGP_WSBEiJ_G0019228
protein coding gene Chr12:78847147-78862624 (+)



Homology
more
  • Human Ortholog
    RDH12, retinol dehydrogenase 12
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RDH12, retinol dehydrogenase 12
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LCA13, RP53, SDR7C2
  • Links
    NCBI Gene ID: 145226
    neXtProt AC: NX_Q96NR8
    UniProt: Q96NR8

  • Chr Location
    14q24.1; chr14:67701886-67734451 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human RDH12 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Deletion of this gene in mice results in slowed kinetics of all-trans-retinal reduction leading to delayed dark adaptation and increased susceptibility to light-induced photoreceptor apoptosis from accelerated 11-cis-retinal production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 77974 NCBI Gene Model | MGI Sequence Detail 13752 C57BL/6J ±  kb
    transcript NM_030017 RefSeq | MGI Sequence Detail 1694 C57BL/6  
    polypeptide Q8BYK4 UniProt | EBI | MGI Sequence Detail 316 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 38

      Microarray probesets 4
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 6
      Gene Ontology 2
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:190746 Osuala K, et al., Physiological and genomic consequences of adrenergic deficiency during embryonic/fetal development in mice: impact on retinoic acid metabolism. Physiol Genomics. 2012 Oct 2;44(19):934-47

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory