Lbh MGI Mouse Gene Detail - MGI:1925139

Lbh Gene Detail

Symbol

Lbh
Name

limb-bud and heart
Synonyms

1810009F10Rik, 6720416L16Rik

Feature Type

protein coding gene
IDs

MGI:1925139
NCBI Gene: 77889
Gene Overview

MyGene.info: LBH

Sequence Map

Chr17:72918305-72941942 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

23638 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 44.73 cM, cytoband E2
Mapping Data

2 experiments

Human Ortholog

LBH, limb bud and heart development

Vertebrate Orthologs

10

Human Ortholog

LBH, limb bud and heart development
Orthology source: HomoloGene, HGNC
Links

HGNC:29532

NCBI Gene ID: 81606

neXtProt AC: NX_Q53QV2

UniProt: Q53QV2
Chr Location

2p23.1; chr2:30231531-30260033 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 12687
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: LBH
Protein SuperFamily

uncharacterized conserved protein
Gene Tree

Lbh

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
1 images
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

6 strains or lines available

Mice homozygous for a knock-out allele exhibit impaired mammary gland development and decreased litter size.

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All GO Annotations

17
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

92
Tissues

71
cDNA Data

61
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA LBH

ZFIN lbh

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Lbh interacts with 274 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

22
RefSeq

2
UniProt

2
CCDS

CCDS28964.1
UniGene

154109

			Length	Strain/Species	Flank
genomic	OTTMUSG00000028495	VEGA Gene Model \| MGI Sequence Detail	23638	C57BL/6J	± kb
transcript	OTTMUST00000070622	VEGA \| MGI Sequence Detail	3064	Not Applicable
polypeptide	OTTMUSP00000036017	VEGA \| MGI Sequence Detail	105	Not Applicable

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SNPs within 2kb

140 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000009691 protein LBH

(term hierarchy)
InterPro Domains

IPR013294 Protein LBH

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All nucleic 63

cDNA 62

Other 1

Microarray probesets 5

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MGI:1923995

Summaries

All 33

Developmental Gene Expression 8

Gene Ontology 5

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:220326 Lindley LE, et al., The WNT-controlled transcriptional regulator LBH is required for mammary stem cell expansion and maintenance of the basal lineage. Development. 2015 Mar 1;142(5):893-904

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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