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Hook1
Gene Detail
Symbol

Name
ID
Hook1
hook homolog 1 (Drosophila)
MGI:1925213
Synonyms
A930033L17Rik, abnormal spermatozoon head shape, azh
Feature Type
protein coding gene
Genetic Map
Chromosome 4
44.17 cM, cytoband C5
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:95967240-96025413 bp, + strand
From VEGA annotation of GRCm38

  58174 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9289  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hook1

Human
homologs
Human Homolog HOOK1, hook microtubule-tethering protein 1
NCBI Gene ID 51361
neXtProt AC  NX_Q9UJC3
Human Synonyms  HK1
Human Chr (Location)  1p32.1; chr1:59814786-59876378 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(4) Radiation induced(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice have abnormal ladle shaped sperm with up to 40% lacking a flagella. Nonetheless, most males breed, although litter size is reduced.
 
Interactions
Hook1 interacts with 359 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cell differentiation, early endosome to late endosome transport, ...
Component cytoplasm, cytoskeleton, ...
Function actin binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(12)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000008119 (Evidence)
Ensembl Gene ModelENSMUSG00000028572 (Evidence)
Entrez Gene77963 (Evidence)
DFCITC1578586, TC1587819, TC1597314
DoTSDT.101736029, DT.55282477, DT.91334169
NIA Mouse Gene IndexU004513
PDB1WIX
Consensus CDS ProjectCCDS18367.1
International Mouse Knockout Project StatusHook1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008119 VEGA Gene Model | MGI Sequence Detail 58174 C57BL/6J ±  kb
transcript OTTMUST00000018458 VEGA | MGI Sequence Detail 5517 Not Applicable 
polypeptide OTTMUSP00000008480 VEGA | MGI Sequence Detail 728 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(11) UniProt(2)
Polymorphisms
SNPs within 2kb(287 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008636 HOOK/CCDC88
Protein Ontology PR:000008682 protein Hook homolog 1
References
(Earliest) J:13990 Hugenholtz AP, Abnormal spermatazoon head shape. Mouse News Lett. 1984;71:35
(Latest) J:196086 Appler JM, et al., Gata3 is a critical regulator of cochlear wiring. J Neurosci. 2013 Feb 20;33(8):3679-91
All references(40)
Other
accession IDs
MGD-MRK-1490, MGI:88126

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory