Prickle2
Gene Detail

Symbol Name ID

Prickle2 prickle homolog 2 (Drosophila) MGI:1925144

Synonyms

6230400G14Rik, 6720451F06Rik, mpk2

Feature Type

protein coding gene

Genetic Map

Chromosome 6

41.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr6:92370908-92567366 bp, - strand From VEGA annotation of GRCm38   196459 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:17889  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Prickle2

Human homologs

Human Homolog		PRICKLE2, prickle homolog 2 (Drosophila)
NCBI Gene ID		166336
neXtProt AC		NX_Q7Z3G6
Human Synonyms		EPM5
Human Chr (Location)		3p14.1; chr3:64079526-64211131 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PRICKLE2

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Mice homozygous for a knock-out allele exhibit increased susceptibility to electroconvulsive or PTZ-induced seizures. Mice heterozygous for a knock-out allele exhibit increased susceptibility to electroconvulsive seizures.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	establishment or maintenance of epithelial cell apical/basal polarity, neuron projection development
Component	apicolateral plasma membrane, cytoplasm, ...
Function	metal ion binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (153)    Tissues (134)    Images (14)
Theiler Stages: 11, 12, 17, 20, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	153

cDNA source data(46)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(48) cDNA(47) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000022502 (Evidence)
Ensembl Gene Model	ENSMUSG00000030020 (Evidence)
Entrez Gene	243548 (Evidence)
UniGene	248820
DFCI	TC1601829, TC1613499, TC1635674, TC1662113
DoTS	DT.102541052, DT.40157176, DT.525643, DT.55245716, DT.87030720
NIA Mouse Gene Index	U027646
Consensus CDS Project	CCDS39572.1, CCDS51854.1
International Mouse Knockout Project Status	Prickle2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022502	VEGA Gene Model | MGI Sequence Detail	196459	C57BL/6J
transcript	OTTMUST00000053868	VEGA | MGI Sequence Detail	7679	Not Applicable
polypeptide	OTTMUSP00000025638	VEGA | MGI Sequence Detail	845	Not Applicable

All sequences(50) RefSeq(8) UniProt(2)

Polymorphisms

SNPs(1930 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR010442	PET domain
InterPro	IPR001781	Zinc finger, LIM-type
Protein Ontology	PR:000013212	prickle-like protein 2

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:185311 Yin H, et al., Comparison of phenotypes between different vangl2 mutants demonstrates dominant effects of the Looptail mutation during hair cell development. PLoS One. 2012;7(2):e31988
All references(45)

Other accession IDs

MGI:1923374