Adamtsl1 Gene Detail

Summary

• Symbol
  Adamtsl1
• Name
  ADAMTS-like 1
• Synonyms
  5930437A14Rik, 6720426B09Rik, punctin-1

• Feature Type
  protein coding gene
• IDs
  MGI:1924989
  NCBI Gene: 77739
• Alliance
  gene page
• Transcription Start Sites
  4 TSS

Location &
Maps

• Sequence Map
  Chr4:85432409-86346622 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 4, 40.32 cM, cytoband C3
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  33622 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924989	protein coding gene	Chr4:85432242-86346627 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028409	protein coding gene	Chr4:85797809-86188395 (+)
A/J	MGP_AJ_G0028370	protein coding gene	Chr4:82774777-83153707 (+)
AKR/J	MGP_AKRJ_G0028319	protein coding gene	Chr4:84901204-85282983 (+)
BALB/cJ	MGP_BALBcJ_G0028390	protein coding gene	Chr4:82989628-83379136 (+)
C3H/HeJ	MGP_C3HHeJ_G0028105	protein coding gene	Chr4:85548930-85939457 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028829	protein coding gene	Chr4:89074712-89459229 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026129	protein coding gene	Chr4:78650933-79014672 (+)
CAST/EiJ	MGP_CASTEiJ_G0027546	protein coding gene	Chr4:83451666-83834255 (+)
CBA/J	MGP_CBAJ_G0028074	protein coding gene	Chr4:91821960-92236828 (+)
DBA/2J	MGP_DBA2J_G0028223	protein coding gene	Chr4:82558265-82934057 (+)
FVB/NJ	MGP_FVBNJ_G0028189	protein coding gene	Chr4:81547270-81924191 (+)
LP/J	MGP_LPJ_G0028323	protein coding gene	Chr4:86125541-86522729 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028218	protein coding gene	Chr4:96902459-97298131 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028866	protein coding gene	Chr4:84981551-85361368 (+)
PWK/PhJ	MGP_PWKPhJ_G0027269	protein coding gene	Chr4:80909390-81278040 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027094	protein coding gene	Chr4:82531574-82916270 (+)
WSB/EiJ	MGP_WSBEiJ_G0027622	protein coding gene	Chr4:85170034-85547608 (+)

Homology

• Human Ortholog
  ADAMTSL1, ADAMTS like 1

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  ADAMTSL1, ADAMTS like 1
  
• Synonyms
  ADAMTSL-1, ADAMTSR1, C9orf94, PUNCTIN
• Links
  HGNC:14632

  NCBI Gene ID: 92949

  UniProt: Q8N6G6

  
  
• Chr Location
  9p22.2-p22.1; chr9:17906563-18910950 (+)  GRCh38

---

• MGI Vertebrate Homology
  Adamtsl1 stringent orthology
  1 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: ADAMTSL1
• Gene Tree
  Adamtsl1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  9 phenotype references
  

• All Mutations and Alleles
  9
• Chemically induced (other)
  2
• Endonuclease-mediated
  2
• Gene trapped
  3
• Radiation induced
  1
• Targeted
  1
• Genomic Mutations
  3 involving Adamtsl1
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  99 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

Expression

• Assay Results
  707
• Tissues
  1
• cDNA Data
  23
• Literature Summary
  1

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase adamtsl1

Sequences &
Gene Models

• All Sequences
  89
• RefSeq
  20
• UniProt
  9
• CCDS
  CCDS18304.1, CCDS51217.1

• Ensembl
  ENSMUSG00000066113 (Evidence)
• NCBI Gene
  77739

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000066113	Ensembl Gene Model | MGI Sequence Detail	914214	C57BL/6J
transcript	ENSMUST00000107178	Ensembl | MGI Sequence Detail	7839	Not Applicable
polypeptide	ENSMUSP00000102796	Ensembl | MGI Sequence Detail	1753	Not Applicable

Protein
Information

• UniProt
  9 Sequences
• Protein Ontology
  PR:000003738 ADAMTS-like protein 1
  (term hierarchy)
• InterPro Domains
  IPR013273 ADAMTS/ADAMTS-like
  IPR045371 ADAMTS/ADAMTS-like, cysteine-rich domain 3
  IPR010294 ADAMTS/ADAMTS-like, Spacer 1
  IPR050439 ADAMTS and ADAMTS-like
  IPR050958 Cell Adhesion and Cytoskeletal Organization
  IPR013098 Immunoglobulin I-set
  IPR007110 Immunoglobulin-like domain
  IPR036179 Immunoglobulin-like domain superfamily
  IPR013783 Immunoglobulin-like fold
  IPR003599 Immunoglobulin subtype
  IPR003598 Immunoglobulin subtype 2
  IPR010909 PLAC
  IPR000884 Thrombospondin type-1 (TSP1) repeat
  IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
• GlyGen
  Q8BLI0 10 sites, 3 N-linked glycans (5 sites)

Molecular
Reagents

• All nucleic 24

  cDNA 23

  Primer pair 1

  
  

  Microarray probesets 8

Other
Accession IDs

MGI:2682933

References

• Summaries
  All 34

  Developmental Gene Expression 1

  Gene Ontology 1

  Phenotypes 9
• Earliest
  J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
• Latest
  J:165751 Du J, et al., O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol. 2010 Oct 1;346(1):25-38

TSS for Adamtsl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37723	Chr4:85971896-85971918 (+)	539,498 bp
Tssr37724	Chr4:85971924-85971958 (+)	539,532 bp
Tssr37725	Chr4:85972124-85972224 (+)	539,765 bp
Tssr37726	Chr4:85972231-85972249 (+)	539,831 bp