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Tchp Gene Detail
Summary
  • Symbol
    Tchp
  • Name
    trichoplein, keratin filament binding
  • Synonyms
    A930031F18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925082
    NCBI Gene: 77832
  • Gene Overview
    MyGene.info: TCHP
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:114707765-114722327 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 55.99 cM, cytoband F
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    70 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925082
protein coding gene Chr5:114707760-114722327 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029943
protein coding gene Chr5:117479020-117493598 (+)
A/J MGP_AJ_G0029908
protein coding gene Chr5:112850596-112865137 (+)
AKR/J MGP_AKRJ_G0029846
protein coding gene Chr5:116429861-116444439 (+)
BALB/cJ MGP_BALBcJ_G0029919
protein coding gene Chr5:114214244-114228822 (+)
C3H/HeJ MGP_C3HHeJ_G0029639
protein coding gene Chr5:116940790-116955368 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030373
protein coding gene Chr5:122008763-122023308 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027601
protein coding gene Chr5:107670613-107684127 (+)
CAST/EiJ MGP_CASTEiJ_G0029047
protein coding gene Chr5:115873666-115888200 (+)
CBA/J MGP_CBAJ_G0029606
protein coding gene Chr5:126667710-126682281 (+)
DBA/2J MGP_DBA2J_G0029756
protein coding gene Chr5:112915847-112930407 (+)
FVB/NJ MGP_FVBNJ_G0029713
protein coding gene Chr5:111728529-111744277 (+)
LP/J MGP_LPJ_G0029845
protein coding gene Chr5:118047142-118061720 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029744
protein coding gene Chr5:131054800-131069366 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030414
protein coding gene Chr5:115903194-115917881 (+)
PWK/PhJ MGP_PWKPhJ_G0028761
protein coding gene Chr5:111573708-111589001 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028599
protein coding gene Chr5:113452205-113468419 (+)
WSB/EiJ MGP_WSBEiJ_G0029123
protein coding gene Chr5:116492753-116507256 (+)



Homology
more
  • Human Ortholog
    TCHP, trichoplein keratin filament binding
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TCHP, trichoplein keratin filament binding
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TpMs
  • Links
    NCBI Gene ID: 84260
    neXtProt AC: NX_Q9BT92
    UniProt: Q9BT92

  • Chr Location
    12q24.11; chr12:109880667-109918069 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 12686
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TCHP
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 77832 NCBI Gene Model | MGI Sequence Detail 14563 C57BL/6J ±  kb
    transcript NM_029992 RefSeq | MGI Sequence Detail 2886 C57BL/6  
    polypeptide Q3TVW5 UniProt | EBI | MGI Sequence Detail 497 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000016191 trichoplein keratin filament-binding protein
    • InterPro Domains
      IPR001289 Nuclear transcription factor Y subunit A
      IPR026773 Trichoplein keratin filament-binding protein
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 31
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2141121
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:236569 Inaba H, et al., Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway. J Cell Biol. 2016 Feb 15;212(4):409-23

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory