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Trat1 Gene Detail
Summary
  • Symbol
    Trat1
  • Name
    T cell receptor associated transmembrane adaptor 1
  • Synonyms
    C030046M14Rik, Tcrim, Trim
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924897
    NCBI Gene: 77647
  • Gene Overview
    MyGene.info: TRAT1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:48730774-48772021 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 30.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    756 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924897
protein coding gene Chr16:48731914-48810528 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022866
protein coding gene Chr16:47610033-47645285 (-)
A/J MGP_AJ_G0022831
protein coding gene Chr16:45513694-45550526 (-)
AKR/J MGP_AKRJ_G0022804
protein coding gene Chr16:47026055-47066830 (-)
BALB/cJ MGP_BALBcJ_G0022833
protein coding gene Chr16:45558265-45596499 (-)
C3H/HeJ MGP_C3HHeJ_G0022596
protein coding gene Chr16:47117971-47157582 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023280
protein coding gene Chr16:48785038-48830293 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020793
protein coding gene Chr16:45643509-45678968 (-)
CAST/EiJ MGP_CASTEiJ_G0022122
protein coding gene Chr16:47368266-47407291 (-)
CBA/J MGP_CBAJ_G0022569
protein coding gene Chr16:50715426-50749805 (-)
DBA/2J MGP_DBA2J_G0022700
protein coding gene Chr16:45223829-45266277 (-)
FVB/NJ MGP_FVBNJ_G0022676
protein coding gene Chr16:45121262-45158436 (-)
LP/J MGP_LPJ_G0022768
protein coding gene Chr16:47355791-47397487 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022694
protein coding gene Chr16:50389429-50430703 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023295
protein coding gene Chr16:47014784-47066321 (-)
PWK/PhJ MGP_PWKPhJ_G0021862
protein coding gene Chr16:45581891-45618194 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021692
protein coding gene Chr16:46905829-46948460 (-)
WSB/EiJ MGP_WSBEiJ_G0022167
protein coding gene Chr16:47068411-47111074 (-)



Homology
more
  • Human Ortholog
    TRAT1, T cell receptor associated transmembrane adaptor 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TRAT1, T cell receptor associated transmembrane adaptor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSPC062, pp29/30, TCRIM, TRIM
  • Links
    NCBI Gene ID: 50852
    neXtProt AC: NX_Q6PIZ9
    UniProt: Q6PIZ9

  • Chr Location
    3q13.13; chr3:108822698-108855005 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice with homozygous disruption of this gene display decreased body weight and a proportional reduction in lymph organ cell numbers; however T and B cell function are normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030775 Ensembl Gene Model | MGI Sequence Detail 41248 C57BL/6J ±  kb
transcript ENSMUST00000231701 Ensembl | MGI Sequence Detail 4665 Not Applicable  
polypeptide ENSMUSP00000155986 Ensembl | MGI Sequence Detail 197 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR020399 T-cell receptor-associated transmembrane adapter 1
Molecular
Reagents
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  • All nucleic 16
    cDNA 16

    Microarray probesets 3
References
more
  • Summaries
    All 23
    Gene Ontology 2
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory