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Prickle2
Gene Detail
Symbol

Name
ID
Prickle2
prickle homolog 2 (Drosophila)
MGI:1925144
Synonyms
6230400G14Rik, 6720451F06Rik, mpk2
Feature Type
protein coding gene
Genetic Map
Chromosome 6
41.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:92370908-92567366 bp, - strand
From VEGA annotation of GRCm38

  196459 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17889  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRICKLE2
Gene Tree: Prickle2

Human
homologs
PRICKLE2, prickle homolog 2 (Drosophila)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 166336
neXtProt AC: NX_Q7Z3G6

Human Synonyms: EPM5

Human Chr (Location): 3p14.1; chr3:64093850-64445476 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PRICKLE2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Spontaneous(1) Targeted(3)
Genomic Mutations involving Prickle2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit increased susceptibility to electroconvulsive or PTZ-induced seizures. Mice heterozygous for a knock-out allele exhibit increased susceptibility to electroconvulsive seizures.
 
Interactions
Prickle2 interacts with 491 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (14 records)
Data Summary: Results (153)    Tissues (137)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 153
cDNA source data(47)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PRICKLE2 ; Xenbase prickle2 ; ZFIN prickle2b    NEW 
Molecular
reagents
All nucleic(49) cDNA(48) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000022502 (Evidence)
Ensembl Gene Model ENSMUSG00000030020 (Evidence)
Entrez Gene 243548 (Evidence)
UniGene 248820
DFCI TC1601829, TC1635674, TC1613499, TC1662113
DoTS DT.87030720, DT.55245716, DT.525643, DT.102541052, DT.40157176
NIA Mouse Gene Index U316276, U027646
Consensus CDS Project CCDS39572.1, CCDS51854.1
International Mouse Phenotyping Consortium Status Prickle2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022502 VEGA Gene Model | MGI Sequence Detail 196459 C57BL/6J ±  kb
transcript OTTMUST00000053868 VEGA | MGI Sequence Detail 7679 Not Applicable 
polypeptide OTTMUSP00000025638 VEGA | MGI Sequence Detail 845 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(12) UniProt(2)
Polymorphisms
SNPs within 2kb(2607 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010442 PET domain
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000013212 prickle-like protein 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:214983 Mei X, et al., Functional characterization of Prickle2 and BBS7 identify overlapping phenotypes yet distinct mechanisms. Dev Biol. 2014 Aug 15;392(2):245-55
All references(47)
Other
accession IDs
MGI:1923374

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory