Lbh MGI Mouse Gene Detail - MGI:1925139

Symbol

Lbh
Name

limb-bud and heart
Synonyms

1810009F10Rik, 6720416L16Rik

Feature Type

protein coding gene
IDs

MGI:1925139
NCBI Gene: 77889
Gene Overview

MyGene.info: LBH
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:72918305-72941946 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 44.73 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

140 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925139	protein coding gene	Chr17:72918305-72941947 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024017	protein coding gene	Chr17:75455978-75480595 (+)
A/J	MGP_AJ_G0023975	protein coding gene	Chr17:73159365-73183941 (+)
AKR/J	MGP_AKRJ_G0023944	protein coding gene	Chr17:74189851-74214353 (+)
BALB/cJ	MGP_BALBcJ_G0023976	protein coding gene	Chr17:73074856-73098745 (+)
C3H/HeJ	MGP_C3HHeJ_G0023740	protein coding gene	Chr17:75112730-75138869 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024422	protein coding gene	Chr17:78184912-78214106 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021866	protein coding gene	Chr17:68867101-68890616 (+)
CAST/EiJ	MGP_CASTEiJ_G0023221	protein coding gene	Chr17:75561695-75587638 (+)
CBA/J	MGP_CBAJ_G0023715	protein coding gene	Chr17:81397962-81430132 (+)
DBA/2J	MGP_DBA2J_G0023844	protein coding gene	Chr17:71789215-71815711 (+)
FVB/NJ	MGP_FVBNJ_G0023810	protein coding gene	Chr17:71259264-71283503 (+)
LP/J	MGP_LPJ_G0023926	protein coding gene	Chr17:76197182-76220807 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023838	protein coding gene	Chr17:81270513-81297982 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024466	protein coding gene	Chr17:74687769-74711824 (+)
PWK/PhJ	MGP_PWKPhJ_G0022967	protein coding gene	Chr17:71122772-71148302 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022778	protein coding gene	Chr17:71358067-71381704 (+)
WSB/EiJ	MGP_WSBEiJ_G0023288	protein coding gene	Chr17:75525816-75558940 (+)

Human Ortholog

LBH, LBH regulator of WNT signaling pathway

Vertebrate Orthologs

10

Human Ortholog

LBH, LBH regulator of WNT signaling pathway
Orthology source: HomoloGene, HGNC
Links

HGNC:29532

NCBI Gene ID: 81606

neXtProt AC: NX_Q53QV2

UniProt: Q53QV2
Chr Location

2p23.1; chr2:30231531-30260033 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 12687
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: LBH
Protein SuperFamily

uncharacterized conserved protein
Gene Tree

Lbh

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
1 images
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired mammary gland development and decreased litter size.

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All GO Annotations

20
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

731
Tissues

76
cDNA Data

62
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA LBH

Xenbase lbh

ZFIN lbh

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Lbh interacts with 274 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

35
RefSeq

2
UniProt

2
CCDS

CCDS28964.1
UniGene

154109

Ensembl

ENSMUSG00000024063 (Evidence)
NCBI Gene

77889

			Length	Strain/Species	Flank
genomic	77889	NCBI Gene Model \| MGI Sequence Detail	23642	C57BL/6J	± kb
transcript	NM_029999	RefSeq \| MGI Sequence Detail	3068	C57BL/6
polypeptide	Q9CX60	UniProt \| EBI \| MGI Sequence Detail	105	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009691 protein LBH

(term hierarchy)
InterPro Domains

IPR038990 LBH domain

IPR042945 LBH domain containing protein

IPR013294 Protein LBH

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All nucleic 64

cDNA 63

Other 1

Microarray probesets 5

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MGI:1923995

Summaries

All 39

Developmental Gene Expression 10

Gene Ontology 6

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:290273 Ashad-Bishop K, et al., Loss of Limb-Bud-and-Heart (LBH) attenuates mammary hyperplasia and tumor development in MMTV-Wnt1 transgenic mice. Biochem Biophys Res Commun. 2019 Jan 8;508(2):536-542

TSS for Lbh:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr145786	Chr17:72918298-72918316 (+)	2 bp
Tssr145787	Chr17:72918495-72918547 (+)	216 bp
Tssr145788	Chr17:72921156-72921171 (+)	2,859 bp
Tssr145791	Chr17:72939621-72939635 (+)	21,323 bp
Tssr145792	Chr17:72939720-72939740 (+)	21,425 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/23/2021 MGI 6.16