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Rdh12
Gene Detail
Symbol

Name
ID
Rdh12
retinol dehydrogenase 12
MGI:1925224
Synonyms
A930033N07Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 12
35.51 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:79208914-79222665 bp, + strand
From VEGA annotation of GRCm38

  13752 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:110830  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: RDH12
Gene Tree: Rdh12

Human
homologs
RDH12, retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 145226
neXtProt AC: NX_Q96NR8

Human Synonyms: LCA13, LCA3, RP53, SDR7C2

Human Chr (Location): 14q24.1; chr14:67701886-67734451 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human RDH12

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Deletion of this gene in mice results in slowed kinetics of all-trans-retinal reduction leading to delayed dark adaptation and increased susceptibility to light-induced photoreceptor apoptosis from accelerated 11-cis-retinal production.
 
Interactions
Rdh12 interacts with 119 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process metabolic process, oxidation-reduction process, ...
Component intracellular
Function 2-hydroxytetrahydrofuran dehydrogenase activity, 3-hydroxymenthone dehydrogenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (100)    Tissues (97)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 100
cDNA source data(35)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) cDNA(37)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000027652 (Evidence)
Ensembl Gene Model ENSMUSG00000021123 (Evidence)
Entrez Gene 77974 (Evidence)
UniGene 274373
DFCI TC1580388, TC1602247, TC1595774
DoTS DT.91359678, DT.486176, DT.110933804, DT.94293512
NIA Mouse Gene Index U014141
EC 1.1.1.-
Consensus CDS Project CCDS26009.1
International Mouse Phenotyping Consortium Status Rdh12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027652 VEGA Gene Model | MGI Sequence Detail 13752 C57BL/6J ±  kb
transcript OTTMUST00000068427 VEGA | MGI Sequence Detail 1678 Not Applicable 
polypeptide OTTMUSP00000034596 VEGA | MGI Sequence Detail 316 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(83 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000013850 retinol dehydrogenase 12
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:190746 Osuala K, et al., Physiological and genomic consequences of adrenergic deficiency during embryonic/fetal development in mice: impact on retinoic acid metabolism. Physiol Genomics. 2012 Oct 2;44(19):934-47
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory