Rdh12
Gene Detail

Symbol Name ID

Rdh12 retinol dehydrogenase 12 MGI:1925224

Synonyms

A930033N07Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 12

35.51 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr12:79208914-79222665 bp, + strand From VEGA annotation of GRCm38   13752 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:110830  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rdh12

Human homologs

Human Homolog		RDH12, retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
NCBI Gene ID		145226
neXtProt AC		NX_Q96NR8
Human Synonyms		LCA13, LCA3, RP53, SDR7C2
Human Chr (Location)		14q24.1; chr14:68168603-68201168 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human RDH12

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Deletion of this gene in mice results in slowed kinetics of all-trans-retinal reduction leading to delayed dark adaptation and increased susceptibility to light-induced photoreceptor apoptosis from accelerated 11-cis-retinal production.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	metabolic process, response to stimulus, ...
Component	intracellular
Function	oxidoreductase activity, retinol dehydrogenase activity

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (100)    Tissues (97)    Images (5)
Theiler Stages: 22, 28

Assay Type	Results
RNA in situ	100

cDNA source data(35)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(37) cDNA(37)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000027652 (Evidence)
Ensembl Gene Model	ENSMUSG00000021123 (Evidence)
Entrez Gene	77974 (Evidence)
UniGene	274373
DFCI	TC1580388, TC1595774, TC1602247
DoTS	DT.110933804, DT.486176, DT.91359678, DT.94293512
NIA Mouse Gene Index	U014141
EC	1.1.1.-
Consensus CDS Project	CCDS26009.1
International Mouse Knockout Project Status	Rdh12

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027652	VEGA Gene Model | MGI Sequence Detail	13752	C57BL/6J
transcript	OTTMUST00000068427	VEGA | MGI Sequence Detail	1678	Not Applicable
polypeptide	OTTMUSP00000034596	VEGA | MGI Sequence Detail	316	Not Applicable

All sequences(36) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(76 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002347	Glucose/ribitol dehydrogenase
InterPro	IPR016040	NAD(P)-binding domain
InterPro	IPR002198	Short-chain dehydrogenase/reductase SDR
Protein Ontology	PR:000013850	retinol dehydrogenase 12

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:190746 Osuala K, et al., Physiological and genomic consequences of adrenergic deficiency during embryonic/fetal development in mice: impact on retinoic acid metabolism. Physiol Genomics. 2012 Oct 2;44(19):934-47
All references(41)