Fbxo42 MGI Mouse Gene Detail - MGI:1924992

Symbol

Fbxo42
Name

F-box protein 42
Synonyms

6720460I06Rik

Feature Type

protein coding gene
IDs

MGI:1924992
NCBI Gene: 213499
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:140875224-140931373 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 73.41 cM
Mapping Data

2 experiments

SNPs within 2kb

1575 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924992	protein coding gene	Chr4:140875216-140931373 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029040	protein coding gene	Chr4:144164714-144235464 (+)
A/J	MGP_AJ_G0028999	protein coding gene	Chr4:137913051-137971454 (+)
AKR/J	MGP_AKRJ_G0028951	protein coding gene	Chr4:141890382-141948012 (+)
BALB/cJ	MGP_BALBcJ_G0029023	protein coding gene	Chr4:138601007-138664538 (+)
C3H/HeJ	MGP_C3HHeJ_G0028737	protein coding gene	Chr4:142266825-142325591 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029464	protein coding gene	Chr4:149217612-149278095 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026735	protein coding gene	Chr4:130826876-130883847 (+)
CAST/EiJ	MGP_CASTEiJ_G0028169	protein coding gene	Chr4:140523139-140581945 (+)
CBA/J	MGP_CBAJ_G0028701	protein coding gene	Chr4:153520550-153584997 (+)
DBA/2J	MGP_DBA2J_G0028851	protein coding gene	Chr4:138304206-138364732 (+)
FVB/NJ	MGP_FVBNJ_G0028818	protein coding gene	Chr4:137409623-137470188 (+)
LP/J	MGP_LPJ_G0028950	protein coding gene	Chr4:144186290-144246407 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028844	protein coding gene	Chr4:157365244-157426082 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029502	protein coding gene	Chr4:142418511-142476596 (+)
PWK/PhJ	MGP_PWKPhJ_G0027890	protein coding gene	Chr4:135192683-135250983 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027715	protein coding gene	Chr4:138234035-138296030 (+)
WSB/EiJ	MGP_WSBEiJ_G0028247	protein coding gene	Chr4:142698755-142757842 (+)

Human Ortholog

FBXO42, F-box protein 42

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBXO42, F-box protein 42
Synonyms

Fbx42, JFK
Links

HGNC:29249

NCBI Gene ID: 54455

UniProt: Q6P3S6
Chr Location

1p36.13; chr1:16246840-16352487 (-) GRCh38

MGI Vertebrate Homology

Fbxo42 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FBXO42
Gene Tree

Fbxo42

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

235
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

227
Targeted

2
Genomic Mutations

3 involving Fbxo42
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

222 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

8
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

5
cDNA Data

105
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fbxo42

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All Sequences

55
RefSeq

6
UniProt

7
CCDS

CCDS18866.1

Ensembl

ENSMUSG00000028920 (Evidence)
NCBI Gene

213499

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028920	Ensembl Gene Model \| MGI Sequence Detail	56150	C57BL/6J	± kb
transcript	ENSMUST00000030757	Ensembl \| MGI Sequence Detail	5934	Not Applicable
polypeptide	ENSMUSP00000030757	Ensembl \| MGI Sequence Detail	717	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000007411 F-box only protein 42

(term hierarchy)
InterPro Domains

IPR001810 F-box domain

IPR036047 F-box-like domain superfamily

IPR052821 F-box only substrate-recognition component

IPR015915 Kelch-type beta propeller
GlyGen

Q6PDJ6 3 sites, 1 N-linked glycan (1 site)

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All nucleic 105

cDNA 105

Microarray probesets 3

Summaries

All 45

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 17
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fbxo42:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40030	Chr4:140875222-140875282 (+)	28 bp
Tssr40031	Chr4:140877787-140877794 (+)	2,567 bp
Tssr40032	Chr4:140878322-140878361 (+)	3,118 bp
Tssr40033	Chr4:140907513-140907518 (+)	32,292 bp
Tssr40034	Chr4:140920973-140920994 (+)	45,760 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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